Target engagement and intracellular delivery of mono- and bivalent LDL receptor-binding peptide-cargo conjugates: Implications for the rational design of new targeted drug therapies

2019 ◽  
Vol 314 ◽  
pp. 141-161
Author(s):  
K. Varini ◽  
P. Lécorché ◽  
R. Sonnette ◽  
F. Gassiot ◽  
B. Broc ◽  
...  
Keyword(s):  
Receptor Binding ◽  
Rational Design ◽  
Ldl Receptor ◽  
Intracellular Delivery ◽  
Target Engagement ◽  
Binding Peptide ◽  
Targeted Drug ◽  
Targeted Drug Therapies

Expression of LDL Receptor Binding Determinants in Very Low Density Lipoproteinsa

1985 ◽  
Vol 454 (1) ◽  
pp. 239-247 ◽  
Author(s):  
WILLIAM A. BRADLEY ◽  
ANTONIO M. GOTTO ◽  
SANDRA H. GIANTURCO
Keyword(s):  
Receptor Binding ◽  
Ldl Receptor ◽  
Low Density ◽  
Binding Determinants

Selective Intracellular Delivery of Ganglioside GM3-Binding Peptide through Caveolae/Raft-Mediated Endocytosis

2017 ◽  
Vol 18 (2) ◽  
pp. 355-362 ◽  
Author(s):  
Teruhiko Matsubara ◽  
Ryohei Otani ◽  
Miki Yamashita ◽  
Haruka Maeno ◽  
Hanae Nodono ◽  
...  
Keyword(s):  
Intracellular Delivery ◽  
Ganglioside Gm3 ◽  
Binding Peptide

scholarly journals A randomized trial and novel SPR technique identifies altered lipoprotein-LDL receptor binding as a mechanism underlying elevated LDL-cholesterol in APOE4s

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
M. V. Calabuig-Navarro ◽  
K. G. Jackson ◽  
C. F. Kemp ◽  
D. S. Leake ◽  
C. M. Walden ◽  
...  
Keyword(s):  
Randomized Trial ◽  
Receptor Binding ◽  
Ldl Cholesterol ◽  
Ldl Receptor

Rational design of hollow mesoporous titania nanoparticles loaded with curcumin for UV-controlled release and targeted drug delivery

2021 ◽  
Vol 32 (20) ◽  
pp. 205604
Author(s):  
Zhuoxian Mai ◽  
Jiali Chen ◽  
Qingyun Cao ◽  
Yang Hu ◽  
Xianming Dong ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Controlled Release ◽  
Targeted Drug Delivery ◽  
Rational Design ◽  
Titania Nanoparticles ◽  
Mesoporous Titania ◽  
Targeted Drug

Orthopaedic surgery in the palliation of cancer

2021 ◽  
pp. 839-848
Author(s):  
Mohamed Yakoub ◽  
John Healey
Keyword(s):  
Bone Disease ◽  
Chronic Condition ◽  
Orthopaedic Surgery ◽  
Functional Limitation ◽  
Metastatic Bone Disease ◽  
Site Specific ◽  
Pain Disability ◽  
Targeted Drug ◽  
Surgical Treatments ◽  
Targeted Drug Therapies

Metastatic spread of cancer to bone is frequent and causes pain, disability, and functional limitation. Non-surgical treatments such as chemotherapy and hormone therapy are effective in early disease. Administration of bisphosphonates or osteoprotegerin inhibitors prevent new ‘bone events’, thereby avoiding pain, radiation, and surgery. Radiotherapy arrests disease and relieves pain in many cases. Surgery is needed when the bone is weak or fractured. It effectively relieves pain and preserves function by bypassing the deficient bone with site-specific reconstructive surgery. Surgery should be selected based on projections of patient survival. New tools to make these projections are now available (https://www.pathfx.org/). New targeted drug therapies appear to be changing metastatic bone disease into a more chronic condition. This will alter the management of local disease in many histological subtypes of metastatic cancers.

scholarly journals A Brain Tumor/Organotypic Slice Co-culture System for Studying Tumor Microenvironment and Targeted Drug Therapies

10.3791/53304 ◽  
2015 ◽  
Author(s):  
Emily J. Chadwick ◽  
David P. Yang ◽  
Mariella G. Filbin ◽  
Emanuele Mazzola ◽  
Yu Sun ◽  
...  
Keyword(s):  
Brain Tumor ◽  
Tumor Microenvironment ◽  
Culture System ◽  
Targeted Drug ◽  
Targeted Drug Therapies

Sequence of the putative LDL receptor binding regions of apolipoprotein B in mouse and hamster

Gene ◽  
1990 ◽  
Vol 95 (2) ◽  
pp. 307-308 ◽  
Author(s):  
T.J. Smith ◽  
D. Hautamaa ◽  
N. Maeda
Keyword(s):  
Receptor Binding ◽  
Apolipoprotein B ◽  
Ldl Receptor ◽  
Binding Regions

scholarly journals Absence of Hyperlipidemia in LDL Receptor-Deficient Mice Having Apolipoprotein B100 Without the Putative Receptor-Binding Sequences

2008 ◽  
Vol 28 (10) ◽  
pp. 1745-1752 ◽  
Author(s):  
Lance A. Johnson ◽  
Michael K. Altenburg ◽  
Rosemary L. Walzem ◽  
Lori T. Scanga ◽  
Nobuyo Maeda
Keyword(s):  
Receptor Binding ◽  
Ldl Receptor ◽  
Putative Receptor ◽  
Apolipoprotein B100 ◽  
Deficient Mice
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