[O1-03-01]: IL-6 allelic variation and medial temporal morphology in MCI and older adults with memory complaints

2005 ◽  
Vol 1 ◽  
pp. S82-S83 ◽  
Author(s):  
Andrew J. Saykin ◽  
Heather A. Wishart ◽  
Tara L. McHugh ◽  
Laura A. Rabin ◽  
John D. West ◽  
...  
2017 ◽  
Vol 75 (4) ◽  
pp. 228-233 ◽  
Author(s):  
Rodrigo de Rosso Krug ◽  
Anna Quialheiro Abreu da Silva ◽  
Ione Jayce Ceola Schneider ◽  
Luiz Roberto Ramos ◽  
Eleonora d’Orsi ◽  
...  

ABSTRACT Objective To estimate the effect of participating in cognitive cooperation groups, mediated by computers and the internet, on the Mini-Mental State Examination (MMSE) percent variation of outpatients with memory complaints attending two memory clinics. Methods A prospective controlled intervention study carried out from 2006 to 2013 with 293 elders. The intervention group (n = 160) attended a cognitive cooperation group (20 sessions of 1.5 hours each). The control group (n = 133) received routine medical care. Outcome was the percent variation in the MMSE. Control variables included gender, age, marital status, schooling, hypertension, diabetes, dyslipidaemia, hypothyroidism, depression, vascular diseases, polymedication, use of benzodiazepines, exposure to tobacco, sedentary lifestyle, obesity and functional capacity. The final model was obtained by multivariate linear regression. Results The intervention group obtained an independent positive variation of 24.39% (CI 95% = 14.86/33.91) in the MMSE compared to the control group. Conclusion The results suggested that cognitive cooperation groups, mediated by computers and the internet, are associated with cognitive status improvement of older adults in memory clinics.


2018 ◽  
Vol 61 (3) ◽  
pp. 1089-1096 ◽  
Author(s):  
Prabha Siddarth ◽  
Berna Rahi ◽  
Natacha D. Emerson ◽  
Alison C. Burggren ◽  
Karen J. Miller ◽  
...  

2015 ◽  
Vol 11 (2) ◽  
pp. 238-251 ◽  
Author(s):  
Francesca Clerici ◽  
Roberta Ghiretti ◽  
Alessandra Di Pucchio ◽  
Simone Pomati ◽  
Valentina Cucumo ◽  
...  

2020 ◽  
pp. 1-8
Author(s):  
E. González-Bautista ◽  
P. de Souto Barreto ◽  
K. Virecoulon Giudici ◽  
S. Andrieu ◽  
Y. Rolland ◽  
...  

Background: The screening tool of the Integrated Care for Older People (ICOPE Step 1), designed to detect declines in the domains of intrinsic capacity, has been incipiently investigated in older adult populations. Objectives: To retrospectively estimate the frequency of priority conditions associated with declines in intrinsic capacity according to an adaptation of the screening tool ICOPE Step 1 among participants of the Multidomain Alzheimer Preventive Trial (MAPT). Design: A cross-sectional retrospective analysis from the baseline assessment of the MAPT. Setting: The data was gathered during a preventive consultation for cardiovascular risk factors in memory clinics in France. Participants : Seven hundred fifty-nine older adults aged 70-89 years with memory complaints, allocated to the multidomain groups of the MAPT study. Measurements: Five domains of intrinsic capacity (cognition, locomotion, nutrition, sensorial, and psychological) were assessed using a screening tool similar to the ICOPE Step 1 (MAPT Step 1). The frequency of six conditions associated with declines in intrinsic capacity (cognitive decline, limited mobility, malnutrition, visual impairment, hearing loss, and depressive symptoms) was obtained for older adults with memory complaints participating in the MAPT study. Results: Overall, 89.3% of the participants had one or more conditions associated with declines in intrinsic capacity. The overall frequency of each condition was: 52.2% for cognitive decline, 20.2% for limited mobility, 6.6% for malnutrition, 18.1% for visual impairment, 56.2% for hearing loss, and 39% for depressive symptoms. Conclusion: After being screened with an adaptation of the ICOPE step 1 (MAPT step 1) tool, 9/10 older adults had one or more conditions associated with declines in intrinsic capacity. The relative frequency differs across conditions and could probably be lower in a population without memory complaints. The frequency of screened conditions associated with declines in IC highlights how relevant it is to develop function-centered care modalities to promote healthy aging.


PLoS ONE ◽  
2021 ◽  
Vol 16 (5) ◽  
pp. e0252016
Author(s):  
Udhir Ramnath ◽  
Laurie Rauch ◽  
Estelle Victoria Lambert ◽  
Tracy Kolbe-Alexander

Purpose The effects of aging on physical and mental health may be ameliorated by regular participation in physical activity (PA). There is also evidence for the benefits of various training modalities on cognition and functional ability in older adults. The aim of this study was to compare effects of a 12-week active video gaming intervention (X Box Kinect Sports) to conventional multimodal supervised exercise on fitness, functional ability and cognitive performance in older adults with memory complaints. Methods Participants (n = 45, 72±5 yrs.) were recruited from 6 retirement homes and cluster-randomized into the Interactive Video Gaming (IVG) group (N = 23) or Conventional Multimodal (CM) group (N = 22), meeting 2 x 1 hour sessions, weekly for 12 weeks. Pre-post measures included: 6 min walk, timed up and go, dynamic balance, functional reach, Mini-Mental State Examination, N-back Task and the Modified Stroop task. Results The IVG group demonstrated significant improvement in the total number correct responses on the Stroop task (P = 0.028) and for average reaction time of correct colour-words (P = 0.024), compared to the CM group. Functional ability improved significantly in the IVG group, including the 6-min walk (P = 0.017), dynamic balance (P = 0.03), timed up and go (P<0.001) and functional reach (P<0.0010). Conclusion An active interactive video gaming intervention was more effective than conventional multimodal exercise in improving executive and global cognitive performance and functional capacity in older adults with subjective memory complaints. Trial registration Pan African Clinical Trial Registry—PACTR202008547335106.


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