An aluminum adjuvant-integrated nano-MOF as antigen delivery system to induce strong humoral and cellular immune responses

2019 ◽  
Vol 300 ◽  
pp. 81-92 ◽  
Author(s):  
Xiaofang Zhong ◽  
Yunting Zhang ◽  
Lu Tan ◽  
Tao Zheng ◽  
Yingying Hou ◽  
...  
Keyword(s):  
Immune Responses ◽  
Delivery System ◽  
Antigen Delivery ◽  
Cellular Immune Responses ◽  
Cellular Immune

scholarly journals Eucommia ulmoides Leaf Polysaccharide in Conjugation with Ovalbumin Act as Delivery System Can Improve Immune Response

Pharmaceutics ◽  
2021 ◽  
Vol 13 (9) ◽  
pp. 1384
Author(s):  
Haibo Feng ◽  
Jie Yang ◽  
Hui Zhi ◽  
Xin Hu ◽  
Yan Yang ◽  
...  
Keyword(s):  
Immune Response ◽  
Immune Responses ◽  
Delivery System ◽  
Physicochemical Characteristics ◽  
Cellular Immune Responses ◽  
Ethylcarbodiimide Hydrochloride ◽  
Ifn Γ ◽  
Cellular Immune

In this investigation, to maximize the desired immunoenhancement effects of PsEUL and stimulate an efficient humoral and cellular immune response against an antigen, PsEUL and the model antigen ovalbumin (OVA) were coupled using the N-(3-dimethylaminopropyl)-N′-ethylcarbodiimide hydrochloride (EDC) reaction to yield a novel delivery system (PsEUL-OVA). The physicochemical characteristics and immune regulation effects of this new system were investigated. We found the yield of this EDC method to be 46.25%. In vitro, PsEUL-OVA (200 μg mL−1) could enhance macrophage proliferation and increase their phagocytic efficiency. In vivo, PsEUL-OVA could significantly increase the levels of OVA-specific antibody (IgG, IgG1, IgG2a, and IgG2b) titers and cytokine (IL-2, IL-4, IL-6, IFN-γ) levels. Additionally, it could activate T lymphocytes and facilitate the maturation of dendritic cells (DCs). These findings collectively suggested that PsEUL-OVA induced humoral and cellular immune responses by promoting the phagocytic activity of macrophages and DCs. Taken together, these results revealed that PsEUL-OVA had the potential to improve immune responses and provide a promising theoretical basis for the design of a novel delivery system.

Quaternized Cationic Carbon Dots as Antigen Delivery Systems for Improving Humoral and Cellular Immune Responses

2020 ◽  
Vol 3 (9) ◽  
pp. 9449-9461 ◽  
Author(s):  
Shaomei Huang ◽  
Bowen Li ◽  
Usama Ashraf ◽  
Qi Li ◽  
Xingchang Lu ◽  
...  
Keyword(s):  
Immune Responses ◽  
Carbon Dots ◽  
Delivery Systems ◽  
Antigen Delivery ◽  
Cellular Immune Responses ◽  
Cellular Immune ◽  
Antigen Delivery Systems

Novel Vaccine Delivery System Induces Robust Humoral and Cellular Immune Responses Based on Multiple Mechanisms

2013 ◽  
Vol 3 (5) ◽  
pp. 670-681 ◽  
Author(s):  
Yue-Qi Wang ◽  
Jie Wu ◽  
Qing-Ze Fan ◽  
Meng Zhou ◽  
Zhan-Guo Yue ◽  
...  
Keyword(s):  
Immune Responses ◽  
Delivery System ◽  
Vaccine Delivery ◽  
Vaccine Delivery System ◽  
Cellular Immune Responses ◽  
Cellular Immune
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