Anomalous dissolution behaviour of tablets prepared from sugar glass-based solid dispersions

2004 ◽  
Vol 97 (3) ◽  
pp. 441-452 ◽  
Author(s):  
D.J. van Drooge ◽  
W.L.J. Hinrichs ◽  
H.W. Frijlink
Keyword(s):  
Solid Dispersions ◽  
Dissolution Behaviour ◽  
Sugar Glass ◽  
Anomalous Dissolution

scholarly journals DISSOLUTION BEHAVIOUR OF PROPYLTHIOURACIL POLYVINYLPYRROLIDONE SOLID DISPERSIONS

1988 ◽  
Vol 11 (2) ◽  
pp. 261-272
Author(s):  
S. Abdel-Rahman ◽  
A. El-Sayed ◽  
A. Aboutaleb
Keyword(s):  
Solid Dispersions ◽  
Dissolution Behaviour

Solid-state properties, solubility, stability and dissolution behaviour of co-amorphous solid dispersions of baicalin

CrystEngComm ◽  
2020 ◽  
Vol 22 (37) ◽  
pp. 6128-6136
Author(s):  
Ashok Kumar Jangid ◽  
Poonam Jain ◽  
Kanakaraju Medicherla ◽  
Deep Pooja ◽  
Hitesh Kulhari
Keyword(s):  
Solid State ◽  
Solid Dispersion ◽  
Solid Dispersions ◽  
Amorphous Solid ◽  
Amorphous Solid Dispersions ◽  
Dissolution Behaviour

Formation of different baicalin co-former based solid dispersion formulations, which demonstrate improved solubility and dissolution performance.

Solubility Enhancement of Poorly Soluble Drug Simvastatin by Solid Dispersion Technique

2016 ◽  
Vol 2 (2) ◽  
pp. 91-95
Author(s):  
Neelima Rani T ◽  
Pavani A ◽  
Sobhita Rani P ◽  
Srilakshmi N
Keyword(s):  
Dissolution Rate ◽  
Drug Carrier ◽  
Solid Dispersions ◽  
Aqueous Solubility ◽  
Onset Of Action ◽  
Kneading Method ◽  
Wetting Property ◽  
Poorly Soluble ◽  
Dispersion Technique ◽  
Low Solubility

This study aims to formulate solid dispersions (SDs) of Simvastatin (SIM) to improve the aqueous solubility, dissolution rate and to facilitate faster onset of action. Simvastatin is a BCS class II drug having low solubility & therefore low oral bioavailability. In the present study, SDs of simvastatin different drug-carrier ratios were prepared by kneading method. The results showed that simvastatin solubility & dissolution rate enhanced with polymer SSG in the ratio 1:7 due to increase in wetting property or possibly may be due to change in crystallinity of the drug.

Solid Dispersions: A Review

2014 ◽  
Vol 4 (2) ◽  
Author(s):  
Sumant Saini ◽  
Yashwant .
Keyword(s):  
Solid Dispersions ◽  
Physicochemical Characterization ◽  
Water Soluble ◽  
Absolute Minimum ◽  
Technology Transfers ◽  
Molecular Arrangement ◽  
Water Soluble Drugs ◽  
Carrier Solvent ◽  
Preparation Techniques ◽  
Selection Of

Solid dispersions are one of the most promising strategies to improve the oral bioavailability of poorly water soluble drugs. By reducing drug particle size to the absolute minimum, and hence improving drug wettability, bioavailability may be significantly improved. This article reviews the various preparation techniques for solid dispersion and compiles some of the recent technology transfers. The different types of solid dispersions based on the molecular arrangement have been highlighted. Some of the practical aspects to be considered for the preparation of solid dispersions, such as selection of carrier, solvent and methods of physicochemical characterization, along with an insight into the molecular arrangement of drugs in solid dispersions are also discussed. In this review, it is intended to discuss the recent advances related on the area of solid dispersions.

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