PD-L1: Can it be a biomarker for the prognosis or a promising therapeutic target in cervical cancer?

2022 ◽  
Vol 103 ◽  
pp. 108484
Author(s):  
Ruizhe Wang ◽  
Yi Zhang ◽  
Fengping Shan
Keyword(s):  
Cervical Cancer ◽  
Therapeutic Target ◽  
Promising Therapeutic Target

Skeletal-Muscle Metabolic Reprogramming in ALS-SOD1 G93G Mice Predates Disease Onset and is a Promising Therapeutic Target

2019 ◽  
Author(s):  
Silvia Scaricamazza ◽  
Illari Salvatori ◽  
Giacomo Giacovazzo ◽  
Jean Philippe Loeffler ◽  
Frederique Renè ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Therapeutic Target ◽  
Disease Onset ◽  
Metabolic Reprogramming ◽  
Promising Therapeutic Target

LncRNA LINC00858 enhances cervical cancer cell growth through miR-3064-5p/ VMA21 axis

2021 ◽  
pp. 1-11
Author(s):  
Min Wei ◽  
Youguo Chen ◽  
Wensheng Du
Keyword(s):  
Cervical Cancer ◽  
Cell Proliferation ◽  
Cell Apoptosis ◽  
Luciferase Reporter ◽  
Cancer Cell Growth ◽  
Protein Coding ◽  
Gynecological Malignancy ◽  
Promising Therapeutic Target ◽  
Proliferation And Apoptosis ◽  
Reporter Assays

BACKGROUND: Cervical cancer (CC) is the most common form of gynecological malignancy. Long intergenic non-protein coding RNA 858 (LINC00858) has been identified to participate in multiple cancers. However, the role and mechanism of LINC00858 in CC cells are still elusive. AIM: The aim of this study is to explore the biological functions and mechanisms of LINC00858 in CC cells. METHODS: RT-qPCR analysis was used to examine the expression of LINC00858 in CC cells. EdU and colony formation assay were utilized to assess cell proliferation. TUNEL assay and flow cytometry assay were conducted to assess cell apoptosis. The mechanism regarding LINC00858 was certified through RNA pull down, RIP and luciferase reporter assays. RESULTS: The up-regulated LINC00858 was detected in CC cells. Reduction of LINC00858 effectively subdued CC cells proliferation and stimulated cell apoptosis. LINC00858 was determined to bind with miR-3064-5p and up-regulate VMA21 in CC cells. In rescue assays, miR-3064-5p down-regulation and VMA21 up-regulation were able to counteract the effect caused by LINC00858 decrease on CC cell proliferation and apoptosis. CONCLUSION: LINC00858 enhances cell proliferation, while restraining cell apoptosis in CC through targeting miR-3064-5p/VMA21 axis, implying that LINC00858 may serve as a promising therapeutic target for CC.

miR-124: A Promising Therapeutic Target for Central Nervous System Injuries and Diseases

2021 ◽  
Author(s):  
Jinying Xu ◽  
Yangyang Zheng ◽  
Liangjia Wang ◽  
Yining Liu ◽  
Xishu Wang ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Therapeutic Target ◽  
Promising Therapeutic Target

Hypoxia Conditioning as a Promising Therapeutic Target in Parkinson's Disease?

2021 ◽  
Author(s):  
Johannes Burtscher ◽  
Muhammed Muazzam Kamil Syed ◽  
Hilal A. Lashuel ◽  
Grégoire P. Millet
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Therapeutic Target ◽  
Promising Therapeutic Target

scholarly journals HDAC8: A Promising Therapeutic Target for Acute Myeloid Leukemia

2020 ◽  
Vol 8 ◽  
Author(s):  
Marco Spreafico ◽  
Alicja M. Gruszka ◽  
Debora Valli ◽  
Mara Mazzola ◽  
Gianluca Deflorian ◽  
...  
Keyword(s):  
Acute Myeloid Leukemia ◽  
Therapeutic Target ◽  
Myeloid Leukemia ◽  
Promising Therapeutic Target ◽  
Acute Myeloid

Annexin A4 is a promising therapeutic target for the treatment of platinum-resistant cancers

2014 ◽  
Vol 18 (4) ◽  
pp. 403-414 ◽  
Author(s):  
Shinya Matsuzaki ◽  
Satoshi Serada ◽  
Akiko Morimoto ◽  
Yutaka Ueda ◽  
Kiyoshi Yoshino ◽  
...  
Keyword(s):  
Therapeutic Target ◽  
Annexin A4 ◽  
Platinum Resistant ◽  
Promising Therapeutic Target

scholarly journals The polycomb group protein enhancer of zeste 2 is a novel therapeutic target for cervical cancer

2015 ◽  
Vol 42 (5) ◽  
pp. 458-464 ◽  
Author(s):  
Muyang Ding ◽  
Hang Zhang ◽  
Zhen Li ◽  
Cuili Wang ◽  
Jasmine Chen ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Therapeutic Target ◽  
Polycomb Group ◽  
Polycomb Group Protein ◽  
Enhancer Of Zeste ◽  
Group Protein ◽  
Novel Therapeutic
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