Microvesicles transfer mitochondria and increase mitochondrial function in brain endothelial cells

2021 ◽  
Author(s):  
Anisha D'Souza ◽  
Amelia Burch ◽  
Kandarp M. Dave ◽  
Aravind Sreeram ◽  
Michael J. Reynolds ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Mitochondrial Function ◽  
Brain Endothelial Cells

scholarly journals Estrogen-Receptor-Mediated Protection of Cerebral Endothelial Cell Viability and Mitochondrial Function after Ischemic Insult in vitro

2009 ◽  
Vol 30 (3) ◽  
pp. 545-554 ◽  
Author(s):  
Jiabin Guo ◽  
Diana N Krause ◽  
James Horne ◽  
John H Weiss ◽  
Xuejun Li ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Estrogen Receptor ◽  
Endothelial Cell ◽  
Cell Viability ◽  
Mitochondrial Function ◽  
Protective Effects ◽  
Brain Endothelial Cells ◽  
Ischemic Insult ◽  
Mitochondrial Superoxide

Protective effects of estrogen against experimental stroke and neuronal ischemic insult are well-documented, but it is not known whether estrogen prevents ischemic injury to brain endothelium, a key component of the neurovascular unit. Increasing evidence indicates that estrogen exerts protective effects through mitochondrial mechanisms. We previously found 17β-estradiol (E2) to improve mitochondrial efficiency and reduce mitochondrial superoxide in brain blood vessels and endothelial cells. Thus we hypothesized E2 will preserve mitochondrial function and protect brain endothelial cells against ischemic damage. To test this, an in vitro ischemic model, oxygen-glucose deprivation (OGD)/reperfusion, was applied to immortalized mouse brain endothelial cells (bEnd.3). OGD/reperfusion-induced cell death was prevented by long-term (24, 48 h), but not short-term (0.5, 12 h), pretreatment with 10 nmol/L E2. Protective effects of E2 on endothelial cell viability were mimicked by an estrogen-receptor (ER) agonist selective for ERα (PPT), but not by one selective for ERβ (DPN). In addition, E2 significantly decreased mitochondrial superoxide and preserved mitochondrial membrane potential and ATP levels in early stages of OGD/reperfusion. All of the E2 effects were blocked by the ER antagonist, ICI-182,780. These findings indicate that E2 can preserve endothelial mitochondrial function and provide protection against ischemic injury through ER-mediated mechanisms.

Polymer-coated nanoparticles and their effects on mitochondrial function in brain endothelial cells

2019 ◽  
Vol 385 ◽  
pp. 114800
Author(s):  
Aniela Bittner ◽  
Angélique Dominique Ducray ◽  
Michael Hubert Stoffel ◽  
Andrea Felser ◽  
Meike Mevissen
Keyword(s):  
Endothelial Cells ◽  
Mitochondrial Function ◽  
Brain Endothelial Cells ◽  
Coated Nanoparticles

scholarly journals P. falciparum Isolate-Specific Distinct Patterns of Induced Apoptosis in Pulmonary and Brain Endothelial Cells

PLoS ONE ◽  
2014 ◽  
Vol 9 (3) ◽  
pp. e90692 ◽  
Author(s):  
Nadine N'Dilimabaka ◽  
Zacharie Taoufiq ◽  
Sergine Zougbédé ◽  
Serge Bonnefoy ◽  
Audrey Lorthiois ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Brain Endothelial Cells ◽  
Falciparum Isolate ◽  
Induced Apoptosis

scholarly journals Febuxostat Prevents the Cytotoxicity of Propofol in Brain Endothelial Cells

ACS Omega ◽  
2021 ◽  
Author(s):  
Jianli Hao ◽  
Weiqing Zhang ◽  
Rui Tong ◽  
Zeqing Huang
Keyword(s):  
Endothelial Cells ◽  
Brain Endothelial Cells

scholarly journals Function of Multidrug Resistance Transporters is Disrupted by Infection Mimics in Human Brain Endothelial Cells

2021 ◽  
pp. 1860616
Author(s):  
Guinever Eustaquio Do Imperio ◽  
Phetcharawan Lye ◽  
Enrrico Bloise ◽  
Stephen G. Matthews
Keyword(s):  
Endothelial Cells ◽  
Multidrug Resistance ◽  
Human Brain ◽  
Brain Endothelial Cells ◽  
Multidrug Resistance Transporters

Delivery of Human Fibroblast Growth Factor-1 Gene to Brain by Modified Rat Brain Endothelial Cells

2002 ◽  
Vol 67 (4) ◽  
pp. 1643-1652 ◽  
Author(s):  
P. Johnston ◽  
M. Nam ◽  
M. A. Hossain ◽  
R. R. Indurti ◽  
J. L. Mankowski ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Growth Factor ◽  
Rat Brain ◽  
Fibroblast Growth Factor ◽  
Human Fibroblast ◽  
Fibroblast Growth ◽  
Brain Endothelial Cells ◽  
Rat Brain Endothelial Cells
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