GW26-e2122 Predictive Value of HbA1c on left atrial thrombus or Left Atrial Spontaneous Echo Contrast in Non-Valvular Atrial Fibrillation Patients

Objective. This meta-analysis aimed at exploring the predictive value of CHA2DS2-VASc score for the left atrial thrombus (LAT) or left atrial spontaneous echo contrast (LASEC) in patients with nonvalvular atrial fibrillation (NVAF). Methods. PubMed, Embase, Web of Science, ScienceDirect, Cochrane Library, and Chinese core journals of the CNKI and Wanfang databases were searched to identify all the relevant papers that were published up to January 2020. The data were extracted for pooled odds ratios (ORs) with 95% confidence intervals (CIs), heterogeneity, subgroup, publication bias, and sensitivity analysis. Results. Overall, 15 studies containing 6223 patients with NVAF were enrolled. All studies were evaluated for LAT, and 12 studies were evaluated for LASEC. The pooled analysis using a random-effects model showed that a high CHA2DS2-VASc score was related with LAT/LASEC (pooled OR=1.59, 95% CI: 1.35–1.88, P<0.001) with high heterogeneity (I2=76.9%, P<0.001) and LAT (pooled OR=1.83, 95% CI: 1.44–2.33, P<0.001) with high heterogeneity (I2=79.4%, P<0.001). The subgroup analysis demonstrated that the sample size may be the main source of heterogeneity. Although the Begg’s funnel plot based on 15 studies for LAT/LASEC (P=0.029) and 12 studies for LAT (P=0.046) indicated the presence of publication bias among the included studies, the trim-and-fill method verified the stability of the pooled outcomes. In addition, sensitivity analysis indicated that all effects were stable. Conclusion. The results of this meta-analysis showed that the CHA2DS2-VASc score is related with LAT and LASEC in patients with NVAF. However, more studies are warranted to address this issue.

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Prevalence of Left Atrial Thrombus and Dense Spontaneous Echo Contrast in Patients With Short-Term Atrial Fibrillation < 48 Hours Undergoing Cardioversion: Value of Transesophageal Echocardiography to Guide Cardioversion

Journal of the American Society of Echocardiography ◽

10.1016/j.echo.2009.09.015 ◽

2009 ◽

Vol 22 (12) ◽

pp. 1403-1408 ◽

Cited By ~ 44

Author(s):

Thomas Kleemann ◽

Torsten Becker ◽

Margit Strauss ◽

Steffen Schneider ◽

Karlheinz Seidl

Keyword(s):

Atrial Fibrillation ◽

Transesophageal Echocardiography ◽

Left Atrial ◽

Left Atrial Thrombus ◽

Short Term ◽

Atrial Thrombus ◽

Spontaneous Echo Contrast

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GW25-e3093 Predictive value of serum uric acid level for left atrial thrombus or spontaneous echo contrast in patients with atrial fibrillation

Journal of the American College of Cardiology ◽

10.1016/j.jacc.2014.06.1094 ◽

2014 ◽

Vol 64 (16) ◽

pp. C235

Author(s):

Liu Fangzhou ◽

Wei Wei ◽

Xue Yumei ◽

Zhan Xianzhang ◽

Fang Xianhong ◽

...

Keyword(s):

Atrial Fibrillation ◽

Uric Acid ◽

Serum Uric Acid ◽

Uric Acid Level ◽

Predictive Value ◽

Left Atrial ◽

Acid Level ◽

Serum Uric Acid Level ◽

Left Atrial Thrombus ◽

Atrial Thrombus

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Cardiovascular death in patients with atrial fibrillation is better predicted by left atrial thrombus and spontaneous echo contrast as compared to clinical parameters

Journal of the American College of Cardiology ◽

10.1016/s0735-1097(98)82179-7 ◽

1998 ◽

Vol 31 ◽

pp. 354

Author(s):

B. Dawn ◽

P. Singh ◽

M.F. Stoddard ◽

R.A. Longaker

Keyword(s):

Atrial Fibrillation ◽

Left Atrial ◽

Cardiovascular Death ◽

Clinical Parameters ◽

Left Atrial Thrombus ◽

Atrial Thrombus ◽

Spontaneous Echo Contrast

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Nomogram to Predict Left Atrial Thrombus or Spontaneous Echo Contrast in Patients With Non-valvular Atrial Fibrillation

Frontiers in Cardiovascular Medicine ◽

10.3389/fcvm.2021.737551 ◽

2021 ◽

Vol 8 ◽

Author(s):

Zhitong Li ◽

Quanbo Liu ◽

Fei Liu ◽

Tesfaldet H. Hidru ◽

Yuqi Tang ◽

...

Keyword(s):

Atrial Fibrillation ◽

Left Atrial ◽

Left Ventricular ◽

Left Ventricular Ejection ◽

Individual Risk ◽

Good Prediction ◽

Left Atrial Thrombus ◽

Atrial Thrombus ◽

Ventricular Ejection Fraction ◽

Spontaneous Echo Contrast

Background: The predictive power of the CHADS2 and CHA2DS2-VASc scores for the presence of Left atrial thrombus (LAT)/ spontaneous echo contrast (SEC) in non-valvular atrial fibrillation (NVAF) is modest. The aim of this analysis is to define clinical and ultrasonic variables associated with LAT/SEC and to propose nomograms for individual risk prediction.Methods: Data on 1,813 consecutive NVAF patients who underwent transesophageal echocardiography (TEE) from January 2016 to January 2021 were collected. The univariate and multivariate logistic regression analyses were used to construct a nomogram. We examined the predictive ability of the risk scores by calculating the area under the curve (AUC). Moreover, the performance of the nomogram was assessed with respect to calibration, discrimination, and clinical usefulness.Results: LAT/SEC was found in 260 (21.0%) and 124 (21.6%) patients in the training and validation cohorts, respectively. On multivariate analysis, independent factors for LAT/SEC were Age, left atrial diameter (LAD), left ventricular ejection fraction (LVEF), hypertension (HTN), previous stroke or transient ischemic attack, Non-paroxysmal AF and a nomogram was built based on these variables. The calibration curve for the probability of LAT/SEC showed good prediction agreement with actual observation. The nomogram achieved good concordance indexes of 0.836 and 0.794 in predicting LAT/SEC in the training and validation cohorts, respectively. Decision curve analysis demonstrated that the nomogram would be clinically useful.Conclusions: In this study, a nomogram was constructed that incorporated six characteristics of NVAF patients. The nomogram may be of great value for the prediction of LAT/SEC in NVAF patients.

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