Specific substance of Maruyama (SSM) suppresses immune responses in atopic dermatitis-like skin lesions in DS-Nh mice by modulating dendritic cell functions

There are presented modern data describing the current understanding of the pathogenesis of atopic dermatitis (AD): a genetic predisposition to atopy, disruptions of epidermal barrier integrity and a cascade of immune responses, contributing allergic inflammation in the skin. There are both described several mechanisms of acute and chronic phases of AD, the main directions of pathogenetically substantiated treatment of AD in children and indicated the prospects of new preparations specific blockers of proinflammatory cytokines involved in the development of AD - crisaborole, apremilast, dupilumab, lebrikizumab, tralokinumab, tezepelumab. There is especially presented in details external therapy of atopic skin lesions in children with the use of means of modern dermatological cosmetics.

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Effect of IFN-A on immune responses and plasmacytoid dendritic cell functions of patients with hepatitis B

Biomedical Research ◽

10.4066/biomedicalresearch.29-17-3861 ◽

2018 ◽

Vol 29 (6) ◽

Author(s):

Yue Chen ◽

Jiaen Yang ◽

Jingmo Tang ◽

Qianguo Mao ◽

Qizhong Zheng ◽

...

Keyword(s):

Dendritic Cell ◽

Hepatitis B ◽

Immune Responses ◽

Plasmacytoid Dendritic Cell ◽

Cell Functions

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CURRENT CONCEPTS OF ATOPIC DERMATITIS IN CHILDREN: PROBLEMS AND PROSPECTS

Rossiiskii Allergologicheskii ZHurnal ◽

10.36691/rja292 ◽

2017 ◽

Vol 14 (4-5) ◽

pp. 30-39

Author(s):

G I Smirnova

Keyword(s):

Atopic Dermatitis ◽

Immune Responses ◽

Proinflammatory Cytokines ◽

Genetic Predisposition ◽

Allergic Inflammation ◽

Skin Lesions ◽

Current Understanding ◽

Intestinal Microbiome ◽

Barrier Integrity ◽

Atopic Skin

Modern data describing the current understanding of the pathogenesis of atopic dermatitis (AD): a genetic predisposition to atopy, disturbances of the intestinal microbiome, disruptions of epidermal barrier integrity and a cascade of immune responses, contributing allergic inflammation in the skin are presented. There are both described several mechanisms of acute and chronic phases of AD, the main directions of pathogenetically substantiated treatment of AD in children and indicated the prospects of new preparations specific blockers of proinflammatory cytokines involved in the development of AD - crisaborole, dupilumab, apremilast et al. External therapy of atopic skin lesions in AD children with modern dermatological cosmetics is presented.

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Inhibitory effect of Platycodon grandiflorum on TH1 and TH2 immune responses in a murine model of 2,4-dinitrofluorobenzene–induced atopic dermatitis–like skin lesions

Annals of Allergy Asthma & Immunology ◽

10.1016/j.anai.2010.10.020 ◽

2011 ◽

Vol 106 (1) ◽

pp. 54-61 ◽

Cited By ~ 18

Author(s):

Min-Soo Kim ◽

Yun-Gyung Hur ◽

Wan-Gi Kim ◽

Byoung-Woo Park ◽

Kyoo-Seok Ahn ◽

...

Keyword(s):

Atopic Dermatitis ◽

Immune Responses ◽

Murine Model ◽

Skin Lesions ◽

Inhibitory Effect ◽

Platycodon Grandiflorum ◽

Th1 And Th2

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Pollen-Induced Oxidative Stress Influences Both Innate and Adaptive Immune Responses via Altering Dendritic Cell Functions

The Journal of Immunology ◽

10.4049/jimmunol.0803938 ◽

2010 ◽

Vol 184 (5) ◽

pp. 2377-2385 ◽

Cited By ~ 34

Author(s):

Aniko Csillag ◽

Istvan Boldogh ◽

Kitti Pazmandi ◽

Zoltan Magyarics ◽

Peter Gogolak ◽

...

Keyword(s):

Oxidative Stress ◽

Dendritic Cell ◽

Immune Responses ◽

Adaptive Immune Responses ◽

Cell Functions ◽

Adaptive Immune ◽

Stress Influences

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STING agonism enhances anti-tumor immune responses and therapeutic efficacy of PARP inhibition in BRCA-associated breast cancer

10.1101/2021.01.26.428337 ◽

2021 ◽

Author(s):

Constantia Pantelidou ◽

Heta Jadhav ◽

Aditi Kothari ◽

Renyan Liu ◽

Jennifer L. Guerriero ◽

...

Keyword(s):

Breast Cancer ◽

Dendritic Cell ◽

Immune Responses ◽

Antigen Processing ◽

Cell Activation ◽

Parp Inhibition ◽

Cytotoxic T Cell ◽

Breast Cancer Cell Lines ◽

Therapeutic Effects ◽

Cell Functions

ABSTRACTPoly (ADP-ribose) polymerase (PARP) inhibitors exert their efficacy by inducing synthetic lethal effects, as well as cGAS/STING-mediated immune responses in BRCA- and other homologous recombination repair-deficient cancer cells. Here we investigated whether the immunologic and therapeutic effects of PARP inhibition in BRCA-deficient breast cancer models could be augmented by synthetic cyclic dinucleotide agonists of STING. Combined PARP inhibition and STING agonism induced a greater degree of STING pathway activation and proinflammatory cytokine production compared to monotherapies in BRCA1-deficient human and mouse triplenegative breast cancer cell lines. In a mouse model of BRCA1-deficient TNBC, the combination also induced an improved immune response compared to either monotherapy alone, evidenced by a greater degree of cytotoxic T cell recruitment and activation, and enhanced dendritic cell activation and antigen presentation. Nanostring mRNA analysis indicated that combinatorial effects were the result of augmented interferon signaling and antigen processing, as well as of heightened leukocyte and dendritic cell functions. Finally, the combination markedly improved anti-tumor efficacy in vivo compared to monotherapy treatment, with evidence of complete tumor clearance and prolongation of survival. These results support the development of combined PARP inhibition and STING agonism in BRCA-associated breast cancer.

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Acupoint Autohemotherapy Attenuates DNCB-induced Atopic Dermatitis Lesions by Regulating Th1/Th2 Cytokine Balance in BALB/c Mice

10.21203/rs.3.rs-1081783/v1 ◽

2021 ◽

Author(s):

Zhiwen Zeng ◽

Jinquan Huang ◽

Yong Chen ◽

Xiao Yu ◽

Wei Zhu ◽

...

Keyword(s):

Atopic Dermatitis ◽

Immune Responses ◽

Immunohistochemical Analysis ◽

Skin Lesions ◽

Inhibitory Effect ◽

Serum Ige ◽

Cytokine Balance ◽

Autologous Whole Blood ◽

Similar Inhibitory Effect ◽

Ifn Γ

Abstract Objective Acupoint autohemotherapy (A-AHT) is considered an effective therapy for atopic dermatitis (AD) with few side-effects. Previous experiments showed the treatment had the potential to regulate T helper (Th) 1 and Th2 cytokines, like interferon (IFN)- gamma and interleukin (IL)- 4. This study focuses on the effects of A-AHT on the AD-like skin lesions through regulating Th1/Th2 immune responses. Methods The treatments of A-AHT, sham acupoint autohemotherapy and acupoint injection of normal saline were administered in the AD mice once every other day for 4 weeks. The total immunoglobulin (Ig) E, IL-4 and IFN-γ cytokine levels in the serum were examined after animal sacrifice. Th1/Th2 expression was analyzed in murine spleen cells via flow cytometry and immunohistochemical analysis of GATA-3 and T-bet in skin lesions were further assessed. Results Either type of repeated autologous whole blood (AWB) injection (into acupoint or sham acupoint) reduced the severity of AD-like symptoms and level of serum IgE. All of the three treatments had the similar inhibitory effect on levels of IL-4 and upregulation on the ratio of IFN-γ/IL-4, while differed on Th1/Th2 ratio as A-AHT regulates the body’s Th1/Th2 shift. This treatment also increased the related transcription factors T-bet expression, and upregulated T-bet/GATA3 ratio compared with the DNCB group. These differences were significant only in A-AHT group. Conclusion A-AHT effectively reduces AD symptoms and serum IgE levels in a mouse model and may act by regulating Th1/Th2 immune responses.

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Thymic stromal lymphopoietin: master switch for allergic inflammation

Journal of Experimental Medicine ◽

10.1084/jem.20051745 ◽

2006 ◽

Vol 203 (2) ◽

pp. 269-273 ◽

Cited By ~ 382

Author(s):

Yong-Jun Liu

Keyword(s):

Atopic Dermatitis ◽

Dendritic Cell ◽

Cell Activation ◽

Molecular Mechanisms ◽

Inflammatory Responses ◽

Allergic Inflammation ◽

Skin Lesions ◽

Thymic Stromal Lymphopoietin ◽

Dendritic Cell Activation

Thymic stromal lymphopoietin (TSLP) is an interleukin (IL) 7–like cytokine that triggers dendritic cell–mediated T helper (Th)2 inflammatory responses. TSLP is highly expressed by keratinocytes in skin lesions of patients with atopic dermatitis and is associated with dendritic cell activation in situ, suggesting that TSLP might be a master switch for allergic inflammation at the epithelial cell–dendritic cell interface. New reports now establish a direct link between TSLP expression and the pathogenesis of atopic dermatitis and asthma in vivo, and begin to reveal the molecular mechanisms underlying TSLP-induced allergic inflammation.

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