Reconstitution of Hair Follicle Development In Vivo: Determination of Follicle Formation, Hair Growth, and Hair Quality by Dermal Cells

1993 ◽  
Vol 100 (3) ◽  
pp. 229-236 ◽  
Author(s):  
Wendy C. Weinberg ◽  
Linda V. Goodman ◽  
Carmen George ◽  
David L. Morgan ◽  
Steve Ledbetter ◽  
...  
Keyword(s):  
Hair Follicle ◽  
Hair Growth ◽  
Follicle Development ◽  
Hair Follicle Development ◽  
Dermal Cells

scholarly journals Factors Mediating the Interactions Between Epidermal and Dermal Cells in Skin Grafts that Might Be Important for Hair Follicle Development

1995 ◽  
Vol 104 (5) ◽  
pp. 21-22 ◽  
Author(s):  
Tonja Kartasova ◽  
Aline B. Scandurro ◽  
Mitchell F. Denning ◽  
Stuart H. Yuspa ◽  
Ulrike Lichti ◽  
...  
Keyword(s):  
Hair Follicle ◽  
Follicle Development ◽  
Skin Grafts ◽  
Hair Follicle Development ◽  
Dermal Cells

scholarly journals Advances in Regenerative Stem Cell Therapy in Androgenic Alopecia and Hair Loss: Wnt Pathway, Growth-Factor, and Mesenchymal Stem Cell Signaling Impact Analysis on Cell Growth and Hair Follicle Development

Cells ◽  
2019 ◽  
Vol 8 (5) ◽  
pp. 466 ◽  
Author(s):  
Pietro Gentile ◽  
Simone Garcovich
Keyword(s):  
Stem Cells ◽  
Stem Cell ◽  
Cell Growth ◽  
Mesenchymal Stem Cell ◽  
Hair Follicle ◽  
Hair Loss ◽  
Hair Growth ◽  
Follicle Development ◽  
Hair Regrowth ◽  
Hair Follicle Development

The use of stem cells has been reported to improve hair regrowth in several therapeutic strategies, including reversing the pathological mechanisms, that contribute to hair loss, regeneration of hair follicles, or creating hair using the tissue-engineering approach. Although various promising stem cell approaches are progressing via pre-clinical models to clinical trials, intraoperative stem cell treatments with a one-step procedure offer a quicker result by incorporating an autologous cell source without manipulation, which may be injected by surgeons through a well-established clinical practice. Many authors have concentrated on adipose-derived stromal vascular cells due to their ability to separate into numerous cell genealogies, platelet-rich plasma for its ability to enhance cell multiplication and neo-angiogenesis, as well as human follicle mesenchymal stem cells. In this paper, the significant improvements in intraoperative stem cell approaches, from in vivo models to clinical investigations, are reviewed. The potential regenerative instruments and functions of various cell populaces in the hair regrowth process are discussed. The addition of Wnt signaling in dermal papilla cells is considered a key factor in stimulating hair growth. Mesenchymal stem cell-derived signaling and growth factors obtained by platelets influence hair growth through cellular proliferation to prolong the anagen phase (FGF-7), induce cell growth (ERK activation), stimulate hair follicle development (β-catenin), and suppress apoptotic cues (Bcl-2 release and Akt activation).

scholarly journals Epithelium-Mesenchyme Interactions Control the Activity of Peroxisome Proliferator-Activated Receptor β/δ during Hair Follicle Development

2005 ◽  
Vol 25 (5) ◽  
pp. 1696-1712 ◽  
Author(s):  
Nicolas Di-Poï ◽  
Chuan Young Ng ◽  
Nguan Soon Tan ◽  
Zhongzhou Yang ◽  
Brian A. Hemmings ◽  
...  
Keyword(s):  
Hair Follicle ◽  
Hair Follicles ◽  
Peroxisome Proliferator ◽  
Follicle Development ◽  
Paracrine Factor ◽  
Peroxisome Proliferator Activated Receptor ◽  
Proliferation And Apoptosis ◽  
Normal Hair ◽  
Hair Follicle Development

ABSTRACT Hair follicle morphogenesis depends on a delicate balance between cell proliferation and apoptosis, which involves epithelium-mesenchyme interactions. We show that peroxisome proliferator-activated receptor beta/delta (PPARβ/δ) and Akt1 are highly expressed in follicular keratinocytes throughout hair follicle development. Interestingly, PPARβ/δ- and Akt1-deficient mice exhibit similar retardation of postnatal hair follicle morphogenesis, particularly at the hair peg stage, revealing a new important function for both factors in the growth of early hair follicles. We demonstrate that a time-regulated activation of the PPARβ/δ protein in follicular keratinocytes involves the up-regulation of the cyclooxygenase 2 enzyme by a mesenchymal paracrine factor, the hepatocyte growth factor. Subsequent PPARβ/δ-mediated temporal activation of the antiapoptotic Akt1 pathway in vivo protects keratinocytes from hair pegs against apoptosis, which is required for normal hair follicle development. Together, these results demonstrate that epithelium-mesenchyme interactions in the skin regulate the activity of PPARβ/δ during hair follicle development via the control of ligand production and provide important new insights into the molecular biology of hair growth.

scholarly journals Hair Follicle Development and Hair Growth from Defined Cell Populations Grafted onto Nude Mice

1995 ◽  
Vol 104 (5) ◽  
pp. 43-44 ◽  
Author(s):  
Ulrike Lichti ◽  
Aline B. Scandurro ◽  
Tonja Kartasova ◽  
Stuart H. Yuspa ◽  
Jeffrey S. Rubin ◽  
...  
Keyword(s):  
Hair Follicle ◽  
Nude Mice ◽  
Hair Growth ◽  
Cell Populations ◽  
Follicle Development ◽  
Hair Follicle Development

scholarly journals Targeted Disruption of the Protein Kinase SGK3/CISK Impairs Postnatal Hair Follicle Development

2004 ◽  
Vol 15 (9) ◽  
pp. 4278-4288 ◽  
Author(s):  
James A. McCormick ◽  
Yuxi Feng ◽  
Kevin Dawson ◽  
Martin J. Behne ◽  
Benjamin Yu ◽  
...  
Keyword(s):  
Hair Follicle ◽  
Gene Transcription ◽  
Cultured Cells ◽  
Nuclear Accumulation ◽  
Follicle Development ◽  
Phosphatidylinositol 3 Kinase ◽  
Targeted Disruption ◽  
Hair Follicle Development ◽  
Close Relatives

Members of the serum- and glucocorticoid-regulated kinase (SGK) family are important mediators of growth factor and hormone signaling that, like their close relatives in the Akt family, are regulated by lipid products of phosphatidylinositol-3-kinase. SGK3 has been implicated in the control of cell survival and regulation of ion channel activity in cultured cells. To begin to dissect the in vivo functions of SGK3, we generated and characterized Sgk3 null mice. These mice are viable and fertile, and in contrast to mice lacking SGK1 or Akt2, respectively, display normal sodium handling and glucose tolerance. However, although normal at birth, by postpartum day 4 they have begun to display an unexpected defect in hair follicle morphogenesis. The abnormality in hair follicle development is preceded by a defect in proliferation and nuclear accumulation of β-catenin in hair bulb keratinocytes. Furthermore, in cultured keratinocytes, heterologous expression of SGK3 potently modulates activation of β-catenin/Lef-1–mediated gene transcription. These data establish a role for SGK3 in normal postnatal hair follicle development, possibly involving effects on β-catenin/Lef-1–mediated gene transcription.

The Nude Mouse Skin Phenotype: The Role of Foxn1 in Hair Follicle Development and Cycling

2001 ◽  
Vol 71 (2) ◽  
pp. 171-178 ◽  
Author(s):  
Lars Mecklenburg ◽  
Motonobu Nakamura ◽  
John P. Sundberg ◽  
Ralf Paus
Keyword(s):  
Hair Follicle ◽  
Nude Mouse ◽  
Mouse Skin ◽  
Follicle Development ◽  
Hair Follicle Development

scholarly journals Using WGCNA (weighted gene co-expression network analysis) to identify the hub genes of skin hair follicle development in fetus stage of Inner Mongolia cashmere goat

PLoS ONE ◽  
2020 ◽  
Vol 15 (12) ◽  
pp. e0243507
Author(s):  
Zhihong Wu ◽  
Erhan Hai ◽  
Zhengyang Di ◽  
Rong Ma ◽  
Fangzheng Shang ◽  
...  
Keyword(s):  
Network Analysis ◽  
Hair Follicle ◽  
Quantitative Polymerase Chain Reaction ◽  
Correlation Coefficients ◽  
Hair Follicles ◽  
Functional Enrichment ◽  
Follicle Development ◽  
Hub Genes ◽  
Cashmere Goats ◽  
Hair Follicle Development

Objective Mature hair follicles represent an important stage of hair follicle development, which determines the stability of hair follicle structure and its ability to enter the hair cycle. Here, we used weighted gene co-expression network analysis (WGCNA) to identify hub genes of mature skin and hair follicles in Inner Mongolian cashmere goats. Methods We used transcriptome sequencing data for the skin of Inner Mongolian cashmere goats from fetal days 45–135 days, and divided the co expressed genes into different modules by WGCNA. Characteristic values were used to screen out modules that were highly expressed in mature skin follicles. Module hub genes were then selected based on the correlation coefficients between the gene and module eigenvalue, gene connectivity, and Gene Ontology (GO)/Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis. The results were confirmed by quantitative polymerase chain reaction (qPCR). Results Ten modules were successfully defined, of which one, with a total of 3166 genes, was selected as a specific module through sample and gene expression pattern analyses. A total of 584 candidate hub genes in the module were screened by the correlation coefficients between the genes and module eigenvalue and gene connectivity. Finally, GO/KEGG functional enrichment analyses detected WNT10A as a key gene in the development and maturation of skin hair follicles in fetal Inner Mongolian cashmere goats. qPCR showed that the expression trends of 13 genes from seven fetal skin samples were consistent with the sequencing results, indicating that the sequencing results were reliable.n

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