Co-culture of infrapatellar fat pad–derived mesenchymal stromal cells and articular chondrocytes in plasma clot for cartilage tissue engineering

Cytotherapy ◽  
2017 ◽  
Vol 19 (7) ◽  
pp. 881-894 ◽  
Author(s):  
Aditya Arora ◽  
M. Sriram ◽  
Anjaney Kothari ◽  
Dhirendra S. Katti
Keyword(s):  
Tissue Engineering ◽  
Mesenchymal Stromal Cells ◽  
Stromal Cells ◽  
Articular Chondrocytes ◽  
Cartilage Tissue Engineering ◽  
Cartilage Tissue ◽  
Infrapatellar Fat Pad ◽  
Fat Pad ◽  
Plasma Clot

scholarly journals Chondrogenic Potential of Dental-Derived Mesenchymal Stromal Cells

Osteology ◽  
2021 ◽  
Vol 1 (3) ◽  
pp. 149-174
Author(s):  
Naveen Jeyaraman ◽  
Gollahalli Shivashankar Prajwal ◽  
Madhan Jeyaraman ◽  
Sathish Muthu ◽  
Manish Khanna
Keyword(s):  
Tissue Engineering ◽  
Mesenchymal Stromal Cells ◽  
Tissue Regeneration ◽  
Stromal Cells ◽  
Cartilage Tissue Engineering ◽  
Cartilage Regeneration ◽  
Cartilage Tissue ◽  
Dentin Matrix

The field of tissue engineering has revolutionized the world in organ and tissue regeneration. With the robust research among regenerative medicine experts and researchers, the plausibility of regenerating cartilage has come into the limelight. For cartilage tissue engineering, orthopedic surgeons and orthobiologists use the mesenchymal stromal cells (MSCs) of various origins along with the cytokines, growth factors, and scaffolds. The least utilized MSCs are of dental origin, which are the richest sources of stromal and progenitor cells. There is a paradigm shift towards the utilization of dental source MSCs in chondrogenesis and cartilage regeneration. Dental-derived MSCs possess similar phenotypes and genotypes like other sources of MSCs along with specific markers such as dentin matrix acidic phosphoprotein (DMP) -1, dentin sialophosphoprotein (DSPP), alkaline phosphatase (ALP), osteopontin (OPN), bone sialoprotein (BSP), and STRO-1. Concerning chondrogenicity, there is literature with marginal use of dental-derived MSCs. Various studies provide evidence for in-vitro and in-vivo chondrogenesis by dental-derived MSCs. With such evidence, clinical trials must be taken up to support or refute the evidence for regenerating cartilage tissues by dental-derived MSCs. This article highlights the significance of dental-derived MSCs for cartilage tissue regeneration.

scholarly journals Comparative analysis of mesenchymal stromal cells from different tissue sources in respect to articular cartilage tissue engineering

2016 ◽  
Vol 35 (02) ◽  
pp. 207-214 ◽  
Author(s):  
Ľuboš Danišovič ◽  
Martin Boháč ◽  
Radoslav Zamborský ◽  
Lenka Oravcová ◽  
Zuzana Provazníková ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Comparative Analysis ◽  
Articular Cartilage ◽  
Mesenchymal Stromal Cells ◽  
Stromal Cells ◽  
Cartilage Tissue Engineering ◽  
Cartilage Tissue

scholarly journals Cartilage tissue engineering: adult human mesenchymal stromal cells and collagen biomaterials

2014 ◽  
Vol 22 ◽  
pp. S154 ◽  
Author(s):  
C. Sanjurjo-Rodríguez ◽  
A.H. Martínez Sánchez ◽  
T. Hermida-Gómez ◽  
I.M. Fuentes ◽  
J. Buján ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Mesenchymal Stromal Cells ◽  
Stromal Cells ◽  
Cartilage Tissue Engineering ◽  
Cartilage Tissue ◽  
Human Mesenchymal Stromal Cells ◽  
Adult Human

scholarly journals The clinical efficacy of arthroscopic therapy with knee infrapatellar fat pad cell concentrates in treating knee cartilage lesion: a prospective, randomized, and controlled study

2021 ◽  
Vol 16 (1) ◽  
Author(s):  
Yiqin Zhou ◽  
Haobo Li ◽  
Dong Xiang ◽  
Jiahua Shao ◽  
Qiwei Fu ◽  
...  
Keyword(s):  
Clinical Efficacy ◽  
Mesenchymal Stromal Cells ◽  
Stromal Cells ◽  
Knee Arthroscopy ◽  
Infrapatellar Fat Pad ◽  
Control Group ◽  
Knee Cartilage ◽  
Fat Pad ◽  
Group 12 ◽  
Significant Difference

Abstract Introduction To evaluate the clinical efficacy of arthroscopic therapy with infrapatellar fat pad cell concentrates in treating knee cartilage lesions, we conducted a prospective randomized single-blind clinical study of controlled method. Methods Sixty cases from Shanghai Changzheng Hospital from April 2018 to December 2019 were chosen and randomly divided into 2 groups equally. Patients in the experiment group were treated through knee arthroscopy with knee infrapatellar fat pad cell concentrates containing mesenchymal stromal cells, while patients in the control group were treated through regular knee arthroscopic therapy. VAS and WOMAC scores were assessed at pre-operation, and 6 weeks, 12 weeks, 6 months, and 12 months after intervention. MORCART scores were assessed at pre-operation and 12 months after intervention. Results Twenty-nine cases in the experiment group and 28 cases in the control group were followed up. No significant difference in VAS, WOMAC, and MOCART scores were found between the two groups before surgery (P > 0.05). The WOMAC total and WOMAC function scores of the experiment group were significantly lower than those of the control group 6 months and 12 months after surgery (P < 0.05). The VAS rest and VAS motion scores of the experiment group were found significantly lower than those of the control group 12 months after surgery (P < 0.05). The MOCART scores of the experiment group were found significantly higher compared with the control group 12 months after surgery (P < 0.05). No significant difference in WOMAC stiffness scores were found between the two groups. Conclusions The short-term results of our study are encouraging and demonstrate that knee arthroscopy with infrapatellar fat pad cell concentrates containing mesenchymal stromal cells is safe and provides assistance in reducing pain and improving function in patients with knee cartilage lesions. Trial registration ChiCTR1800015379. Registered on 27 March 2018, http://www.chictr.org.cn/showproj.aspx?proj=25901.

Freshly isolated stromal cells from the infrapatellar fat pad are suitable for a one-step surgical procedure to regenerate cartilage tissue

Cytotherapy ◽  
2009 ◽  
Vol 11 (8) ◽  
pp. 1052-1064 ◽  
Author(s):  
Wouter J.F.M. Jurgens ◽  
Annemieke van Dijk ◽  
Behrouz Zandieh Doulabi ◽  
Frank B. Niessen ◽  
Marco J.P.F. Ritt ◽  
...  
Keyword(s):  
Stromal Cells ◽  
Surgical Procedure ◽  
Cartilage Tissue ◽  
Infrapatellar Fat Pad ◽  
Fat Pad ◽  
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