Size-exclusion chromatography-mass spectrometry with m-nitrobenzyl alcohol as post-column additive for direct characterization of size variants of monoclonal antibodies

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Native mass spectrometry, size exclusion chromatography, and kinetic assays were employed to study trimethoprim resistance in E. coli caused by mutations P21L and W30R of dihydrofolate reductase.



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Wangjie Lv ◽  
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Vol 39 (11) ◽  
pp. 1305-1312 ◽  
Author(s):  
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Lene Hoffmeyer Ringborg ◽  
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2006 ◽  
Vol 20 (2) ◽  
pp. 734-737 ◽  
Author(s):  
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Eiman Al-muhareb ◽  
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