P3-102: A new method for obtaining accurate estimates of measurement precision for neuropsychological test batteries too complex to be modeled with a single factor model: Memory in the Alzheimer's disease neuroimaging initiative (ADNI)

Abstract. We investigated theory of mind (ToM) deficits in Alzheimer‘s disease (AD) and its possible connection to autobiographical memory (ABM). Patients and matched controls were evaluated and compared using a video-based ToM test, an autobiographical fluency task, and a neuropsychological test battery. We found that ToM deficits were positively associated with semantic ABM in the clinical group, whereas a positive relationship appeared between ToM and episodic ABM in controls. We hypothesize that this reflects the course of the disease as well as that semantic ABM is used for ToM processing, being still accessible in AD. Furthermore, we assume that it is also less efficient, which in turn leads to a specific deficit profile of social cognition.

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Supplemental Material for Latent Structure and Factorial Invariance of a Neuropsychological Test Battery for the Study of Preclinical Alzheimer's Disease

Neuropsychology ◽

10.1037/a0020176.supp ◽

2010 ◽

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Neuropsychological Test ◽

Factorial Invariance ◽

Test Battery ◽

Latent Structure ◽

Preclinical Alzheimer’S Disease ◽

Neuropsychological Test Battery

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Cross-Cultural Evaluation of Antonovsky’s Orientation to Life Questionnaire: Comparison Between Australian, Finnish, and Turkish Young Adults

Psychological Reports ◽

10.1177/0033294118765420 ◽

2018 ◽

Vol 122 (2) ◽

pp. 731-747 ◽

Cited By ~ 1

Author(s):

Timo Lajunen

Keyword(s):

Cultural Differences ◽

Factor Model ◽

Well Being ◽

Cross Cultural ◽

Life Questionnaire ◽

Single Factor ◽

Scale Scores ◽

Health And Well Being ◽

Three Factor ◽

Single Factor Model

Antonovsky’s concept “sense of coherence” (SOC) and the related measurement instrument “The Orientation to Life Questionnaire” (OLQ) has been widely applied in studies on health and well-being. The purpose of the present study is to investigate the cultural differences in factor structures and psychometric properties as well as mean scores of the 13-item form of Antonovsky’s OLQ among Australian (n = 201), Finnish (n = 203), and Turkish (n = 152) students. Three models of factor structure were studied by using confirmatory factor analysis: single-factor model, first-order correlated-three-factor model, and the second-order three-factor model. Results obtained in all three countries suggest that the first- and second-order three-factor models fitted the data better that the single-factor model. Hence, the OLQ scoring based on comprehensibility, manageability, and meaningfulness scales was supported. Scale reliabilities and inter-correlations were in line with those reported in earlier studies. Two-way analyses of variance (gender × nationality) with age as a covariate showed no cultural differences in SOC scale scores. Women got higher scores on the meaningfulness scale than men, and age was positively related to all SOC scale scores indicating that SOC increases in early adulthood. The results support the three-factor model of OLQ which thus should be used in Australia, Finland, and Turkey instead of a single-factor model. Need for cross-cultural studies taking into account cultural correlates of SOC and its relation to health and well-being indicators as well as studies on gender differences in the OLQ are emphasized.

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Attention and inhibition in Mild Cognitive Impairment and Alzheimer's Disease

Escritos de Psicología / Psychological Writings ◽

10.24310/espsiescpsi.v6i3.13288 ◽

2013 ◽

Vol 6 (3) ◽

pp. 43-50

Author(s):

Clara Zancada-Menéndez ◽

Patricia Sampedro-Piquero ◽

Azucena Begega ◽

Laudino López ◽

Jorge Luis Arias

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Cognitive Impairment ◽

Mild Cognitive Impairment ◽

Reaction Time ◽

Alzheimer Disease ◽

Neuropsychological Test ◽

Reaction Times ◽

Stop Signal Task ◽

Healthy Controls

Mild cognitive impairment is understood as a cognitive deficit of insufficient severity to fulfil the criteria for Alzheimer’s disease. Many studies have attempted to identify which cognitive functions are most affected by this type of impairment and which is the most sensitive neuropsychological test for early detection. This study investigated sustained and selective attention, processing speed, and the inhibition process using a sample of people divided into three groups mild cognitive impairment, Alzheimer disease and cognitively healthy controls selected and grouped based on their scores in the Mini Mental State Examination and Cambridge Cognitive Examination-revised. Three tests from the Cambridge Neuropsychological Test Automated Battery (Motor Screening Task, Stop Signal Task and Reaction time) were used as well as the d2 attention test. The results show that that participants with mild cognitive impairment and Alzheimer disease showed lower levels of concentration compared with the cognitively healthy controls group in the d2 test and longer reaction times in the Cambridge Neuropsychological Test Automated Battery, although the differences were not marked in the latter test. The impairments in basic cognitive processes, such as reaction time and sustained attention, indicate the need to take these functions into account in the test protocols when discriminating between normal aging and early and preclinical dementia processes.

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Association and Gene–-Gene Interactions Study of Late-Onset Alzheimer’s Disease in the Russian Population

Genes ◽

10.3390/genes12101647 ◽

2021 ◽

Vol 12 (10) ◽

pp. 1647

Author(s):

Anna Bocharova ◽

Kseniya Vagaitseva ◽

Andrey Marusin ◽

Natalia Zhukova ◽

Irina Zhukova ◽

...

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Neurodegenerative Disorder ◽

Factor Model ◽

Late Onset ◽

Interaction Network ◽

Russian Population ◽

Protein Protein Interaction ◽

Protective Haplotype ◽

Single Snps

Alzheimer’s disease (AD) is a neurodegenerative disorder, and represents the most common cause of dementia. In this study, we performed several different analyses to detect loci involved in development of the late onset AD in the Russian population. DNA samples from 472 unrelated subjects were genotyped for 63 SNPs using iPLEX Assay and real-time PCR. We identified five genetic loci that were significantly associated with LOAD risk for the Russian population (TOMM40 rs2075650, APOE rs429358 and rs769449, NECTIN rs6857, APOE ε4). The results of the analysis based on comparison of the haplotype frequencies showed two risk haplotypes and one protective haplotype. The GMDR analysis demonstrated three significant models as a result: a one-factor, a two-factor and a three-factor model. A protein–protein interaction network with three subnetworks was formed for the 24 proteins. Eight proteins with a large number of interactions are identified: APOE, SORL1, APOC1, CD33, CLU, TOMM40, CNTNAP2 and CACNA1C. The present study confirms the importance of the APOE-TOMM40 locus as the main risk locus of development and progress of LOAD in the Russian population. Association analysis and bioinformatics approaches detected interactions both at the association level of single SNPs and at the level of genes and proteins.

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Value of Neuropsychological Tests to Identify Patients with Depressive Symptoms on the Alzheimer’s Disease Continuum

Journal of Alzheimer s Disease ◽

10.3233/jad-200710 ◽

2020 ◽

Vol 78 (2) ◽

pp. 819-826

Author(s):

Felix Menne ◽

Carola Gertrud Schipke ◽

Arne Klostermann ◽

Manuel Fuentes-Casañ ◽

Silka Dawn Freiesleben ◽

...

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Depressive Symptoms ◽

Neuropsychological Tests ◽

Neuropsychological Test ◽

Memory Task ◽

Geriatric Depression Scale ◽

Depression Scale ◽

Area Under The Curve ◽

Csf Biomarkers

Background: Depressive symptoms often co-occur with Alzheimer’s disease (AD) and can impact neuropsychological test results. In early stages of AD, disentangling cognitive impairments due to depression from those due to neurodegeneration often poses a challenge. Objective: We aimed to identify neuropsychological tests able to detect AD-typical pathology while taking into account varying degrees of depressive symptoms. Methods: A battery of neuropsychological tests (CERAD-NP) and the Geriatric Depression Scale (GDS) were assessed, and cerebrospinal fluid (CSF) biomarkers were obtained. After stratifying patients into CSF positive or negative and into low, moderate, or high GDS score groups, sensitivity and specificity and area under the curve (AUC) were calculated for each subtest. Results: 497 participants were included in the analyses. In patients with low GDS scores (≤10), the highest AUC (0.72) was achieved by Mini-Mental State Examination, followed by Constructional Praxis Recall and Wordlist Total Recall (AUC = 0.714, both). In patients with moderate (11–20) and high (≥21) GDS scores, Trail Making Test-B (TMT-B) revealed the highest AUCs with 0.77 and 0.82, respectively. Conclusion: Neuropsychological tests showing AD-typical pathology in participants with low GDS scores are in-line with previous results. In patients with higher GDS scores, TMT-B showed the best discrimination. This indicates the need to focus on executive function rather than on memory task results in depressed patients to explore a risk for AD.

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