Correlation of serum vitamin D level with severity of atopic dermatitis and the impact of vitamin D supplementation on treatment outcome

Diabetes is one of the commonest chronic diseases worldwide. Vitamin D deficiency showed to be increasing, and have a potential role in autoimmune diseases among which in type 1 diabetes. The aim The aim of the study was to assess the impact of oral vitamin D supplementation on blood glucose (HbA1C) in T1DM patients and to find out the role of vitamin D as a biomarker for follow of T1DM patients compared to HbA1C. Subjects and methods: A randomized interventional clinical study was designed. The study enrolled 60 children patients with T1DM. Only 45 children continued to the end of study. Initial (pre-intake) assessment included history taking, clinical examination, and measurement of serum 25-OH vitamin D3 and serum HbA1C. These children received oral vitamin D supplements for 3 months then post-intake assessment were done again. Results: The study showed that serum vitamin D was deficient among Egyptian children and adolescents with T1DM (mean 11.4±3.4 ng/ml). , 53.33% of the patients had vitamin D deficiency with a 35.6% had insufficiency and 11.11% were VD sufficient. Patients received oral vitamin D supplementation for 3 months after which marked improvement in the levels of serum vitamin D levels and HA1C, 87.5% and 86.5% respectively.

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Does Serum Vitamin D Concentration Modify the Association Between Arthritis and Cardiovascular Diseases in Both Sexes?

10.21203/rs.3.rs-35271/v1 ◽

2020 ◽

Author(s):

Rachelle Saade ◽

Danielle Laurin ◽

Clermont E. Dionne

Keyword(s):

Vitamin D ◽

Cardiovascular Diseases ◽

Protective Factors ◽

Inflammatory Arthritis ◽

Serum Vitamin ◽

Vitamin D Supplementation ◽

Cross Sectional ◽

Men And Women ◽

Serum Vitamin D ◽

The Impact

Abstract Background: The scientific literature shows an association between inflammatory arthritis and cardiovascular diseases (CVD) with inflammation being a shared characteristic between the two types of diseases. Among patients with arthritis, it is possible that the protective factors against inflammation, such as vitamin D, are also protective factors against the development of CVD. This effect may be different according to sex.Objective: To evaluate the impact of serum vitamin D concentration on the association between arthritis and CVD separately among men and women (effect modification of vitamin D and sex).Methods: Data came from a large representative sample of the US population: the National Health and Nutrition Examination Survey (NHANES) 2005-2006, which included 3406 adults aged between 20 and 69 years. Measurements of arthritis (primary independent variable) and CVD (dependent variable) were taken during face-to-face interviews, while the measurement of serum vitamin D was carried out on blood samples. Multivariate logistic regression analyses were performed in which the combined modifying effect of vitamin D (<20 ng/ml/> 20 ng/ml) and sex was tested, and adjusted for several potentially confounding variables.Results: Arthritis was statistically associated with CVD in both men and women, with <20 ng/ml or >20 ng/ml serum vitamin D. In men, the adjusted ratio of the odds ratios (ROR) comparing the association at <20 ng/ml vitamin D concentration to the association at >20 ng/ml concentration was 0.8 (95% CI 0.5 to 1.5); in women, the adjusted ROR was 0.7 (95% CI 0.3 to 1.5). Conclusions: In this large cross-sectional study, arthritis and CVD were statistically associated, but this association was not modified by sex nor vitamin D concentrations. Vitamin D supplementation is not recommended as part of the management of patients of both sexes suffering from inflammatory arthritis to prevent CVD.

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The impact of vitamin D supplementation on body fat mass in elite male collegiate athletes

Nutrition & Metabolism ◽

10.1186/s12986-021-00578-9 ◽

2021 ◽

Vol 18 (1) ◽

Author(s):

Itaru Kawashima ◽

Takashi Tsukahara ◽

Ryosuke Kawai ◽

Takafumi Mizuno ◽

Shinya Ishizuka ◽

...

Keyword(s):

Vitamin D ◽

Body Fat ◽

Serum Vitamin ◽

Collegiate Athletes ◽

Vitamin D Supplementation ◽

Body Fat Percentage ◽

Fat Percentage ◽

Serum Vitamin D ◽

Supplement Group ◽

The Impact

Abstract Background Whether vitamin D supplementation has any effect on body fat percentage, especially among elite athletes, remains unclear. The aim of this study was to evaluate the effect of vitamin D supplementation on serum vitamin D level in elite male collegiate athletes and to analyze its effect on body fat percentage. Methods We enrolled a total of 42 elite male collegiate athletes in this prospective cohort study. In March 2020, body composition monitoring and blood test were performed. All athletes were provided with vitamin D3 supplement tablets of 25 μg/day. The use of the supplement was dependent on athletes’ preference. During the study period, their club activities were stopped for 2 months due to the coronavirus disease 2019 outbreak. A second examination, similar to the first one, was performed after approximately 3 months. Supplement usage by each athlete was also confirmed. The participants were divided into a non-supplement group (without supplementation, n = 15) and a supplement group (with supplementation, n = 27). Results Regarding baseline data at initial examination, the non-supplement and supplement groups showed significant differences in the mean body fat percentage (9.0% and 12.1%, respectively; P = 0.03) and serum 25(OH)D level (22.7 and 18.5 ng/mL, respectively, P = 0.02). At the time of the second examination, there were no significant differences in the results of both the groups. In terms of mean change value from the first to the second examination, there were significant differences in body fat percentage (1.9 and 0.2%, respectively, P = 0.02) and serum 25(OH)D level (1.7 and 7.2 ng/mL, respectively, P < 0.001) between the two groups. A significant negative correlation was observed between the change ratio of body fat percentage and change value of serum 25(OH)D level (r = − 0.37, P = 0.02). Conclusions Vitamin D supplementation of 25 μg/day significantly increased the serum 25(OH)D level in elite male collegiate athletes. Vitamin D supplementation may play a role in maintaining athletes’ body fat percentage under circumstances where sports activity has decreased.

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Serum vitamin D level in Egyptian children with atopic dermatitis and efficacy of vitamin D supplementation

Journal of the Egyptian Womenʼs Dermatologic Society ◽

10.1097/01.ewx.0000516170.33041.a5 ◽

2017 ◽

Vol 14 (3) ◽

pp. 190-196 ◽

Cited By ~ 1

Author(s):

Bothaina M. Ghanem ◽

Hanan A. Salem ◽

Hamdy F. Marzouk ◽

Amira E.Y. Ismail

Keyword(s):

Vitamin D ◽

Atopic Dermatitis ◽

Serum Vitamin ◽

Vitamin D Supplementation ◽

Serum Vitamin D ◽

Egyptian Children

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Evaluation of the hormonal and biochemical changes in obese and non-obese PCOS Iraqi women before and after vitamin D supplementation

International Journal of Drug Delivery Technology ◽

10.25258/ijddt.v9i3.2 ◽

2019 ◽

Vol 9 (o3) ◽

Author(s):

Suaad Muhssen Ghazi ◽

Fatin Shallal Farhan

Keyword(s):

Vitamin D ◽

Serum Vitamin ◽

Follicular Development ◽

High Body Mass Index ◽

Vitamin D Supplementation ◽

The Body ◽

Obese People ◽

Serum Vitamin D ◽

Before And After ◽

Granulose Cells

Vitamin D deficiency is common in women with polycystic ovarian syndrome. Vitamin D plays an important physiologic role in reproductive functions of ovarian follicular development and luteinization through altering anti-müllerian hormone signaling, follicular stimulating hormone activity and progesterone production in human granulose cells. Vitamin D is precipitated in adipose fat tissues, making it notable to be used for the body as a result; obese people with high body mass index are already highly expected to have low levels of serum vitamin D.

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Using genetic variants to evaluate the causal effect of serum vitamin D concentration on COVID-19 susceptibility, severity and hospitalization traits: a Mendelian randomization study

Journal of Translational Medicine ◽

10.1186/s12967-021-02973-5 ◽

2021 ◽

Vol 19 (1) ◽

Author(s):

Zhiyong Cui ◽

Yun Tian

Keyword(s):

Vitamin D ◽

Fixed Effects ◽

Mendelian Randomization ◽

Causal Effect ◽

Serum Vitamin ◽

Vitamin D Supplementation ◽

Sensitivity Analyses ◽

Global Test ◽

Serum Vitamin D

Abstract Background The coronavirus disease 2019 (COVID-19) pandemic has struck globally and is exerting a devastating toll on humans. The pandemic has led to calls for widespread vitamin D supplementation in public. However, evidence supporting the role of vitamin D in the COVID-19 pandemic remains controversial. Methods We performed a two-sample Mendelian randomization (MR) analysis to analyze the causal effect of the 25-hydroxyvitamin D [25(OH)D] concentration on COVID-19 susceptibility, severity and hospitalization traits by using summary-level GWAS data. The causal associations were estimated with inverse variance weighted (IVW) with fixed effects (IVW-fixed) and random effects (IVW-random), MR-Egger, weighted edian and MR Robust Adjusted Profile Score (MR.RAPS) methods. We further applied the MR Steiger filtering method, MR Pleiotropy RESidual Sum and Outlier (MR-PRESSO) global test and PhenoScanner tool to check and remove single nucleotide polymorphisms (SNPs) that were horizontally pleiotropic. Results We found no evidence to support the causal associations between the serum 25(OH)D concentration and the risk of COVID-19 susceptibility [IVW-fixed: odds ratio (OR) = 0.9049, 95% confidence interval (CI) 0.8197–0.9988, p = 0.0473], severity (IVW-fixed: OR = 1.0298, 95% CI 0.7699–1.3775, p = 0.8432) and hospitalized traits (IVW-fixed: OR = 1.0713, 95% CI 0.8819–1.3013, p = 0.4878) using outlier removed sets at a Bonferroni-corrected p threshold of 0.0167. Sensitivity analyses did not reveal any sign of horizontal pleiotropy. Conclusions Our MR analysis provided precise evidence that genetically lowered serum 25(OH)D concentrations were not causally associated with COVID-19 susceptibility, severity or hospitalized traits. Our study did not provide evidence assessing the role of vitamin D supplementation during the COVID-19 pandemic. High-quality randomized controlled trials are necessary to explore and define the role of vitamin D supplementation in the prevention and treatment of COVID-19.

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Low serum vitamin D, statin associated muscle symptoms, vitamin D supplementation

Atherosclerosis ◽

10.1016/j.atherosclerosis.2016.11.027 ◽

2017 ◽

Vol 256 ◽

pp. 125-127 ◽

Cited By ~ 6

Author(s):

Charles J. Glueck ◽

Kevin Lee ◽

Marloe Prince ◽

Alexander Milgrom ◽

Frini Makadia ◽

...

Keyword(s):

Vitamin D ◽

Serum Vitamin ◽

Vitamin D Supplementation ◽

Serum Vitamin D ◽

Low Serum

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Causal analysis shows evidence of atopic dermatitis leading to an increase in vitamin D levels

10.1101/2020.04.22.20075077 ◽

2020 ◽

Author(s):

Daniel R Drodge ◽

Ashley Budu-Aggrey ◽

Lavinia Paternoster

Keyword(s):

Vitamin D ◽

Atopic Dermatitis ◽

Serum Vitamin ◽

Strong Relationship ◽

Reverse Direction ◽

Serum Vitamin D ◽

Vitamin D Levels ◽

Standard Deviations ◽

The Relationship ◽

Gwa Studies

AbstractAtopic dermatitis (AD) patients have been observed to have lower vitamin D levels. Previous studies have found little evidence that vitamin D levels causally influence the risk of AD, but the reverse direction has not yet been investigated.Here we used Mendelian Randomization to assess the causal relationship between AD and serum vitamin D levels, using genetic data from the most recent GWA studies of vitamin D and AD.There was little evidence for vitamin D levels causally influencing AD risk (odds per standard deviations increase in log-transformed vitamin D levels =1.233, 95% CI 0.927 to 1.639, P-value =0.150). However, genetic liability for AD raises serum vitamin D levels by 0.043 (95% CI 0.017 to 0.069) standard deviations per doubling of odds of disease (P-value =0.001). The AD-associated filaggrin (FLG) mutation R501X appears to show a particularly strong relationship with vitamin D. However, the relationship between AD and vitamin D holds when R501X is omitted (0.018, 95% CI 0.004 to 0.031, P-value =0.008).We found evidence that AD is causally associated with an increase in serum vitamin D levels. Whilst the AD-associated FLG gene has a particularly strong relationship with vitamin D, other AD SNPs show a consistent direction of effect, suggesting that AD more generally influences serum vitamin D levels.

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