Clinical characteristics and sociodemographic features of psychotic major depression

Abstract Background Psychotic major depression (PMD) is a subtype of depression with a poor prognosis. Previous studies have failed to find many differences between patients with PMD and those with non-psychotic major depression (NMD) or schizophrenia (SZ). We compared sociodemographic factors (including season of conception) and clinical characteristics between patients with PMD, NMD, and schizophrenia. Our aim was to provide data to help inform clinical diagnoses and future etiology research. Methods This study used data of all patients admitted to Shandong Mental Health Center from June 1, 2016 to December 31, 2017. We analyzed cases who had experienced an episode of PMD (International Classification of Diseases, Tenth Revision codes F32.3, F33.3), NMD (F32.0–2/9, F33.0–2/9), and SZ (F20–20.9). Data on sex, main discharge diagnosis, date of birth, ethnicity, family history of psychiatric diseases, marital status, age at first onset, education, allergy history, and presence of trigger events were collected. Odds ratios (OR) were calculated using logistic regression analyses. Missing values were filled using the k-nearest neighbor method. Results PMD patients were more likely to have a family history of psychiatric diseases in their first-, second-, and third-degree relatives ([OR] 1.701, 95% confidence interval [CI] 1.019–2.804) and to have obtained a higher level of education (OR 1.451, 95% CI 1.168–1.808) compared with depression patients without psychotic features. Compared to PMD patients, schizophrenia patients had lower education (OR 0.604, 95% CI 0.492–0.741), were more often divorced (OR 3.087, 95% CI 1.168–10.096), had a younger age of onset (OR 0.934, 95% CI 0.914–0.954), less likely to have a history of allergies (OR 0.604, 95% CI 0.492–0.741), and less likely to have experienced a trigger event 1 year before first onset (OR 0.420, 95% CI 0.267–0.661). Season of conception, ethnicity, and sex did not differ significantly between PMD and NMD or schizophrenia and PMD. Conclusions PMD patients have more similarities with NMD patients than SZ patients in terms of demographic and clinical characteristics. The differences found between PMD and SZ, and PMD and NMD correlated with specificity of the diseases. Furthermore, allergy history should be considered in future epidemiological studies of psychotic disorders.

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Clinical characteristics and socio-demographic features of psychotic major depression

10.21203/rs.3.rs-32003/v1 ◽

2020 ◽

Author(s):

Mengqi Wang ◽

Ranran Wang ◽

Yu Hao ◽

Weifeng Xiong ◽

Dongdong Qiao ◽

...

Keyword(s):

Family History ◽

Major Depression ◽

Primary School ◽

Clinical Characteristics ◽

Mental Health Center ◽

Psychotic Symptoms ◽

Birth Date ◽

First Onset ◽

Psychotic Major Depression ◽

Trigger Events

Abstract Background Psychotic major depression (PMD) is a special subtype of depression with a worse prognosis. Previous studies failed to find many differences among patients with PMD versus those with non-psychotic major depression (NMD) or schizophrenia(SZ). This study compared psychotic major depression with non-psychotic major depression and schizophrenia based on sociodemographic factors (including season of conception) and clinical characteristics. We aimed to provide data to inform clinical diagnoses and etiology research. Methods This case–control study used data for patients admitted to Shandong Mental Health Center from June 1, 2016 to December 31, 2017. We analyzed cases that had experienced a PMD episode (International Classification of Diseases, Tenth Revision codes F32.3, F33.3), NMD (F32.0–2/9, F33.0–2/9), and SZ (F20–20.9). Data were collected on sex, main discharge diagnosis, birth date, ethnicity, family history of psychiatric diagnoses, marital status, age at first onset, educational attainment, allergy history, and existence of trigger events. Results Patients with depression with a primary school/below education (odds ratio [OR] 0.397, CI: 0.18–0.874) and without a family history (OR 0.557, CI: 0.332–0.937) were less likely to have psychotic symptoms than other patients. Compared with patients with PMD, a primary school/below education (OR 3.646, CI: 1.65–8.053), no allergy history (OR 2.2, CI: 1.152–4.2), trigger events experienced before first onset (OR 2.428, CI: 1.528–3.859), being unmarried (OR 0.3, CI: 0.104–0.871), and an earlier age at first onset (OR 0.931, CI: 0.911–0.952) were features of SZ. Conclusion PMD and NMD are similar in terms of patients’ demographic variables and clinical characteristics, whereas there are differences between PMD and SZ. The significant factors we identified may point to underlying heterogeneity of these diseases.

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Family history of alcoholism and gender: their combined effects on DSM-IV alcohol dependence and major depression.

Journal of Studies on Alcohol ◽

10.15288/jsa.1998.59.97 ◽

1998 ◽

Vol 59 (1) ◽

pp. 97-106 ◽

Cited By ~ 62

Author(s):

D A Dawson ◽

B F Grant

Keyword(s):

Family History ◽

Major Depression ◽

Alcohol Dependence ◽

Combined Effects ◽

History Of ◽

Dsm Iv ◽

And Gender

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Patients with History of Myocardial Infarction and Acute Cerebrovascular Accidentin Clinical Practice: Demographic, Clinical Characteristics, Drug Treatment and Outcomes (Data of Outpatient and Hospital Registry REGION)

Rational Pharmacotherapy in Cardiology ◽

10.20996/1819-6446-2019-15-5-656-662 ◽

2019 ◽

Vol 15 (5) ◽

pp. 656-662 ◽

Cited By ~ 1

Author(s):

E. Yu. Okshina ◽

M. M. Loukianov ◽

S. Yu. Martsevich ◽

S. S. Yakushin ◽

N. P. Kutishenko ◽

...

Keyword(s):

Myocardial Infarction ◽

Clinical Practice ◽

Family History ◽

Drug Treatment ◽

Clinical Characteristics ◽

Beta Blockers ◽

All Cause Mortality ◽

History Of ◽

Hospital Registry

Aim. To assess the demographic and clinical characteristics, drug treatment and outcomes in patients with a history of acute cerebrovascular accident (ACVA) and with concomitant history of myocardial infarction (MI) in clinical practice based on outpatient and hospital parts of REGION registry.Material and methods. The total 1886 patients with a history of ACVA (aged of 70.6±12.5 years, 41.9% men) were enrolled into the outpatient registry REGION (Ryazan) and the hospital registry REGION (Moscow). 356 patients had ACVA and a history of MI (group “ACVA+MI” and 1530 patients had ACVA without history of MI (group “ACVA without MI”). The incidence of cardiovascular diseases (CVD), non-CVD comorbidities, drug therapy and outcomes were analyzed.Results. In the group ACVA+MI compared with group ACVA without MI the significantly higher proportions of patients with the following conditions (diagnosis) were revealed: arterial hypertension (AH) – 99.1% and 94.2%; coronary heart disease (CHD) – 100% and 57%; chronic heart failure (CHF) – 61.5% and 41.8%; atrial fibrillation (AF) – 42.7% and 23.8%; repeated ACVA – 32.9% and 18.9%, respectively, p<0.0001 for all. In ACVA+MI and ACVA without MI groups the respective proportions of patients were smokers – 16.2% and 23.7% (p=0.10), had a family history of premature CVD – 3.2% and 1.2% (p=0.01), and had a hypercholesterolemia – 47% and 59.7% (p<0.001). The incidence of drug administration with proved positive prognostic effect was insufficient in both groups, but higher in the ACVA+MI group compared with ACVA without MI group (on average 47.1% and 40%, respectively), including: anticoagulants in AF – 19.1% and 21.4% (p=0.55); antiplatelets in CHD without AF – 69.4% and 42% (p<0.001); statins in CHD – 26.4% and 17.2% (p<0.001); beta-blockers in CHF – 39% and 23.8% (p=0.002), respectively. During 4- year follow-up in the group ACVA+MI compared with group ACVA without MI there were significantly higher all-cause mortality – 44.9% and 26.8% (p<0.001), nonfatal recurrent ACVA – 13.7% and 5.6% (p=0.0001), and nonfatal MI – 6.9% and 1.0% (p<0.0001), respectively.Conclusion. The proportion of patients with a history of MI was 18.9% among the patients with a history of ACVA. In patients of ACVA+MI group, compared with patients of ACVA without MI group a higher incidence of the following characteristics was revealed: a presence of AH, CHD, CHF, AF, repeated ACVA and a family history of premature CVD. The incidence of taking drug with proved positive effect on prognosis in patients of the compared groups was insufficient, especially of statins and anticoagulants in AF. During the follow-up period ACVA+MI group was characterized by a higher all-cause mortality and higher incidence of nonfatal ACVA and MI. In these patients the improvement of the quality of pharmacotherapy and of the secondary prevention effectiveness are the measures of especial importance.

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Short-Lasting Headaches in Children

Cephalalgia ◽

10.1111/j.1468-2982.2006.01205.x ◽

2006 ◽

Vol 26 (10) ◽

pp. 1220-1224 ◽

Cited By ~ 20

Author(s):

JP Vieira ◽

AB Salgueiro ◽

M Alfaro

Keyword(s):

Family History ◽

Clinical Characteristics ◽

Paroxysmal Hemicrania ◽

Primary Headaches ◽

Secondary Headache ◽

Younger Age ◽

Associated Symptoms ◽

History Of ◽

Stabbing Headache ◽

Idiopathic Stabbing Headache

Short-lasting headaches have been studied infrequently in children and it is not known if the main categories of primary headaches of this type in adults are applicable to children. We report our experience with a group of 20 children with a brief headache. Two patients had a secondary headache. One patient had a headache with some clinical characteristics of paroxysmal hemicrania. The remaining 17 had a very brief headache. They were in many aspects comparable to others from previous studies on idiopathic stabbing headache in children: no associated symptoms, no other associated headache, frequent family history of migraine. They differed, however, in the younger age of the patients and the more frequent extratrigeminal location of the pain. Extratrigeminal ice-pick pain may be a variant of idiopathic stabbing headache, more prevalent in young children.

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A Case Report of Non-Reactive Psychosis in a COVID-19 Patient

RECENT ADVANCES IN PATHOLOGY AND LABORATORY MEDICINE ◽

10.24321/2454.8642.202104 ◽

2021 ◽

Vol 7 (1&2) ◽

pp. 11-13

Author(s):

Manjulika Debnath ◽

Keyword(s):

Family History ◽

Clinical Presentation ◽

Psychiatric Symptoms ◽

Past History ◽

Psychotic Symptoms ◽

Antigen Test ◽

First Onset ◽

History Of ◽

Coronavirus Infection ◽

Anxiety Depression

Background: COVID-19 causes reactive psychiatric symptoms like anxiety, depression, insomnia etc besides significant inflammatory response. A number of COVID-19 patients are found to present with complex neuropsychiatric syndromes, including the first onset of psychosis, that seem to be directly related to brain damage in the context of COVID-19. Most cases of psychotic disorder in COVID-19 patients are being found in individuals with no personal or family history of mental illness. Case Description: A 33-year-old man presented with acute restlessness, agitation, wandering, vandalizing things, suspiciousness, hallucinatory behaviour, decreased sleep for 3 days duration. There was no past history or family history of any psychiatric illness. There was a history of mild grade fever 7 days before the onset of the psychotic symptoms. The patient was uncooperative, irritable, and had hallucinatory behaviour. Rapid Antigen Test (RAT) was positive. The patient responded to injectable antipsychotic haloperidol which was later changed to Tab Olanzepine 5 mg. The patient developed no COVID symptoms and no psychotic symptoms were seen further. Conclusion: There is a possibility of a psychosis break as a COVID-19 clinical presentation, suggesting potential participation of inflammatory and autoimmunologic phenomena triggered as a response to the coronavirus infection.

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MODY2 in Asia: analysis of GCK mutations and clinical characteristics

Endocrine Connections ◽

10.1530/ec-20-0074 ◽

2020 ◽

Vol 9 (5) ◽

pp. 471-478

Author(s):

Yuan Zhou ◽

ShengNan Wang ◽

Jing Wu ◽

JianJun Dong ◽

Lin Liao

Keyword(s):

Family History ◽

Clinical Characteristics ◽

Correct Diagnosis ◽

Molecular Genetic ◽

Maturity Onset Diabetes ◽

Coding Regions ◽

Asian Patients ◽

Onset Diabetes ◽

Common Location ◽

History Of

Aims Heterozygous inactivating mutations in the GCK gene cause the familial, mild fasting hyperglycaemia named MODY2. Many patients with MODY2 in Asia have delayed timely treatment because they did not receive the correct diagnosis. This study aims to analyze the clinical characteristics and GCK mutations in Asian MODY2. Methods We have collected 110 Asian patients with MODY2 from the PubMed, Embase, Medline, Web of Science, CNKI, and Wanfang with the following search terms: ‘maturity-onset diabetes of the young’ OR ‘MODY’ OR ‘maturity-onset diabetes of the young type 2’ OR ‘MODY2’ OR ‘GCK-DM’ OR ‘GCK-MODY’. Both mutations of GCK and clinical characteristics of MODY2 were analyzed. Results There were 96 different mutations that occurred in coding regions and non-coding regions. Exon 5 and 7 were the most common location in coding regions and missense was the primary mutation type. The proportion of probands younger than 25 was 81.8%, and 81.4% of the probands had family history of hyperglycaemia. Ninety percent and 93% of Asian MODY2 probands exhibited mild elevation in FPG (5.4–8.3 mmol/L) and HbA1c (5.6–7.6%), respectively. Conclusions In most Asian patients, MODY2 occurred due to GCK mutation in coding regions, and exon 5 and 7 were the most common locations. FPG, HbA1c, and familial diabetes were important reference indicators for diagnosing MODY2. Altogether, the study indicates that for the young onset of diabetes with mild elevated blood glucose and HbA1c and family history of hyperglycaemia, molecular genetic testing is suggested in order to differentiate MODY2 from other types of diabetes earlier.

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COVID-19 patients managed in psychiatric inpatient settings due to first-episode mental disorders in Wuhan, China: clinical characteristics, treatments, outcomes, and our experiences

Translational Psychiatry ◽

10.1038/s41398-020-01022-x ◽

2020 ◽

Vol 10 (1) ◽

Author(s):

Qin Xie ◽

Fang Fan ◽

Xue-Peng Fan ◽

Xiao-Jiang Wang ◽

Ming-Jian Chen ◽

...

Keyword(s):

Mental Disorders ◽

Clinical Characteristics ◽

Psychotic Disorders ◽

Psychiatric Inpatient ◽

Adjustment Disorder ◽

Mental Illnesses ◽

Control Group ◽

Clinical Diagnoses ◽

Inpatient Settings ◽

First Onset

Abstract Data are scarce regarding the comorbid mental disorders and their management among COVID-19 patients. This study described the clinical characteristics and management of COVID-19 patients treated in psychiatric inpatient settings due to comorbid first-onset mental disorders in Wuhan, China. This electronic medical records-based study included 25 COVID-19 patients with first-onset mental disorders and 55 patients with first-onset mental disorders without COVID-19 (control group). Data collected included ICD-10 diagnoses of mental disorders, psychiatric and respiratory symptoms, treatments, and outcomes. Adjustment disorder (n = 11, 44.0%) and acute and transient psychotic disorders, with associated acute stress (n = 6, 24.0%) were main clinical diagnoses in the COVID-19 group while serious mental illnesses (i.e., schizophrenia, 24.5%) and alcohol use disorders (10.9%) were overrepresented in the control group. On admission, the most common psychiatric symptom in COVID-19 patients was insomnia symptoms (n = 18, 72.0%), followed by aggressive behaviors (n = 16, 64.0%), delusion (n = 10, 40.0%), and severe anxiety (n = 9, 36.0%). In addition to respiratory treatments, 76.0% COVID-19 patients received antipsychotics, 40.0% sedative-hypnotics, and 24.0% mood stabilizers. At the end of inpatient treatment, 4 (16.0%) COVID-19 patients were transferred to other hospitals to continue respiratory treatment after their psychiatric symptoms were controlled while the remaining 21 (84.0%) all recovered. Compared to the control group, COVID-19 group had significantly shorter length of hospital stay (21.2 vs. 37.4 days, P < 0.001). Adjustment disorder and acute and transient psychotic disorders are the main clinical diagnoses of COVID-19 patients managed in psychiatric inpatient settings. The short-term prognosis of these patients is good after conventional psychotropic treatment.

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Clinical Characteristics of Type 2 Diabetes Patients according to Family History of Diabetes

Korean Diabetes Journal ◽

10.4093/kdj.2010.34.4.222 ◽

2010 ◽

Vol 34 (4) ◽

pp. 222 ◽

Cited By ~ 5

Author(s):

Seung Uk Jeong ◽

Dong Gu Kang ◽

Dae Ho Lee ◽

Kang Woo Lee ◽

Dong-Mee Lim ◽

...

Keyword(s):

Type 2 Diabetes ◽

Family History ◽

Clinical Characteristics ◽

Family History Of Diabetes ◽

History Of ◽

Diabetes Patients

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Family history of diabetes is associated with diabetic foot complications in type 2 diabetes

Scientific Reports ◽

10.1038/s41598-020-74071-3 ◽

2020 ◽

Vol 10 (1) ◽

Author(s):

Xiao-fen Xiong ◽

Ling Wei ◽

Ying Xiao ◽

Ya-Chun Han ◽

Jinfei Yang ◽

...

Keyword(s):

Type 2 Diabetes ◽

Family History ◽

Multiple Regression ◽

Diabetic Foot ◽

Clinical Characteristics ◽

Family Members ◽

Family History Of Diabetes ◽

Foot Complications ◽

History Of

Abstract To investigate the relationship between diabetic foot complications (DFCs) and clinical characteristics, especially the number and types of first-degree family members with diabetes. A total of 8909 type 2 diabetes patients were enrolled. The clinical characteristics of these patients, including DFCs and family history of diabetes (FHD), were collected from medical records. Multiple regression was used to investigate the association between FHD and DFCs after adjusting for confounding factors. The patients with one and more than one first-degree family member with diabetes accounted for 18.7% and 12.8%, respectively. The proportions of the participants with a father with diabetes, a mother with diabetes, both parents with diabetes, siblings with diabetes, father and siblings with diabetes, mother and siblings with diabetes, and both parents and siblings with diabetes were 3.5%, 6.2%, 1.1%, 14.4%, 1.5%, 4%, and 0.7%, respectively. The multiple regression analysis showed that the number of family members with diabetes was positively associated with DFCs. However, among the different types of FHD, only the patients with a mother with diabetes showed a statistical association with DFCs. In addition to FHD, other factors, including gender, body mass index, platelet count, hemoglobin levels, albumin levels, high-density cholesterol levels, diabetic peripheral neuropathy, and the use of lipid-lowering agents, oral hypoglycemic agents, and insulin, were also associated with DFCs. DFCs were associated with different numbers of family members with diabetes and types of FHD. This association reveals the importance of genetic and environmental factors in DFCs and highlights the importance of adding FHD to public health strategies targeting detecting and preventing the disease.

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