The advance in Poaceae pollen seasonality pattern may impact allergy treatment practice

AbstractHistamine receptors play important roles in various pathophysiological conditions and are effective targets for anti-allergy treatment, however the mechanism of receptor activation remain elusive. Here, we present the cryo-electron microscopy (cryo-EM) structure of the human H1R in complex with a Gq protein in an active conformation via a NanoBiT tethering strategy. The structure reveals that histamine activates receptor via interacting with the key residues of both transmembrane domain 3 (TM3) and TM6 to squash the binding pocket on the extracellular side and to open the cavity on the intracellular side for Gq engagement in a model of “squash to activate and expand to deactivate”. The structure also reveals features for Gq coupling, including the interaction between intracellular loop 2 (ICL2) and the αN-β junction of Gq/11 protein. The detailed analysis of our structure will provide a framework for understanding G-protein coupling selectivity and clues for designing novel antihistamines.

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A Targeted Literature Review of the Disease Burden in Patients With Symptomatic Peripheral Artery Disease

Angiology ◽

10.1177/0003319719896477 ◽

2019 ◽

Vol 71 (4) ◽

pp. 303-314

Author(s):

Rupert Bauersachs ◽

Sebastian Debus ◽

Mark Nehler ◽

Maria Huelsebeck ◽

Janita Balradj ◽

...

Keyword(s):

Peripheral Artery Disease ◽

Disease Burden ◽

Ankle Brachial Index ◽

Peripheral Artery ◽

Economic Burden Of Disease ◽

Surgical Interventions ◽

Treatment Practice ◽

Patient Profile ◽

Increased Risk ◽

Artery Disease

Patients with peripheral artery disease (PAD) have an increased risk of cardiovascular (CV) and limb events, but the disease is frequently underdiagnosed and treatment options are limited. This review examines the disease burden of symptomatic PAD as well as key guideline recommendations. Publications were identified using the ProQuest portal to access the Medline, Medline In-Process, and Embase databases. Search terms for symptomatic PAD were combined with terms relevant to epidemiology, burden, treatment practice, and physiopathology. Articles in English published between January 2001 and September 2016 were screened according to the population, interventions, comparator, outcomes, and study design criteria. Relevant publications (n = 200) were identified. The reported incidence and prevalence of PAD varied depending on the definitions used and the study populations. Patients generally had a poor prognosis, with an increased risk of mortality, CV, and limb events and decreased quality of life. Guideline recommendations included ankle–brachial index measurements, exercise testing, and angiography for diagnosis and risk factor modification, antiplatelets, cilostazol, exercise therapy, or surgical interventions for treatment, depending on the patient profile. The clinical, humanistic, and economic burden of disease in patients with symptomatic PAD is substantial and needs to be reduced through improved PAD management.

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Assessment of haemophilia treatment practice pattern in Japan

Haemophilia ◽

10.1111/j.1365-2516.2009.02041.x ◽

2009 ◽

Vol 15 (5) ◽

pp. 1032-1038 ◽

Cited By ~ 7

Author(s):

O. ONO ◽

Y. SUZUKI ◽

K. YOSIKAWA ◽

I. WADA ◽

Y. DOI ◽

...

Keyword(s):

Practice Pattern ◽

Treatment Practice

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Permanent Mold Casting Practice and Microstructure and Mechanical Properties of Thin-Sectioned ADI Casting

Advanced Materials Research ◽

10.4028/www.scientific.net/amr.26-28.531 ◽

2007 ◽

Vol 26-28 ◽

pp. 531-534

Author(s):

B.M. Moon ◽

Bong Hwan Kim ◽

Je Sik Shin ◽

Sang Mok Lee

Keyword(s):

Mechanical Properties ◽

Heat Treatment ◽

Ductile Cast Iron ◽

Treatment Temperature ◽

Chemical Compositions ◽

Permanent Mold ◽

Permanent Mold Casting ◽

Treatment Practice ◽

Mold Casting ◽

Si Content

For thin-walled casting development of austempered ductile iron (ADI), permanent mold casting and accompanied heat treatment practice were systematically investigated to suppress and/or remove chill defects of ductile cast iron (DCI) with various thickness of 2 to 9 mm and to ensure mechanical properties of the final ADI casting. Si content was increased up to 3.8% to reduce the chill formation tendency under a high cooling rate. The residual Mg content remarkably affected the nodule count, while the nodule size and spherodization were proven to have weak relationships. Austenitizing process followed by austempering was very sensitive to chemical compositions (Si and Sn) and heat treatment temperature. As a practical application, the steel bar coupler for a structural frame was tried to produce without subsequent machining.

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