scholarly journals Myocardial Interstitial Fibrosis in Nonischemic Heart Disease, Part 3/4

2020 ◽  
Vol 75 (17) ◽  
pp. 2204-2218 ◽  
Author(s):  
Javier Díez ◽  
Arantxa González ◽  
Jason C. Kovacic
Keyword(s):  
Heart Disease ◽  
Interstitial Fibrosis ◽  
Myocardial Interstitial Fibrosis

scholarly journals Evolution of biventricular T1 values in patients with right-sided congenital heart disease

2021 ◽  
Vol 22 (Supplement_1) ◽  
Author(s):  
O Burdet ◽  
AG Pavon ◽  
J Bouchardy ◽  
C Blanche ◽  
P Monney ◽  
...  
Keyword(s):  
Congenital Heart Disease ◽  
Heart Disease ◽  
Congenital Heart ◽  
Interstitial Fibrosis ◽  
Pulmonary Stenosis ◽  
Pulmonary Regurgitation ◽  
Native T1 ◽  
Funding Sources ◽  
Basal Slice ◽  
Relationship Of

Abstract Funding Acknowledgements Type of funding sources: None. Background Conflicting reports exist on the prevalence and clinical impact of interstitial fibrosis in right ventricular (RV) congenital heart disease (CHD). This study evaluates the longitudinal evolution of native myocardial T1 relaxation time (T1) in RV CHD. Methods On a 1.5T scanner, an ECG-triggered modified Look-Locker inversion recovery sequence (scheme 3(3)3(3)5) was acquired on a short-axis basal slice covering the RV and left ventricle (LV) on two consecutive CMR exams. Global and segmental (LV = 6, RV = 4) RV and LV T1 values  were calculated (Figure). Results Mean time between CMR exams for 36 included patients (age 34 ± 2y) was 22 ± 2 months. All LV segments and 81/88% of RV segments of first and second CMR could be analyzed, respectively.  T1 increased mildly but not significantly (table). There was no relationship of T1 to pulmonary regurgitation fraction, pulmonary stenosis or RV enddiastolic volume (p > 0.05). Global RV T1 of the second CMR was related to RV ejection fraction (RVEF): r = 0.353, 3.0 ± 1.4, p = 0.038. T1 of the infero-septal LV segment of first and second CMR, global LV T1 of second CMR and increase of T1 of global LV, anterior, antero-lateral and –septal LV segments, were related to age at CMR: r = 0.333 - 0.463, p < 0.05, respectively. Conclusions Native T1 values increased mildly in patients with stable RV CHD, which was not statistically significant probably due to the short to median follow-up. Global RV T1 appears to be related to RVEF which could be sign of increasing interstitial fibrosis whereas the relationship of LV T1 to age might be a physiological finding. First CMR native T1 (ms) Second CMR native T1 (ms) p LV Global 1007 ± 37 1014 ± 39 0.413 LV Anterior 994 ± 53 999 ± 54 0.710 LV Antero-lateral 965 ± 63 981 ± 58 0.186 LV Infero-lateral 1000 ± 52 1004 ± 63 0.695 LV Inferior 1035 42 1037 ± 50 0.744 LV Infero-septal 1028 ± 35 1036 ± 43 0.282 LV Antero-septal 1016 ± 38 1024 ± 48 0.347 RV Global 1091 ± 90 1096 ± 85 0.410 RV Inferior 1112 ± 104 1115 ± 118 0.696 RV Infero-lateral 1061 ± 130 1077 ± 115 0.425 RV Antero-lateral 1046 ± 127 1080 ± 109 0.088 RV Anterior 1088 ± 156 1108 ± 154 0.410 Abstract Figure. Determination of biventricular T1 values

scholarly journals Myocardial Interstitial Fibrosis in Heart Failure

2018 ◽  
Vol 71 (15) ◽  
pp. 1696-1706 ◽  
Author(s):  
Arantxa González ◽  
Erik B. Schelbert ◽  
Javier Díez ◽  
Javed Butler
Keyword(s):  
Heart Failure ◽  
Interstitial Fibrosis ◽  
Myocardial Interstitial Fibrosis

scholarly journals Prognostic Impact of Myocardial Interstitial Fibrosis in Non-Ischemic Heart Failure

2011 ◽  
Vol 75 (11) ◽  
pp. 2605-2613 ◽  
Author(s):  
Tatsuo Aoki ◽  
Yoshihiro Fukumoto ◽  
Koichiro Sugimura ◽  
Minako Oikawa ◽  
Kimio Satoh ◽  
...  
Keyword(s):  
Heart Failure ◽  
Interstitial Fibrosis ◽  
Ischemic Heart ◽  
Prognostic Impact ◽  
Ischemic Heart Failure ◽  
Myocardial Interstitial Fibrosis

scholarly journals Cardiac remodeling and MMPs on the model of chronic daunorubicin-induced cardiomyopathy in rabbits

2010 ◽  
pp. 831-836
Author(s):  
M Adamcová ◽  
A Potáčová ◽  
O Popelová ◽  
M Štěrba ◽  
Y Mazurová ◽  
...  
Keyword(s):  
Cardiac Remodeling ◽  
Biochemical Analysis ◽  
Interstitial Fibrosis ◽  
Morphological Changes ◽  
Immunohistochemical Analysis ◽  
Treated Group ◽  
Insoluble Fraction ◽  
Anthracycline Cardiotoxicity ◽  
Myocardial Interstitial Fibrosis ◽  
The Matrix

The matrix metalloproteinases (MMPs) play a key role during cardiac remodeling. The aim of the study was to investigate the changes in collagenous proteins and MMPs in the model of non-ischemic, anthracycline-induced chronic cardiomyopathy in rabbits using both biochemical and histological approaches. The study was carried out in three groups of Chinchilla male rabbits: 1) daunorubicin (3 mg/kg, once weekly for 10 weeks), 2) control (saline in the same schedule), 3) daunorubicin with the cardioprotectant dexrazoxane (60 mg/kg, before each daunorubicin). Morphological changes in the myocardium of daunorubicin-treated animals were characterized by focal myocardial interstitial fibrosis of different intensity. The subsequent proliferation of the fibrotic tissue was marked by an increased content of both collagen types I and III, which resulted in their typical coexpression in the majority of bundles of fibers forming either smaller or larger scars. Biochemical analysis showed a significantly increased concentration of hydroxyproline, mainly in the pepsin-insoluble fraction of collagenous proteins, in the daunorubicin-treated group (1.42±0.12 mg/g) as compared with the control (1.03±0.04 mg/g) and dexrazoxane (1.07±0.07 mg/g) groups. Dexrazoxane co-administration remarkably reduced the cardiotoxic effects of daunorubicin to the extent comparable with the controls in all evaluated parameters. Using zymography, it was possible to detect only a gelatinolytic band corresponding to MMP-2 (MMP-9 activity was not detectable). However, no significant changes in MMP-2 activity were determined between individual groups. Immunohistochemical analysis revealed increased MMP-2 expression in both cardiomyocytes and fibroblasts. Thus, this study has revealed specific alterations in the collagen network in chronic anthracycline cardiotoxicity in relationship to the expression and activity of major MMPs.

Effects of Myocardial Edema on the Development of Myocardial Interstitial Fibrosis

2000 ◽  
Vol 7 (4) ◽  
pp. 269-280 ◽  
Author(s):  
K L DAVIS ◽  
G A LAINE ◽  
H J GEISSLER ◽  
U MEHLHORN ◽  
M BRENNAN ◽  
...  
Keyword(s):  
Interstitial Fibrosis ◽  
Myocardial Edema ◽  
Myocardial Interstitial Fibrosis
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