Research and Findings

2008 ◽  
Vol 12 (03) ◽  
pp. 54-55
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
New Method ◽  
Genetic Determinants ◽  
Science Center

New Method Developed to Identify Genetic Determinants of Alzheimer's Disease. India Launches First Biofuels and Bioenergy Science Center.

scholarly journals IC-P-130: ICOBRAIN DM: A NEW METHOD FOR HIPPOCAMPUS AND BRAIN LOBE SEGMENTATION IN ALZHEIMER'S DISEASE

2019 ◽  
Vol 15 ◽  
pp. P107-P108
Author(s):  
Hanne Struyfs ◽  
Diana M. Sima ◽  
Eline Van Vlierberghe ◽  
Annemie Ribbens ◽  
Lene Claes ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
New Method ◽  
Brain Lobe ◽  
Lobe Segmentation

scholarly journals Genetic Determinants of Survival in Patients with Alzheimer's Disease

2015 ◽  
Vol 45 (2) ◽  
pp. 651-658 ◽  
Author(s):  
Xingbin Wang ◽  
Oscar Lopez ◽  
Robert A. Sweet ◽  
James T. Becker ◽  
Steven T. DeKosky ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Genetic Determinants

NEW METHOD SPECIFIC FOR ACETYLCHOLINESTERASE IN CEREBROSPINAL FLUID: APPLICATION TO ALZHEIMER'S DISEASE

The Lancet ◽  
1988 ◽  
Vol 332 (8610) ◽  
pp. 571-572 ◽  
Author(s):  
Anne Gitte Rasmussen ◽  
Rolf Adolfsson ◽  
Thomas Karlsson
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cerebrospinal Fluid ◽  
New Method

scholarly journals Accelerated functional brain aging in pre-clinical familial Alzheimer’s disease

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Julie Gonneaud ◽  
Alex T. Baria ◽  
Alexa Pichet Binette ◽  
Brian A. Gordon ◽  
Jasmeer P. Chhatwal ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Resting State ◽  
Brain Aging ◽  
Genetic Determinants ◽  
Resting State Functional Connectivity ◽  
Functional Brain ◽  
Clinical Phase ◽  
Amyloid Aβ ◽  
Using Data

AbstractResting state functional connectivity (rs-fMRI) is impaired early in persons who subsequently develop Alzheimer’s disease (AD) dementia. This impairment may be leveraged to aid investigation of the pre-clinical phase of AD. We developed a model that predicts brain age from resting state (rs)-fMRI data, and assessed whether genetic determinants of AD, as well as beta-amyloid (Aβ) pathology, can accelerate brain aging. Using data from 1340 cognitively unimpaired participants between 18–94 years of age from multiple sites, we showed that topological properties of graphs constructed from rs-fMRI can predict chronological age across the lifespan. Application of our predictive model to the context of pre-clinical AD revealed that the pre-symptomatic phase of autosomal dominant AD includes acceleration of functional brain aging. This association was stronger in individuals having significant Aβ pathology.

Research Findings

2005 ◽  
Vol 09 (09) ◽  
pp. 368-372
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cervical Cancer ◽  
Gene Therapy ◽  
Nk Cells ◽  
Human Genome ◽  
New Method ◽  
Elephant Shark ◽  
Research Findings ◽  
Insight Into

Forthcoming: A Vaccine for Cervical Cancer. A Safer and More Effective "Aspirin". Scientists Uncover A New Method of Producing NK Cells. Insight into the Human Genome Through the Elephant Shark. Using Gene Therapy for Alzheimer's Disease.

The molecular basis and genetic determinants of Alzheimer’s disease

1999 ◽  
Vol 9 (4) ◽  
pp. 297-304
Author(s):  
Antony J Bayer
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Great Majority ◽  
Genetic Determinants ◽  
New Techniques ◽  
Histological Techniques ◽  
Established Disease ◽  
First Time ◽  
The Brain

The first decade of the 20th century saw a dramatic growth in knowledge of neurodegenerative disease, with new histological techniques leading to the identification for the first time of distinct clinicopathological conditions, including Alzheimer’s disease (AD). The last ten years of the century (‘the decade of the brain’) has seen similar breakthroughs in our understanding of the pathogenesis of neurodegeneration, largely due to the availability of the new techniques of molecular biology. Whilst much of the research has centred on the genetics of early-onset disease, the findings have direct relevance to the great majority of elderly patients with sporadic AD. There is now a realistic prospect, in the early part of the next century, of effective disease-slowing therapies for established disease and even preventive interventions for at-risk individuals.

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