Family history of psychiatric disorders and the outcome of psychiatric patients with DSM-IV major depressive disorder

BackgroundIt has been suggested that offspring of parents with bipolar disorder are at increased risk for disruptive mood dysregulation disorder (DMDD), but the specificity of this association has not been established.AimsWe examined the specificity of DMDD to family history by comparing offspring of parents with (a) bipolar disorder, (b) major depressive disorder and (c) a control group with no mood disorders.MethodWe established lifetime diagnosis of DMDD using the Schedule for Affective Disorders and Schizophrenia for School Aged Children for DSM-5 in 180 youth aged 6–18 years, including 58 offspring of parents with bipolar disorder, 82 offspring of parents with major depressive disorder and 40 control offspring.ResultsDiagnostic criteria for DMDD were met in none of the offspring of parents with bipolar disorder, 6 of the offspring of parents with major depressive disorder and none of the control offspring. DMDD diagnosis was significantly associated with family history of major depressive disorder.ConclusionsOur results suggest that DMDD is not specifically associated with a family history of bipolar disorder and may be associated with parental depression.

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Joint Effect of Childhood Abuse and Family History of Major Depressive Disorder on Rates of PTSD in People with Personality Disorders

Depression Research and Treatment ◽

10.1155/2012/350461 ◽

2012 ◽

Vol 2012 ◽

pp. 1-7 ◽

Cited By ~ 2

Author(s):

Janine D. Flory ◽

Rachel Yehuda ◽

Vincent Passarelli ◽

Larry J. Siever

Keyword(s):

Major Depressive Disorder ◽

Family History ◽

Depressive Disorder ◽

Childhood Abuse ◽

Childhood Maltreatment ◽

Reference Group ◽

Joint Effect ◽

Major Depressive ◽

Increased Risk ◽

History Of

Objective. Childhood maltreatment and familial psychopathology both lead to an increased risk of the development of posttraumatic stress disorder (PTSD) in adulthood. While family history of psychopathology has traditionally been viewed as a proxy for genetic predisposition, such pathology can also contribute to a stress-laden environment for the child.Method. Analyses were conducted to evaluate the joint effect of childhood abuse and a family history of major depressive disorder (MDD) on diagnoses of PTSD and MDD in a sample of 225 adults with DSM-IV Axis II disorders.Results.Results showed that the rate of PTSD in the presence of both childhood abuse and MDD family history was almost six-fold (OR=5.89, P=.001) higher relative to the absence of both factors. In contrast, the rate of MDD in the presence of both factors was associated with a nearly three-fold risk relative to the reference group (OR=2.75, P=.01).Conclusions. The results from this observational study contribute to a growing understanding of predisposing factors for the development of PTSD and suggest that joint effects of family history of MDD and childhood abuse on PTSD are greater than either factor alone.

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Family History of DSM-III-R Dramatic Personality Disorder Cluster and Functioning in Patients with Major Depressive Disorder

The Journal of Nervous and Mental Disease ◽

10.1097/00005053-199509000-00005 ◽

1995 ◽

Vol 183 (9) ◽

pp. 587-592 ◽

Cited By ~ 1

Author(s):

JAMES REICH

Keyword(s):

Major Depressive Disorder ◽

Family History ◽

Personality Disorder ◽

Depressive Disorder ◽

Major Depressive ◽

History Of

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Major depressive disorder and family history of alcoholism in two treatment samples: Does gender matter?

Drug and Alcohol Dependence ◽

10.1016/j.drugalcdep.2016.08.459 ◽

2017 ◽

Vol 171 ◽

pp. e167

Author(s):

Kathryn McKenzie Polak ◽

Alexis Edwards ◽

Kenneth S. Kendler ◽

Dace Svikis ◽

Enkelejda Ngjelina ◽

...

Keyword(s):

Major Depressive Disorder ◽

Family History ◽

Depressive Disorder ◽

Major Depressive ◽

History Of

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Characteristics of major depressive disorder according to family history of depression : A CRESCEND-K (Clinical Research Center for Depression in Korea) study.

Korean Journal of Epidemiology ◽

10.4178/kje.2008.30.2.272 ◽

2008 ◽

Vol 30 (2) ◽

pp. 272-280 ◽

Cited By ~ 1

Author(s):

Seunghee Jeong ◽

Hyeon Woo Yim ◽

Youngeun Jung ◽

Sunjin Jo ◽

Taeyoun Jun ◽

...

Keyword(s):

Major Depressive Disorder ◽

Family History ◽

Depressive Disorder ◽

Clinical Research ◽

Research Center ◽

Major Depressive ◽

Clinical Research Center ◽

History Of ◽

Family History Of Depression ◽

History Of Depression

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Lymphocyte subsets and their association with the severity of patients with major depressive disorder (mdd)

International Journal of Human and Health Sciences (IJHHS) ◽

10.31344/ijhhs.v3i2.81 ◽

2019 ◽

Vol 3 (2) ◽

pp. 80

Author(s):

Noor Suryani Mohd Ashari ◽

Siti Nor Fairus Mohamed Sanusi ◽

Mohd Azhar Mohd Yasin ◽

Rohimah Mohamud ◽

Che Maraina Che Hussin

Keyword(s):

Major Depressive Disorder ◽

Family History ◽

Depressive Disorder ◽

Rural Area ◽

Healthy Controls ◽

Major Depressive ◽

Chi Square ◽

History Of ◽

Family History Of Depression ◽

History Of Depression

Introduction: Major Depressive Disorder (MDD) isexpected to become the second leading cause of worldwide disability by the year 2020 and the major contributor to the overall global burden of disease.Objective: This study was done to compare sociodemographicpredisposingfactors in MDD patients and controls in Kelantan, Malaysia.Methods: A total of 47 MDD patients and 47 healthy controls participated in this study. MDD patients were recruited from Psychiatric Clinic, HUSM and they were diagnosed according to DSM-V criteria. Patients’ biodata, medical and psychiatric history were taken by physician. Data were analysed using Pearson Chi-square and multiple logistic regression.Results: In MDD group, 61.7% were females and 38.3% were males. Forty two percent of MDD were in the age group of 45 to 65 years old and almost 12.8% of MDD patients had family history of depression, while all healthy controls were in good general health and had no family history of depression. Pearson Chi-square revealed that there were significant associations between smoking status (P=0.027), marital status (P=0.007) educational level (P=0.022) and area of living (P=0.0.036) with MDD. The results showed that unmarried person were less likely to have MDD compared to those married with adjusted odds ratio (OR) of 0.31. Smoker were 5.16 at odds of having MDD as compared to non-smoker, while individuals with a low education were more likely to have MDD compared to those highly educated with adjusted OR of 2.04. The result also showed those living in urban area were less likely to have MDD compared to those living in rural area with adjusted OR of 0.48.Conclusion: Higher age, female and positive family history possess a higher tendency of having MDD. In addition, smokers, married, less educated and living in rural area were more likely to have MDD compared to healthy controls.International Journal of Human and Health Sciences Vol. 03 No. 02 April’19. Page: 80-87

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Associations of current and remitted major depressive disorder with brain atrophy: the AGES–Reykjavik Study

Psychological Medicine ◽

10.1017/s0033291712001110 ◽

2012 ◽

Vol 43 (2) ◽

pp. 317-328 ◽

Cited By ~ 20

Author(s):

M. I. Geerlings ◽

S. Sigurdsson ◽

G. Eiriksdottir ◽

M. E. Garcia ◽

T. B. Harris ◽

...

Keyword(s):

Major Depressive Disorder ◽

White Matter ◽

Depressive Disorder ◽

Brain Atrophy ◽

Older Persons ◽

Age At Onset ◽

Prior History ◽

Major Depressive ◽

History Of ◽

Dsm Iv

BackgroundTo examine whether lifetime DSM-IV diagnosis of major depressive disorder (MDD), including age at onset and number of episodes, is associated with brain atrophy in older persons without dementia.MethodWithin the population-based Age, Gene/Environment Susceptibility (AGES)–Reykjavik Study, 4354 persons (mean age 76 ± 5 years, 58% women) without dementia had a 1.5-T brain magnetic resonance imaging (MRI) scan. Automated brain segmentation total and regional brain volumes were calculated. History of MDD, including age at onset and number of episodes, and MDD in the past 2 weeks was diagnosed according to DSM-IV criteria using the Mini-International Neuropsychiatric Interview (MINI).ResultsOf the total sample, 4.5% reported a lifetime history of MDD; 1.5% had a current diagnosis of MDD (including 75% with a prior history of depression) and 3.0% had a past but no current diagnosis (remission). After adjusting for multiple covariates, compared to participants never depressed, those with current MDD (irrespective of past) had more global brain atrophy [B = –1.25%, 95% confidence interval (CI) −2.05 to −0.44], including more gray- and white-matter atrophy in most lobes, and also more atrophy of the hippocampus and thalamus. Participants with current, first-onset MDD also had more brain atrophy (B = –1.62%, 95% CI −3.30 to 0.05) whereas those remitted did not (B = 0.06%, 95% CI −0.54 to 0.66).ConclusionsIn older persons without dementia, current MDD, irrespective of prior history, but not remitted MDD was associated with widespread gray- and white-matter brain atrophy. Prospective studies should examine whether MDD is a consequence of, or contributes to, brain volume loss and development of dementia.

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