Comprehensive study to design advanced metal-carbide@garaphene and metal-carbide@iron oxide nanoparticles with tunable structure by the laser ablation in liquid

AbstractEmergence of nanotechnology created a drastic change in the field of cancer therapy due to their unique features in drug delivery and imaging. Polysaccharide based nanoparticles have received extensive attention in recent years as promising nanoparticle mediated drug delivery systems. Polysaccharides are endorsed with versatile merits including high drug encapsulation efficiency, efficient drug protection against chemical or enzymatic degradation, unique ability to create a controlled release and cellular internalization. In the current study, we have fabricated doxorubicin-loaded carboxymethylated PST001 coated iron oxide nanoparticles (DOX@CM-PST-IONPs) for better management of cancer. CM-PST coated iron oxide nanoparticles co-encapsulated with chemotherapeutic drug doxorubicin, can be utilized for targeted drug delivery. Biocompatible and non-toxic nanoconjugates was found to be effective in both 2-D and 3-D cell culture system with efficient cancer cell internalization. The bench-marked potential of CM-PIONPs to produce reactive oxygen species makes it a noticeable drug delivery system to compact neoplasia. These nanoconjugates can lay concrete on a better way for the elimination of cancer spheroids and tumor burden.

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Synthesis of Oxide Iron Nanoparticles Using Laser Ablation for Possible Hyperthermia Applications

Nanomaterials ◽

10.3390/nano10112099 ◽

2020 ◽

Vol 10 (11) ◽

pp. 2099

Author(s):

María J. Rivera-Chaverra ◽

Elisabeth Restrepo-Parra ◽

Carlos D. Acosta-Medina ◽

Alexandre. Mello ◽

Rogelio. Ospina

Keyword(s):

Iron Oxide ◽

Laser Ablation ◽

Iron Oxide Nanoparticles ◽

Laser Energy ◽

Great Influence ◽

Oxide Nanoparticles ◽

X Ray Diffraction ◽

Transmission Electron ◽

Heating Capacity ◽

Nanoparticles Concentration

In this work, iron oxide nanoparticles produced using the laser ablation technique were studied in order to determine the characteristics of these nanoparticles as a function of the laser energy for the possible application in magnetic hyperthermia. Nanoparticles were obtained by varying the power of the laser considering values of 90, 173, 279 and 370 mJ. The morphology of these nanoparticles was determined using the dynamic light scattering (DLS) and scattering transmission electron microscopy (STEM) techniques, confirming that the size of the particles was in the order of nanometers. A great influence of the laser power on the particle size was also observed, caused by the competition between the energy and the temperature. The composition was determined by X-ray diffraction and Raman spectroscopy, showing the presence of magnetite, maghemite and hematite. The hyperthermia measurements showed that the temperature rise of the iron oxide nanoparticles was not greatly influenced by the energy change, the heating capacity of magnetic NPs is quantified by the specific absorption rate (SAR), that tends to decrease with increasing energy, which indicates a dependence of these values on the nanoparticles concentration.

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