Cutaneous consequences of inhibiting EGF receptor signaling in vivo: Normal hair follicle development, but retarded hair cycle induction and inhibition of adipocyte growth in EgfrWa5 mice

2010 ◽  
Vol 57 (3) ◽  
pp. 155-161 ◽  
Author(s):  
Koji Sugawara ◽  
Marlon R. Schneider ◽  
Maik Dahlhoff ◽  
Jennifer E. Kloepper ◽  
Ralf Paus
Keyword(s):  
Hair Follicle ◽  
Egf Receptor ◽  
Follicle Development ◽  
Receptor Signaling ◽  
Hair Cycle ◽  
Normal Hair ◽  
Hair Follicle Development

scholarly journals Epithelium-Mesenchyme Interactions Control the Activity of Peroxisome Proliferator-Activated Receptor β/δ during Hair Follicle Development

2005 ◽  
Vol 25 (5) ◽  
pp. 1696-1712 ◽  
Author(s):  
Nicolas Di-Poï ◽  
Chuan Young Ng ◽  
Nguan Soon Tan ◽  
Zhongzhou Yang ◽  
Brian A. Hemmings ◽  
...  
Keyword(s):  
Hair Follicle ◽  
Hair Follicles ◽  
Peroxisome Proliferator ◽  
Follicle Development ◽  
Paracrine Factor ◽  
Peroxisome Proliferator Activated Receptor ◽  
Proliferation And Apoptosis ◽  
Normal Hair ◽  
Hair Follicle Development

ABSTRACT Hair follicle morphogenesis depends on a delicate balance between cell proliferation and apoptosis, which involves epithelium-mesenchyme interactions. We show that peroxisome proliferator-activated receptor beta/delta (PPARβ/δ) and Akt1 are highly expressed in follicular keratinocytes throughout hair follicle development. Interestingly, PPARβ/δ- and Akt1-deficient mice exhibit similar retardation of postnatal hair follicle morphogenesis, particularly at the hair peg stage, revealing a new important function for both factors in the growth of early hair follicles. We demonstrate that a time-regulated activation of the PPARβ/δ protein in follicular keratinocytes involves the up-regulation of the cyclooxygenase 2 enzyme by a mesenchymal paracrine factor, the hepatocyte growth factor. Subsequent PPARβ/δ-mediated temporal activation of the antiapoptotic Akt1 pathway in vivo protects keratinocytes from hair pegs against apoptosis, which is required for normal hair follicle development. Together, these results demonstrate that epithelium-mesenchyme interactions in the skin regulate the activity of PPARβ/δ during hair follicle development via the control of ligand production and provide important new insights into the molecular biology of hair growth.

Reconstitution of Hair Follicle Development In Vivo: Determination of Follicle Formation, Hair Growth, and Hair Quality by Dermal Cells

1993 ◽  
Vol 100 (3) ◽  
pp. 229-236 ◽  
Author(s):  
Wendy C. Weinberg ◽  
Linda V. Goodman ◽  
Carmen George ◽  
David L. Morgan ◽  
Steve Ledbetter ◽  
...  
Keyword(s):  
Hair Follicle ◽  
Hair Growth ◽  
Follicle Development ◽  
Hair Follicle Development ◽  
Dermal Cells

scholarly journals Expression of RNA-Binding Protein Musashi in Hair Follicle Development and Hair Cycle Progression

2006 ◽  
Vol 168 (1) ◽  
pp. 80-92 ◽  
Author(s):  
Yoriko Sugiyama-Nakagiri ◽  
Masashi Akiyama ◽  
Shinsuke Shibata ◽  
Hideyuki Okano ◽  
Hiroshi Shimizu
Keyword(s):  
Hair Follicle ◽  
Rna Binding ◽  
Binding Protein ◽  
Rna Binding Protein ◽  
Follicle Development ◽  
Hair Cycle ◽  
Cycle Progression ◽  
Hair Follicle Development

scholarly journals Targeted Disruption of the Protein Kinase SGK3/CISK Impairs Postnatal Hair Follicle Development

2004 ◽  
Vol 15 (9) ◽  
pp. 4278-4288 ◽  
Author(s):  
James A. McCormick ◽  
Yuxi Feng ◽  
Kevin Dawson ◽  
Martin J. Behne ◽  
Benjamin Yu ◽  
...  
Keyword(s):  
Hair Follicle ◽  
Gene Transcription ◽  
Cultured Cells ◽  
Nuclear Accumulation ◽  
Follicle Development ◽  
Phosphatidylinositol 3 Kinase ◽  
Targeted Disruption ◽  
Hair Follicle Development ◽  
Close Relatives

Members of the serum- and glucocorticoid-regulated kinase (SGK) family are important mediators of growth factor and hormone signaling that, like their close relatives in the Akt family, are regulated by lipid products of phosphatidylinositol-3-kinase. SGK3 has been implicated in the control of cell survival and regulation of ion channel activity in cultured cells. To begin to dissect the in vivo functions of SGK3, we generated and characterized Sgk3 null mice. These mice are viable and fertile, and in contrast to mice lacking SGK1 or Akt2, respectively, display normal sodium handling and glucose tolerance. However, although normal at birth, by postpartum day 4 they have begun to display an unexpected defect in hair follicle morphogenesis. The abnormality in hair follicle development is preceded by a defect in proliferation and nuclear accumulation of β-catenin in hair bulb keratinocytes. Furthermore, in cultured keratinocytes, heterologous expression of SGK3 potently modulates activation of β-catenin/Lef-1–mediated gene transcription. These data establish a role for SGK3 in normal postnatal hair follicle development, possibly involving effects on β-catenin/Lef-1–mediated gene transcription.

scholarly journals Betacellulin Regulates Hair Follicle Development and Hair Cycle Induction and Enhances Angiogenesis in Wounded Skin

2008 ◽  
Vol 128 (5) ◽  
pp. 1256-1265 ◽  
Author(s):  
Marlon R. Schneider ◽  
Maria Antsiferova ◽  
Laurence Feldmeyer ◽  
Maik Dahlhoff ◽  
Philippe Bugnon ◽  
...  
Keyword(s):  
Hair Follicle ◽  
Follicle Development ◽  
Hair Cycle ◽  
Hair Follicle Development

The Nude Mouse Skin Phenotype: The Role of Foxn1 in Hair Follicle Development and Cycling

2001 ◽  
Vol 71 (2) ◽  
pp. 171-178 ◽  
Author(s):  
Lars Mecklenburg ◽  
Motonobu Nakamura ◽  
John P. Sundberg ◽  
Ralf Paus
Keyword(s):  
Hair Follicle ◽  
Nude Mouse ◽  
Mouse Skin ◽  
Follicle Development ◽  
Hair Follicle Development

scholarly journals Factors Mediating the Interactions Between Epidermal and Dermal Cells in Skin Grafts that Might Be Important for Hair Follicle Development

1995 ◽  
Vol 104 (5) ◽  
pp. 21-22 ◽  
Author(s):  
Tonja Kartasova ◽  
Aline B. Scandurro ◽  
Mitchell F. Denning ◽  
Stuart H. Yuspa ◽  
Ulrike Lichti ◽  
...  
Keyword(s):  
Hair Follicle ◽  
Follicle Development ◽  
Skin Grafts ◽  
Hair Follicle Development ◽  
Dermal Cells

scholarly journals Using WGCNA (weighted gene co-expression network analysis) to identify the hub genes of skin hair follicle development in fetus stage of Inner Mongolia cashmere goat

PLoS ONE ◽  
2020 ◽  
Vol 15 (12) ◽  
pp. e0243507
Author(s):  
Zhihong Wu ◽  
Erhan Hai ◽  
Zhengyang Di ◽  
Rong Ma ◽  
Fangzheng Shang ◽  
...  
Keyword(s):  
Network Analysis ◽  
Hair Follicle ◽  
Quantitative Polymerase Chain Reaction ◽  
Correlation Coefficients ◽  
Hair Follicles ◽  
Functional Enrichment ◽  
Follicle Development ◽  
Hub Genes ◽  
Cashmere Goats ◽  
Hair Follicle Development

Objective Mature hair follicles represent an important stage of hair follicle development, which determines the stability of hair follicle structure and its ability to enter the hair cycle. Here, we used weighted gene co-expression network analysis (WGCNA) to identify hub genes of mature skin and hair follicles in Inner Mongolian cashmere goats. Methods We used transcriptome sequencing data for the skin of Inner Mongolian cashmere goats from fetal days 45–135 days, and divided the co expressed genes into different modules by WGCNA. Characteristic values were used to screen out modules that were highly expressed in mature skin follicles. Module hub genes were then selected based on the correlation coefficients between the gene and module eigenvalue, gene connectivity, and Gene Ontology (GO)/Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis. The results were confirmed by quantitative polymerase chain reaction (qPCR). Results Ten modules were successfully defined, of which one, with a total of 3166 genes, was selected as a specific module through sample and gene expression pattern analyses. A total of 584 candidate hub genes in the module were screened by the correlation coefficients between the genes and module eigenvalue and gene connectivity. Finally, GO/KEGG functional enrichment analyses detected WNT10A as a key gene in the development and maturation of skin hair follicles in fetal Inner Mongolian cashmere goats. qPCR showed that the expression trends of 13 genes from seven fetal skin samples were consistent with the sequencing results, indicating that the sequencing results were reliable.n

scholarly journals MLL histone methylases in estrogen‐mediated regulation of HOX genes involved in hair follicle development and leukemia

2010 ◽  
Vol 24 (S1) ◽  
Author(s):  
Subhrangsu S Mandal ◽  
Khairul I Ansari ◽  
Imran Hussain ◽  
Sahba Kasiri ◽  
Bishakha Shrestha
Keyword(s):  
Hair Follicle ◽  
Hox Genes ◽  
Follicle Development ◽  
Hair Follicle Development

scholarly journals Notch Signaling in Hair Follicle Development

2017 ◽  
Vol 15 (3) ◽  
pp. 377-386
Author(s):  
Seunghee Bae ◽  
Ki-Heon Lee ◽  
In-Ho Lee ◽  
Mi Kyung Kim ◽  
Jae Ho Lee
Keyword(s):  
Notch Signaling ◽  
Hair Follicle ◽  
Follicle Development ◽  
Hair Follicle Development
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