scholarly journals Determinants of Quality of life (QOL) Among Children Undergoing Oral Food Challenge (OFC) in Canada

2017 ◽  
Vol 139 (2) ◽  
pp. AB57
Author(s):  
Lianne Soller ◽  
Christopher Mill ◽  
Tiffany Wong ◽  
Ingrid Baerg ◽  
Tracy Gonzalez ◽  
...  
Author(s):  
Timothy J. Franxman ◽  
Laura Howe ◽  
Esther Teich ◽  
Matthew J. Greenhawt

2016 ◽  
Vol 137 (2) ◽  
pp. AB135
Author(s):  
Matthew J. Greenhawt ◽  
Christopher E. Couch ◽  
Timothy J. Franxman ◽  
Audrey Dunn Galvin

2020 ◽  
pp. archdischild-2020-319906
Author(s):  
Sarah Burrell ◽  
Nandinee Patel ◽  
Marta Vazquez-Ortiz ◽  
Dianne E. Campbell ◽  
Audrey DunnGalvin ◽  
...  

ObjectiveTo assess the impact of anaphylaxis on health-related quality of life (HRQL) and self-efficacy in food-allergic patients undergoing in-hospital food challenge.DesignSecondary analysis of a randomised controlled trial.SettingSpecialist allergy centre.PatientsPeanut-allergic young people aged 8–16 years.InterventionsDouble-blind, placebo-controlled food challenge to peanut, with HRQL and self-efficacy assessed using validated questionnaire, approximately 2 weeks prior to and 2 weeks after challenge. Where possible, anaphylaxis was treated with self-injected adrenaline (epinephrine).Main outcome measuresChange in HRQL and self-efficacy.Results56 participants had reactions at food challenge, of whom 16 (29%) had anaphylaxis. Overall, there was an improvement in HRQL (mean 2.6 points (95% CI 0.3 to 4.8); p=0.030) and self-efficacy (mean 4.1 points (95% CI 2.4 to 5.9); p<0.0001), independent of whether anaphylaxis occurred. Parents also reported improved HRQL (mean 10.3 points (95% CI 5.9 to 14.7); p<0.0001). We found evidence of discordance between the improvement in HRQL and self-efficacy as reported by young people and that perceived by parents in their child.ConclusionsAnaphylaxis at food challenge, followed by self-administration of injected adrenaline, was associated with an increase in HRQL and self-efficacy in young people with peanut allergy. We found no evidence that the occurrence of anaphylaxis had a detrimental effect. Young people should be encouraged to self-administer adrenaline using their autoinjector device to treat anaphylaxis at in-hospital challenge.Trial registration numberNCT02149719


PLoS ONE ◽  
2020 ◽  
Vol 15 (12) ◽  
pp. e0241648
Author(s):  
Vibha Sharma ◽  
Jennifer Jobrack ◽  
Wendy Cerenzia ◽  
Stephen Tilles ◽  
Robert Ryan ◽  
...  

Rationale Food allergy is documented to result in considerable morbidity, negative impact on quality of life, and substantial medical care costs. Although anecdotal data suggest widely varying practices in the diagnosis and management of food allergies, the diversity and relative frequency of these practices have not been documented. Methods A questionnaire was developed evaluating allergists’ management approaches of individuals with peanut allergy (PA) in Germany (DE), France (FR), and the United Kingdom (UK). Results Here, we report the survey results from a total of 109 allergists from DE, FR and the UK. They reported to confirm PA at initial diagnosis using skin prick test (≥60%), while allergists from DE and FR reported using allergen-specific IgE testing more (>86%) compared to the UK (<50%). At initial diagnosis, oral food challenge was used less in DE (13%) and FR (14%) and very rarely in the UK (3%) to confirm diagnosis. Recognition of acute reactions, use of adrenaline auto-injectors and allergen avoidance were reported to be discussed with the patient/caregiver at the initial office visit by most allergists (>75%). Half of the responders reported assessing the patient’s quality of life. 63% allergists reported retesting for PA resolution at a later date, with 45% allergists indicated to recommend ingestion of a normal serving of peanut regularly upon resolution. Lack of effective PA treatment was reported to be a ‘very significant’ barrier for optimal PA treatment, with allergists being less than ‘moderately familiar’ with data from clinical trials testing new treatments options for PA. Lastly, allergists stated that the severity of patient’s PA ranked as the most important factor in their decision to recommend oral immunotherapy for PA treatment. Conclusions This survey provides essential insights into the practice of allergists and highlights some areas that would inform strategies for education and improving PA healthcare.


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