Clinical benefits of a skin care regimen with PPARs, retinol, and AHAs in a double-blind, split-face application, vehicle-controlled study

Studies have shown that stem cells and their derivatives, including conditioned media (CM), have inhibitory effects on skin pigmentation. However, evidence supporting the skin brightening effect of exosomes derived from stem cells is lacking. We studied the antipigmentation effect in vitro and skin brightening efficacy in vivo of exosomes derived from human adipose tissue-derived mesenchymal stem/stromal cells (ASC-exosomes). Exosomes were isolated from the CM of ASCs using the tangential flow filtration method. ASC-exosomes reduced intracellular melanin levels in B16F10 melanoma cells regardless of the presence of the α-melanocyte-stimulating hormone (α-MSH). The skin brightening efficacy of a cosmetic formulation containing ASC-exosomes was assessed in human volunteers with hyperpigmentation in a prospective, split-face, double-blind, randomized placebo-controlled study. The ASC-exosome-containing formulation statistically decreased the melanin contents compared to the placebo control. However, the melanin-reduction activity was limited and diminished along with time. A further improvement in efficient transdermal delivery of ASC-exosomes will be helpful for more profound efficacy. In summary, these results suggest that ASC-exosomes can be used as a cosmeceutical for skin brightening.

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Effect of green tea extract loaded chitosan microparticles on facial skin: A split‐face, double‐blind, randomized placebo‐controlled study

Journal of Cosmetic Dermatology ◽

10.1111/jocd.14707 ◽

2021 ◽

Author(s):

Wudtichai Wisuitiprot ◽

Kornkanok Ingkaninan ◽

Sirada Jones ◽

Neti Waranuch

Keyword(s):

Green Tea ◽

Green Tea Extract ◽

Controlled Study ◽

Facial Skin ◽

Double Blind ◽

Chitosan Microparticles ◽

Tea Extract ◽

Split Face

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Preoperative Rectal Indomethacin for Analgesia after Laparoscopic Sterilisation

Anaesthesia and Intensive Care ◽

10.1177/0310057x9202000311 ◽

1992 ◽

Vol 20 (3) ◽

pp. 337-340 ◽

Cited By ~ 26

Author(s):

S. Crocker ◽

M. Paech

Keyword(s):

Postoperative Pain ◽

Controlled Study ◽

Day Case ◽

Double Blind ◽

Double Blind Placebo ◽

Pain Scores ◽

Preoperative Administration ◽

Subjective Pain ◽

Clinical Benefits ◽

Rectal Indomethacin

A randomised, double-blind, placebo-controlled study was conducted among 56 day-case patients to determine the effect of the preoperative administration of rectal indomethacin on postoperative pain and opioid requirements after laparoscopic sterilisation. Outcome in women receiving indomethacin did not differ significantly from the placebo group, but there was a trend to lower subjective pain scores, reduction in early postoperative pain assessed objectively and lower parenteral pethidine requirements in the first three hours postoperatively. Indomethacin did not appear either to cause side-effects or to significantly reduce morbidity from the other postoperative sequelae of laparoscopy. Despite evidence for postoperative analgesic effect, the clinical benefits of premedication with rectal indomethacin were minor.

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