Vitamin D and food allergy in patients with severe atopic dermatitis

2013 ◽  
Vol 132 (4) ◽  
pp. 1011 ◽  
Author(s):  
Maaz S. Mohiuddin ◽  
Douglas Curran-Everett ◽  
Donald Y.M. Leung
Keyword(s):  
Vitamin D ◽  
Atopic Dermatitis ◽  
Food Allergy ◽  
Severe Atopic Dermatitis

scholarly journals Dupilumab in Moderate-to-Severe Atopic Dermatitis With or Without Comorbid Food Allergy: Pooled Analysis of 2 Randomized Phase 3 Trials (LIBERTY AD SOLO 1 & 2)

2018 ◽  
Vol 141 (2) ◽  
pp. AB131
Author(s):  
Eric L. Simpson ◽  
Jean-Philippe Lacour ◽  
Jonathan I. Silverberg ◽  
Margitta Worm ◽  
Andreas Wollenberg ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Food Allergy ◽  
Pooled Analysis ◽  
Severe Atopic Dermatitis ◽  
Phase 3

scholarly journals Successful Treatment of Severe Atopic Dermatitis with Calcitriol and Paricalcitol in an 8-Year-Old Girl

2018 ◽  
Vol 2018 ◽  
pp. 1-5
Author(s):  
Christina Bothou ◽  
Alexis Alexopoulos ◽  
Eleni Dermitzaki ◽  
Kleanthis Kleanthous ◽  
Anastasios Papadimitriou ◽  
...  
Keyword(s):  
Vitamin D ◽  
Atopic Dermatitis ◽  
Skin Inflammation ◽  
Skin Lesions ◽  
Chronic Inflammatory Disease ◽  
Vitamin D Supplementation ◽  
Severe Atopic Dermatitis ◽  
Efficacious Treatment ◽  
Children And Adolescence ◽  
Therapy Treatment

Atopic dermatitis (AD) is a chronic inflammatory disease affecting children and adolescence. The traditional therapeutic options for AD, including emollients topically and immune modulatory agents systemically focusing on reducing skin inflammation and restoring the function of the epidermal barrier, are proven ineffective in many cases. Several studies have linked vitamin D supplementation with either a decreased risk to develop AD or a clinical improvement of the symptoms of AD patients. In this report, we present a girl with severe AD who under adequate supplementation with cholecalciferol was treated with calcitriol and subsequently with paricalcitol. She had significant improvement—almost healing of her skin lesions within 2 months, a result sustained for more than 3 years now. Because of hypercalciuria as a side effect from calcitriol therapy, treatment was continued with paricalcitol, a vitamin D analogue used in secondary hyperparathyroidism in chronic kidney disease. Calcitriol therapy may be considered as a safe and efficacious treatment option for patients with severe AD, particularly for those with refractory AD, under monitoring for possible side effects. Treatment with paricalcitol resolves hypercalciuria, is safe, and should be further investigated as an alternative treatment of atopic dermatitis and possibly other diseases of autoimmune origin.

scholarly journals Food allergen-free diet in severe atopic dermatitis related to food allergy

2011 ◽  
Vol 77 (3) ◽  
pp. 332 ◽  
Author(s):  
Vasileios Anyfantakis ◽  
Gerard Guillet ◽  
Guillet Marie-Helene
Keyword(s):  
Atopic Dermatitis ◽  
Food Allergy ◽  
Food Allergen ◽  
Severe Atopic Dermatitis

scholarly journals PECULIARITIES OF CLINICAL PASSING OF ATOPIC DERMATITIS AND VITAMIN D EXCHANGE IN EARLY CHILDREN

2020 ◽  
pp. 27-35
Author(s):  
N. V. Kamut ◽  
M. M. Kiselova
Keyword(s):  
Vitamin D ◽  
Atopic Dermatitis ◽  
Young Children ◽  
Clinical Manifestations ◽  
Serum Vitamin ◽  
Scientific Data ◽  
Main Group ◽  
Severe Atopic Dermatitis ◽  
Serum Vitamin D ◽  
Vitamin D Levels

The article is devoted to the study of features of clinical course of atopic dermatitis and vitamin D exchange in young children conducted by us by estimation of severity of atopic dermatitis depending on the value of SCORAD index, determination of 25(OH)D concentration in serum of children by immunochemical method with chemocentric analysis according to the classification approved by experts of the international endocrinological society. In the examination of 188 young children, two groups were formed on the basis of the Lviv City Children's Clinical Hospital. Children from 1 month to 1 year of age with manifestations of atopic dermatitis (n = 120), who were born full-term and had no birth defects, metabolic disorders, severe perinatal CNS lesions formed the main group. The comparison group consisted of 68 healthy young children without chronic diseases. All children had atopic dermatitis in the main group and were classified by severity (depending on the SCORAD index): children with mild severity – 31 (26 %), moderate 47 (39 %), and severe 42 (35 %). As a result of the study, we found a association between the severity of clinical manifestations of atopic dermatitis and the level of vitamin D in the serum. Comparative analysis of the severity of atopic dermatitis, depending on the level of vitamin D in the serum, showed that with severe atopic dermatitis in children of the main group, the level of 25(OH)D was significantly lower compared to its indicators in children with moderate to severe (P < 0.05). Serum vitamin D levels are significantly lower in all forms of atopic dermatitis severity and correlate significantly with the overall SCORAD severity score, erythema intensity, excoriation, itching, and sleep disturbances. The scientific data on the presence of feedback correlation (r = –0,48; P < 0,05) between the development of atopic dermatitis in children and their level of 25(OH)D in serum were added. Our findings suggest that there is a need for a differentiated approach to treating early-stage atopic dermatitis of varying severity, a personalized therapeutic approach to choosing a vitamin D supplementation, given the level of 25(OH)D in the serum.

scholarly journals IgE Testing Can Predict Food Allergy Status in Patients with Moderate-Severe Atopic Dermatitis

2019 ◽  
Vol 143 (2) ◽  
pp. AB130
Author(s):  
Pamela A. Guerrerio ◽  
Marjohn Rasooly ◽  
Wenjuan Gu ◽  
Samara Levin ◽  
Rekha Jhamnani ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Food Allergy ◽  
Severe Atopic Dermatitis

Skin Manifestations of Food Allergy

PEDIATRICS ◽  
2003 ◽  
Vol 111 (Supplement_3) ◽  
pp. 1617-1624 ◽  
Author(s):  
Wesley Burks
Keyword(s):  
Atopic Dermatitis ◽  
Food Allergy ◽  
Specific Ige ◽  
Rational Approach ◽  
Severe Atopic Dermatitis ◽  
Acute Urticaria ◽  
Skin Response ◽  
Allergic Skin ◽  
Food Challenges ◽  
Food Specific Ige

The pediatrician is faced with evaluating a panoply of skin rashes, a subset of which may be induced by food allergy. Acute urticaria is a common manifestation of an allergic skin response to food, but food is rarely a cause of chronic urticaria. Approximately one third of infants/children with moderate to severe atopic dermatitis have food allergy. Although diagnosis of acute urticaria provoked by a food may be evident from a straightforward history and confirmed by diagnostic tests to detect food-specific IgE antibody, determination of the role of food allergy in patients with atopic dermatitis is more difficult and may require additional diagnostic maneuvers, including elimination diets and oral food challenges. The immunopathologic basis of food-allergic disorders that affect the skin and a rational approach to diagnosis and treatment are discussed. Additional disorders that are caused by or mimic ones caused by food allergy are reviewed.

scholarly journals Alfacalcidol use in complex therapy of atopic dermatitis

2015 ◽  
Vol 96 (6) ◽  
pp. 952-958
Author(s):  
V Yu Pestova
Keyword(s):  
Vitamin D ◽  
Atopic Dermatitis ◽  
Vitamin D Deficiency ◽  
Active Form ◽  
Serum Vitamin ◽  
Clinical Results ◽  
Severe Atopic Dermatitis ◽  
Open Label ◽  
Serum Vitamin D ◽  
Complex Therapy

Aim. To study clinical course of atopic dermatitis and improve dermatosis therapeutic tactics in vitamin D deficiency. Study design - comparative observational open-label study. Methods. 67 patients with a verified «atopic dermatitis» diagnosis were selected to study. Serum calcidol level below 75 nmol/l was observed in 32 patients what was the basis to division of the observed patients into two groups. Conventional therapy (local glucocorticoids and moistening agents, systemic administration of non-specific anti-inflammatory and desensitizing agents) was administered to all patients. Vitamin D active form - alfacalcidol (Alpha D3-Teva) was administered to patients of the second group as a part of complex therapy. Results. Good clinical results have been achieved amid the treatment, in 21 days SCORAD index decreased by 86.56% in the first group, in the second - by 93.63%, with the clinical remission achievement in over 75% of patients in both groups. Atopic dermatitis complex therapy using alfacalcidol contributed to the normalization of the vitamin D concentration (from 42.92±2.87 to 79.26±4.92 nmol/l) and total calcium level (from 1.97±0.4 to 2, 21±0,8 mmol/l), reduced TEWL measurement and increased corneometry results. The therapy did not contribute to the sebometry data change in both groups. Conclusion. Vitamin D deficiency leads to more severe atopic dermatitis course; complex treatment of this disease with alfacalcidol facilitated normalization of serum vitamin D level and tendency to the epidermal barrier recovery, what opens new possibilities in the treatment of atopic dermatitis.

scholarly journals Severe atopic dermatitis in a boy with potato allergy

2020 ◽  
Vol 16 (3) ◽  
pp. 301-305
Author(s):  
Jędrzej Przekora ◽  
◽  
Agata Wawrzyniak ◽  
Anna Bujnowska ◽  
Agnieszka Rustecka ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Food Allergy ◽  
Dietary Intervention ◽  
Paediatric Population ◽  
Specific Ige ◽  
Primary Treatment ◽  
Elimination Diet ◽  
Severe Form ◽  
Severe Atopic Dermatitis ◽  
Skin Prick Tests

Food allergy is an important problem in the paediatric population. Food products that are most likely to induce allergic reactions include cow’s milk, wheat, peanuts, hen’s eggs, fish and seafood. Food-allergy-related diseases include, among other things, atopic dermatitis, urticaria and asthma. Anaphylactic shock is the most severe form of allergic reaction. Intramuscular adrenalin at a dose of 0.01 mg/kg body weight (maximum dose 0.3–0.5 mg) is the primary treatment for anaphylaxis. An elimination diet is the treatment of choice in food allergy. If symptoms persist despite dietary intervention, extended diagnosis using skin prick tests and/or specific IgE measurements should be performed. We present a clinical case of a 2.5-year-old boy with erythroderma secondary to atopic dermatitis, who was referred to our Department due to the lack of improvement after outpatient treatment. It was found during hospital stay that the symptoms were caused by potato allergens.

scholarly journals IgE testing can predict food allergy status in patients with moderate to severe atopic dermatitis

2019 ◽  
Vol 122 (4) ◽  
pp. 393-400.e2 ◽  
Author(s):  
Pamela A. Frischmeyer-Guerrerio ◽  
Marjohn Rasooly ◽  
Wenjuan Gu ◽  
Samara Levin ◽  
Rekha D. Jhamnani ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Food Allergy ◽  
Severe Atopic Dermatitis
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