Background:
Alzheimer’s disease (AD) is characterized by the accumulation and deposition
of β-amyloid peptides leading to a progressive neuronal damage and cell loss. Besides several hypotheses
for explaining the neurodegenerative mechanisms, oxidative stress has been considered to be
one of them. Till date, there is no cure for AD, but the pathogenesis of the disease could be delayed by
the use of natural antioxidants. In this context, we decided to study the effect of kaempferol against the
transgenic Drosophila expressing human amyloid beta-42.
Method:
The AD flies were allowed to feed on the diet having 10, 20, 30 and 40µM of kaempferol for
30 days. After 30 days of exposure, the amyloid beta flies were studied for their climbing ability and
Aversive Phototaxis Suppression assay. Amyloid beta flies head homogenate was prepared for estimating
the oxidative stress markers, Caspase and acetylcholinesterase activity.
Results:
The results of the present study reveal that the exposure of AD flies to kaempferol delayed
the loss of climbing ability, memory, reduced the oxidative stress and acetylcholinesterase activity.
Conclusion:
Kaempferol could be used as a possible therapeutic agent against the progression of the
Alzheimer’s disease.
Amyloid Beta and Tau Cooperate to Cause Reversible Behavioral and Transcriptional Deficits in a Model of Alzheimer’s Disease