Non-invasive prediction tool for oesophageal variceal haemorrhage: Modification of platelet count to spleen diameter ratio to precisely determine the risk prognosis

2013 ◽  
Vol 3 (1) ◽  
pp. S98-S99
Author(s):  
I. Rankovic ◽  
D. Miletic ◽  
M. Lj. Stojkovic ◽  
D. Tomic ◽  
A. Pavlovic-Markovic ◽  
...  
Keyword(s):  
Platelet Count ◽  
Diameter Ratio ◽  
Prediction Tool ◽  
Variceal Haemorrhage ◽  
Non Invasive ◽  
Risk Prognosis

scholarly journals STUDY OF PLATELET COUNT-SPLEEN DIAMETER RATIO AS A NON-INVASIVE PREDICTOR OF OESOPHAGEAL VARICES IN PATIENTS WITH CIRRHOSIS OF LIVER

2018 ◽  
Vol 5 (2) ◽  
pp. 132-134
Author(s):  
Noas Tobias Minz ◽  
Ganeswar Sethy ◽  
Arjun Kuttikrishnan ◽  
Teena Thomas ◽  
Abinash Swain ◽  
...  
Keyword(s):  
Platelet Count ◽  
Diameter Ratio ◽  
Oesophageal Varices ◽  
Non Invasive ◽  
Cirrhosis Of Liver

scholarly journals Platelet Count/Spleen Diameter Ratio as a Predictor of Esophageal Varices in Patients with Liver Cirrhosis

2017 ◽  
Vol 15 (2) ◽  
pp. 37-40
Author(s):  
Dipendra Khadka ◽  
Sudhamshu KC ◽  
Sandip Khadka ◽  
Kiran Regmi ◽  
Pooja KC
Keyword(s):  
Liver Cirrhosis ◽  
Platelet Count ◽  
Esophageal Varices ◽  
Complete Blood Count ◽  
Liver Function Tests ◽  
Cross Sectional Study ◽  
Diameter Ratio ◽  
Cross Sectional ◽  
Predictive Values ◽  
Non Invasive

Introduction: Upper gastro-intestinal endoscopy still remains the gold standard for screening of patients suspected to have esophageal varices but not without limitations. So, this study was conducted to access the diagnostic validity and correlation between non-invasive parameters like platelet count, spleen diameter and their ratio with esophageal varices (EV) in patients with liver cirrhosis. Methods: A hospital based descriptive cross-sectional study was carried out in Liver unit of National Academy of Medical Sciences, Bir Hospital, from October 2016 to September 2017. Complete blood count, liver function tests, liver ultrasound and UGI endoscopy were done for all patients included in the study to detect esophageal varices and the platelet count/spleen diameter (PC/SD) ratio was calculated and analyzed to determine whether it can predict the presence of esophageal varices or not. Results: Total patients of liver cirrhosis studied after exclusion were 191 EV was present in 125 patients (65.4%). The platelet count/spleen diameter ratio using a cutoff value of ≤ 909 to detect EV independent of the grade had 93% sensitivity and 100% specificity and positive and negative predictive values of 100% and 91% respectively. Conclusions: PC/SD ratio now can be used as a predictor of presence of esophageal varices in liver cirrhosis.

scholarly journals Study of the correlation of oesophageal varices with portal vein diameter and ratio of platelet count to splenic diameter and their comparative evaluation in liver cirrhosis

2021 ◽  
Vol 8 (9) ◽  
pp. 1405
Author(s):  
Harpreet Singh ◽  
Sidharth Sharma ◽  
Gurminder Singh ◽  
Dania Kaur
Keyword(s):  
Liver Cirrhosis ◽  
Platelet Count ◽  
Portal Vein ◽  
Comparative Evaluation ◽  
Significant Negative Correlation ◽  
Diameter Ratio ◽  
Oesophageal Varices ◽  
Non Invasive ◽  
Vein Diameter ◽  
The Mean

Background: The aim of the study was to determine the correlation of oesophageal varices (OV) with portal vein diameter and the platelet count to splenic diameter ratio and their comparative evaluation in patients of liver cirrhosis.Methods:The present study consisted of 50 patients diagnosed with liver cirrhosis. Necessary investigations were performed in all the patients including Upper gastrointestinal (GI) endoscopy. Platelet count/spleen diameter ratio, spleen diameter and portal vein diameter were calculated for all patients and the presence and grading of OV was then comparatively evaluated. The results were systematically recorded and statistically analysed.Results: The mean age of patients was 49.82±10.23 years. 78% of patients presented with OV. The portal vein diameter, platelet count, spleen diameter and platelet count/spleen diameter ratio were significantly increased in patients with OV than those without OV (p<0.0001). Highly significant positive correlation between portal vein diameter, spleen diameter and grading of OV was seen. Platelet count/spleen diameter ratio and platelet count was significantly decreased as the grade of OV increased in the patients. There was statistically, a highly significant negative correlation between them.Conclusions: The non-invasive parameters used to detect presence of OV in liver cirrhosis were portal vein diameter and platelet count/spleen diameter ratio. Though, both seemed to be effective in predicting OV, platelet count/spleen diameter ratio proved to be slightly more significant when compared to the other. 

scholarly journals Non-Endoscopic Parameters for Predicton of Esophageal Varices

2017 ◽  
Vol 6 (2) ◽  
pp. 21-26
Author(s):  
Rahul Pathak ◽  
Roshan Jha ◽  
Prem Khadga ◽  
Shashi Sharma
Keyword(s):  
Platelet Count ◽  
Diagnostic Accuracy ◽  
Esophageal Varices ◽  
Rural Areas ◽  
Financial Burden ◽  
Tertiary Care ◽  
Diameter Ratio ◽  
Spleen Size ◽  
Non Invasive ◽  
Screening Endoscopy

Introduction: Non invasive assessment of esophageal varices may improve the management and lower the medical and financial burden related to the screening. In this study, Our aim was to validate the prediction of varices using platelet count/spleen diameter ratio and Alanine transaminase/platelet ratio index (APRI).Methods: Fifty patients with newly diagnosed and treatment naive cirrhosis underwent screening endoscopy along with hematological and ultrsonographic studies. Platelet count/spleen diameter ratio and APRI index were assessed and their diagnostic accuracy calculated. Based on previous studies, a cutoff of 909 was applied for platelet count/spleen diameter ratio and cutoff of > 1.3 for APRI. The diagnostic accuracy of both the indices were further evaluated for severity and size of varices.Results: Prevalence of varices was 36% out of which 24% were large varices. Platelet count/spleen size diameter, portal vein diameter and APRI index had significant association for prediction of presence of varices and strongly correlated with size of varices. Platelet count/spleen size diameter of 909 had diagnostic accuracy of 80.5% for prediction of varices with diagnostic accuracy being 95.8 for predicting large varices. APRI index of more than 1.3 had accuracy of 75% for predicting varices and 87.5% for accurately predicting them as large varices.Conclusions: In a resource limited country like ours, where access to specialized and tertiary care hospitals and availability of endoscopy facilities in rural areas is an issue, these non invasive parameters platelet count/spleen diameter and APRI can be taken as a safe and reliable predictor for esophageal varices.Journal of Advances in Internal Medicine 2017;06(02):21-26.

scholarly journals Platelet count/spleen diameter ratio for non-invasive prediction of high risk esophageal varices in cirrhotic patients

2009 ◽  
Vol 8 (4) ◽  
pp. 325-330 ◽  
Author(s):  
Francisco Barrera ◽  
Arnoldo Riquelme ◽  
Alejandro Soza ◽  
Álvaro Contreras ◽  
Gerty Barrios ◽  
...  
Keyword(s):  
Platelet Count ◽  
High Risk ◽  
Esophageal Varices ◽  
Diameter Ratio ◽  
Non Invasive ◽  
Cirrhotic Patients

scholarly journals Platelet count splenic diameter ratio as predictor for esophageal varices in patients with cirrhosis: a diagnostic evaluation study

2019 ◽  
Vol 7 (12) ◽  
pp. 4535
Author(s):  
Sunil Mathew ◽  
Sachin Chacko ◽  
Tomy Philip ◽  
R. N. Sharma ◽  
Kanniyan Binub
Keyword(s):  
Platelet Count ◽  
Positive Predictive Value ◽  
Esophageal Varices ◽  
Predictive Value ◽  
Evaluation Study ◽  
Diameter Ratio ◽  
Diagnostic Evaluation ◽  
Esophageal Variceal ◽  
Esophageal Variceal Bleeding ◽  
Non Invasive

Background: Esophageal variceal bleeding is one among the common complication of cirrhosis which is fatal. Latest studies are focusing more on using non-invasive techniques to classify cirrhotic patients according to their risk of having varices. The platelet count-splenic diameter ratio is considered as one such parameter and is used in predicting esophageal varices in patients with cirrhosis. Objectives of the study was to assess the utility of platelet count-splenic diameter ratio as a useful non- invasive parameter in predicting the presence/ absence /size of esophageal varices in patients with cirrhosis.Methods: Diagnostic evaluation study was done in a tertiary hospital of Kerala state India. 93 adults above the age of 18 yrs with diagnosis of cirrhosis was selected and detailed history, physical, systemic examination and imaging was done. The degree of correlation between platelet count-splenic size ratio and the presence/absence/size of esophageal varices was studied along with its utility as an independent non- invasive marker. Frequency was expressed in percentages.Results: Best cut-off for prediction of esophageal varices Grade 1 was platelet count/spleen diameter ratio of 954, which had Specificity of 85.7% and Positive predictive value of 94.1% Cut-off for prediction of Grade 2 esophageal varices was platelet count/spleen diameter ratio of 916 which had a Sensitivity of 78.9%, Specificity of 88.9%. Whereas cut-off for prediction of Grade 3 esophageal varices was a ratio of 899 which had a high Sensitivity of 88% and Negative predictive value of 93.6 % but Specificity was only 64.7% and Positive predictive value of 47.8% only.Conclusions: The platelet count splenic diameter ratio is accurate to be used as screening tool to predict the presence of Grade 2 Esophageal varices in Patients with Cirrhosis. More studies need to be done around the globe for more evidence.

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