Relationships Among History of Psychosis, Cognition and Functioning in Later-Life Remitted Major Depression

Background: Cumulative exposure to high glucocorticoid levels is detrimental for the brain and may have particular implications in later life. A feature of late-life depression is increased cortisol secretion. Variants in the CYP11B1 gene, which codes for the enzyme responsible for cortisol synthesis, could influence risk of late-life depression, but this hypothesis has not been examined. We investigated the associations between variants in the CYP11B1 gene and late-life depression, taking into account history of depression and potential sexspecific effects. Methods: We assessed depression in 1007 community-dwellers aged 65 years or older (60% women) at baseline and over a 14-year follow-up. A clinical level of depression was defined as a score of ≥ 16 on the Centre for Epidemiology Studies Depression scale or a diagnosis of current major depression based on the Mini-International Neuropsychiatric Interview and according to the criteria of the Diagnostic and Statistical Manual of Mental Disorders, 4th edition (DSM-IV). We examined incident and recurrent depression in participants without or with a history of major depression, respectively. We genotyped 5 single-nucleotide polymorphisms (SNPs) spanning CYP11B1. We used multivariable analyses to adjust for age, body mass index, cardiovascular ischemic pathologies, hypertension, cognitive impairment and anxiety. Results: In women, rs6471580 and rs7016924 were associated with a 50% lower rate of incident (new-onset) late-life depression, and rs11783855 was associated with a 2.4-fold higher rate of late-life depression. These associations remained after correction for multiple testing, but we found no associations for recurrent depression in women or men. Limitations: This study focused on the major gene involved in corticosteroid biosynthesis, but other genes may also be implicated in this pathway. Conclusion: Variants of the CYP11B1 gene appear to be susceptibility factors for late-life depression in a sex-specific manner.

Download Full-text

THE ASSOCIATIONS AMONG HISTORY OF PSYCHOSIS, NEUROPSYCHOLOGICAL PERFORMANCE, AND FUNCTIONING IN REMITTED LATER-LIFE MAJOR DEPRESSION

American Journal of Geriatric Psychiatry ◽

10.1016/j.jagp.2019.01.022 ◽

2019 ◽

Vol 27 (3) ◽

pp. S117-S118

Author(s):

Kathleen Bingham ◽

Deirdre Dawson ◽

Benoit Mulsant ◽

Samprit Banerjee ◽

Alastair Flint

Keyword(s):

Major Depression ◽

Later Life ◽

Neuropsychological Performance ◽

History Of

Download Full-text

Faculty Opinions recommendation of Fluoxetine, smoking, and history of major depression: A randomized controlled trial.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1067061.520044 ◽

2007 ◽

Author(s):

Lirio Covey

Keyword(s):

Randomized Controlled Trial ◽

Major Depression ◽

Controlled Trial ◽

Randomized Controlled ◽

History Of

Download Full-text

Clinical characteristics and sociodemographic features of psychotic major depression

Annals of General Psychiatry ◽

10.1186/s12991-021-00341-7 ◽

2021 ◽

Vol 20 (1) ◽

Author(s):

Meng-qi Wang ◽

Ran-ran Wang ◽

Yu Hao ◽

Wei-feng Xiong ◽

Ling Han ◽

...

Keyword(s):

Family History ◽

Major Depression ◽

Clinical Characteristics ◽

Missing Values ◽

Psychotic Disorders ◽

Mental Health Center ◽

Psychiatric Diseases ◽

First Onset ◽

History Of ◽

Psychotic Major Depression

Abstract Background Psychotic major depression (PMD) is a subtype of depression with a poor prognosis. Previous studies have failed to find many differences between patients with PMD and those with non-psychotic major depression (NMD) or schizophrenia (SZ). We compared sociodemographic factors (including season of conception) and clinical characteristics between patients with PMD, NMD, and schizophrenia. Our aim was to provide data to help inform clinical diagnoses and future etiology research. Methods This study used data of all patients admitted to Shandong Mental Health Center from June 1, 2016 to December 31, 2017. We analyzed cases who had experienced an episode of PMD (International Classification of Diseases, Tenth Revision codes F32.3, F33.3), NMD (F32.0–2/9, F33.0–2/9), and SZ (F20–20.9). Data on sex, main discharge diagnosis, date of birth, ethnicity, family history of psychiatric diseases, marital status, age at first onset, education, allergy history, and presence of trigger events were collected. Odds ratios (OR) were calculated using logistic regression analyses. Missing values were filled using the k-nearest neighbor method. Results PMD patients were more likely to have a family history of psychiatric diseases in their first-, second-, and third-degree relatives ([OR] 1.701, 95% confidence interval [CI] 1.019–2.804) and to have obtained a higher level of education (OR 1.451, 95% CI 1.168–1.808) compared with depression patients without psychotic features. Compared to PMD patients, schizophrenia patients had lower education (OR 0.604, 95% CI 0.492–0.741), were more often divorced (OR 3.087, 95% CI 1.168–10.096), had a younger age of onset (OR 0.934, 95% CI 0.914–0.954), less likely to have a history of allergies (OR 0.604, 95% CI 0.492–0.741), and less likely to have experienced a trigger event 1 year before first onset (OR 0.420, 95% CI 0.267–0.661). Season of conception, ethnicity, and sex did not differ significantly between PMD and NMD or schizophrenia and PMD. Conclusions PMD patients have more similarities with NMD patients than SZ patients in terms of demographic and clinical characteristics. The differences found between PMD and SZ, and PMD and NMD correlated with specificity of the diseases. Furthermore, allergy history should be considered in future epidemiological studies of psychotic disorders.

Download Full-text

Polygenic risk for major depression is associated with lifetime suicide attempt in US soldiers independent of personal and parental history of major depression

American Journal of Medical Genetics Part B Neuropsychiatric Genetics ◽

10.1002/ajmg.b.32868 ◽

2021 ◽

Author(s):

Murray B. Stein ◽

Sonia Jain ◽

Laura Campbell‐Sills ◽

Erin B. Ware ◽

Karmel W. Choi ◽

...

Keyword(s):

Major Depression ◽

Suicide Attempt ◽

Parental History ◽

Polygenic Risk ◽

History Of

Download Full-text

Neuropsychological deficits in past suicide attempters with varying levels of depression severity

Psychological Medicine ◽

10.1017/s0033291714000786 ◽

2014 ◽

Vol 44 (14) ◽

pp. 2965-2974 ◽

Cited By ~ 34

Author(s):

J. G. Keilp ◽

S. R. Beers ◽

A. K. Burke ◽

N. M. Melhem ◽

M. A. Oquendo ◽

...

Keyword(s):

Working Memory ◽

Major Depression ◽

Rating Scale ◽

Suicide Attempts ◽

Past History ◽

Clinical State ◽

Suicide Attempters ◽

History Of ◽

Attention Memory ◽

Interference Processing

BackgroundOur previous work identified deficits in interference processing and learning/memory in past suicide attempters who were currently depressed and medication-free. In this study, we extend this work to an independent sample studied at various stages of illness and treatment (mild symptoms, on average) to determine if these deficits in past suicide attempters are evident during a less severe clinical state.MethodA total of 80 individuals with a past history of major depression and suicide attempt were compared with 81 individuals with a history of major depression and no lifetime suicide attempts on a battery of neurocognitive measures assessing attention, memory, abstract/contingent learning, working memory, language fluency and impulse control.ResultsPast attempters performed more poorly in attention, memory and working memory domains, but also in an estimate of pre-morbid intelligence. After correction for this estimate, tests that had previously distinguished past attempters – a computerized Stroop task and the Buschke Selective Reminding Test – remained significantly worse in attempters. In a secondary analysis, similar differences were found among those with the lowest levels of depression (Hamilton Depression Rating Scale score <10), suggesting that these deficits may be trait markers independent of current symptomatology.ConclusionsDeficits in interference processing and learning/memory constitute an enduring defect in information processing that may contribute to poor adaptation, other higher-order cognitive impairments and risk for suicidal behavior.

Download Full-text

Anorexia Nervosa and Depression in a Woman Blind since the Age of Nine Months

The Canadian Journal of Psychiatry ◽

10.1177/070674379303800701 ◽

1993 ◽

Vol 38 (7) ◽

pp. 469-471 ◽

Cited By ~ 11

Author(s):

Clifford W. Sharp

Keyword(s):

Eating Disorders ◽

Body Image ◽

Anorexia Nervosa ◽

Eating Disorder ◽

Major Depression ◽

Food Intake ◽

Older Women ◽

The Body ◽

Atypical Presentation ◽

History Of

A woman aged 58 who has been blind since the age of nine months presented with major depression and a 40 year history of an eating disorder characterized by a restriction of food intake and body disparagement. The case is additional evidence that a specifically visual body image is not essential for the development of anorexia nervosa and supports the view that the concept of body image is unnecessary and unproductive in eating disorders. Greater emphasis should be placed on attitudes and feelings toward the body, and the possibility of an eating disorder should be considered in cases of older women with an atypical presentation.

Download Full-text