scholarly journals Epithelial repair in asthma: Defect or exaggerated?

2022 ◽  
Author(s):  
Carl Persson
Keyword(s):  
Epithelial Repair

The Human Endogenous Antimicrobial Peptide Ll-37 Stimulates Airway Epithelial Repair

Pneumologie ◽  
2006 ◽  
Vol 59 (12) ◽  
Author(s):  
R Shaykhiev ◽  
C Beißwenger ◽  
K Kändler ◽  
J Senske ◽  
A Püchner ◽  
...  
Keyword(s):  
Antimicrobial Peptide ◽  
Airway Epithelial ◽  
Epithelial Repair

scholarly journals Macrophage-derived EDA-A2 inhibits intestinal stem cells by targeting miR-494/EDA2R/β-catenin signaling in mice

2021 ◽  
Vol 4 (1) ◽  
Author(s):  
Lele Song ◽  
Renxu Chang ◽  
Xia Sun ◽  
Liying Lu ◽  
Han Gao ◽  
...  
Keyword(s):  
Stem Cell ◽  
Cross Talk ◽  
Intestinal Inflammation ◽  
Intestinal Stem Cells ◽  
Intestinal Stem Cell ◽  
Epithelial Barrier ◽  
Self Renewal ◽  
Epithelial Repair ◽  
Inflammatory Bowel

AbstractThe mucosa microenvironment is critical for intestinal stem cell self-renewal and reconstruction of the epithelial barrier in inflammatory bowel disease (IBD), where the mechanisms underlying cross-talk between intestinal crypts and the microenvironment remain unclear. Here, we firstly identified miR-494-3p as an important protector in colitis. miR-494-3p levels were decreased and negatively correlated with the severity in human IBD samples, as well as in colitis mice. In colitis crypts, a notable cytokine–cytokine receptor, miR-494-3p-targeted EDA2R and the ligand EDA-A2, suppressed colonic stemness and epithelial repair by inhibiting β-catenin/c-Myc. In differentiated IECs, miR-494-3p inhibits macrophage recruitment, M1 activation and EDA-A2 secretion by targeting IKKβ/NF-κB in colitis. A miR-494-3p agomir system notably ameliorated the severity of colonic colitis in vivo. Collectively, our findings uncover a miR-494-3p-mediated cross-talk mechanism by which macrophage-induced intestinal stem cell impairment aggravates intestinal inflammation.

scholarly journals Effects of bone morphogenetic proteins on epithelial repair

2021 ◽  
pp. 153537022110281
Author(s):  
Yu Hou ◽  
Yu-Xi He ◽  
Jia-Hao Zhang ◽  
Shu-Rong Wang ◽  
Yan Zhang
Keyword(s):  
Growth Factors ◽  
Epithelial Cells ◽  
Bone Morphogenetic Proteins ◽  
Epithelial Tissue ◽  
Epithelial Repair ◽  
Multiple Functions ◽  
Epithelial Damage ◽  
Damage Repair ◽  
And Migration ◽  
Proliferation And Migration

Epithelial tissue has important functions such as protection, secretion, and sensation. Epithelial damage is involved in various pathological processes. Bone morphogenetic proteins (BMPs) are a class of growth factors with multiple functions. They play important roles in epithelial cells, including in differentiation, proliferation, and migration during the repair of the epithelium. This article reviews the functions and mechanisms of the most profoundly studied BMPs in the process of epithelial damage repair and their clinical significance.

scholarly journals Fluid supplementation accelerates epithelial repair during chemical colitis

PLoS ONE ◽  
2019 ◽  
Vol 14 (4) ◽  
pp. e0215387 ◽  
Author(s):  
Juan F. Burgueño ◽  
Jessica K. Lang ◽  
Ana M. Santander ◽  
Irina Fernández ◽  
Ester Fernández ◽  
...  
Keyword(s):  
Epithelial Repair ◽  
Fluid Supplementation ◽  
Chemical Colitis

scholarly journals Macrophages promote epithelial repair through hepatocyte growth factor secretion

2013 ◽  
Vol 174 (1) ◽  
pp. 60-72 ◽  
Author(s):  
F. D'Angelo ◽  
E. Bernasconi ◽  
M. Schäfer ◽  
M. Moyat ◽  
P. Michetti ◽  
...  
Keyword(s):  
Growth Factor ◽  
Hepatocyte Growth Factor ◽  
Epithelial Repair ◽  
Hepatocyte Growth ◽  
Factor Secretion ◽  
Growth Factor Secretion

Growth factors accelerate epithelial repair in sheep trachea

Lung ◽  
1993 ◽  
Vol 171 (6) ◽  
pp. 335-344 ◽  
Author(s):  
Robert E. Barrow ◽  
Cheng-Z Wang ◽  
Michael J. Evans ◽  
David N. Herndon
Keyword(s):  
Growth Factors ◽  
Epithelial Repair

scholarly journals Airway epithelial repair in health and disease: Orchestrator or simply a player?

Respirology ◽  
2016 ◽  
Vol 21 (3) ◽  
pp. 438-448 ◽  
Author(s):  
Thomas Iosifidis ◽  
Luke W. Garratt ◽  
Deirdre R. Coombe ◽  
Darryl A. Knight ◽  
Stephen M. Stick ◽  
...  
Keyword(s):  
Airway Epithelial ◽  
Epithelial Repair ◽  
Health And Disease

scholarly journals Brief Report: Dclk1 Deletion in Tuft Cells Results in Impaired Epithelial Repair After Radiation Injury

Stem Cells ◽  
2014 ◽  
Vol 32 (3) ◽  
pp. 822-827 ◽  
Author(s):  
Randal May ◽  
Dongfeng Qu ◽  
Nathaniel Weygant ◽  
Parthasarathy Chandrakesan ◽  
Naushad Ali ◽  
...  
Keyword(s):  
Radiation Injury ◽  
Epithelial Repair ◽  
Tuft Cells
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