850nm light-emitting-diode phototherapy plus low-dose tacrolimus (FK-506) as combination therapy in the treatment of dermatophagoides farinae-induced atopic dermatitis-like skin lesions in NC/Nga mice

2013 ◽  
Vol 72 (2) ◽  
pp. 142-148 ◽  
Author(s):  
Chang-Hyun Kim ◽  
Kyung Ah Cheong ◽  
Ai-Young Lee
Keyword(s):  
Atopic Dermatitis ◽  
Combination Therapy ◽  
Low Dose ◽  
Light Emitting Diode ◽  
Skin Lesions ◽  
Dermatophagoides Farinae ◽  
Fk 506 ◽  
Light Emitting

scholarly journals Therapeutic Effects of a Light Emitting Diode at a Variety of Wavelengths on Atopic Dermatitis-Like Skin Lesions in NC/Nga Mice

2017 ◽  
Vol 29 (6) ◽  
pp. 796
Author(s):  
Eun Ah Cho ◽  
Ye Jin Lee ◽  
Yun Hee Ryu ◽  
Ju Hee Han ◽  
Ji Hyun Lee ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Light Emitting Diode ◽  
Skin Lesions ◽  
Therapeutic Effects ◽  
Light Emitting

Effects of low-dose light-emitting-diode therapy in combination with water bath for atopic dermatitis in NC/Nga mice

2015 ◽  
Vol 32 (1) ◽  
pp. 34-43 ◽  
Author(s):  
Chang-Hyun Kim ◽  
Kyung Ah Cheong ◽  
Won Suk Lim ◽  
Hyung-Moo Park ◽  
Ai-Young Lee
Keyword(s):  
Atopic Dermatitis ◽  
Low Dose ◽  
Light Emitting Diode ◽  
Water Bath ◽  
Light Emitting

scholarly journals Gomisin M2 Ameliorates Atopic Dermatitis-like Skin Lesions via Inhibition of STAT1 and NF-κB Activation in 2,4-Dinitrochlorobenzene/Dermatophagoides farinae Extract-Induced BALB/c Mice

Molecules ◽  
2021 ◽  
Vol 26 (15) ◽  
pp. 4409
Author(s):  
Jinjoo Kang ◽  
Soyoung Lee ◽  
Namkyung Kim ◽  
Hima Dhakal ◽  
Taeg-Kyu Kwon ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Oral Administration ◽  
Skin Diseases ◽  
Nuclear Translocation ◽  
Skin Lesions ◽  
Biologically Active ◽  
Therapeutic Effects ◽  
Dermatophagoides Farinae ◽  
Tnf Α ◽  
Ifn Γ

The extracts of Schisandra chinensis (Turcz.) Baill. (Schisandraceae) have various therapeutic effects, including inflammation and allergy. In this study, gomisin M2 (GM2) was isolated from S. chinensis and its beneficial effects were assessed against atopic dermatitis (AD). We evaluated the therapeutic effects of GM2 on 2,4-dinitrochlorobenzene (DNCB) and Dermatophagoides farinae extract (DFE)-induced AD-like skin lesions with BALB/c mice ears and within the tumor necrosis factor (TNF)-α and interferon (IFN)-γ-stimulated keratinocytes. The oral administration of GM2 resulted in reduced epidermal and dermal thickness, infiltration of tissue eosinophils, mast cells, and helper T cells in AD-like lesions. GM2 suppressed the expression of IL-1β, IL-4, IL-5, IL-6, IL-12a, and TSLP in ear tissue and the expression of IFN-γ, IL-4, and IL-17A in auricular lymph nodes. GM2 also inhibited STAT1 and NF-κB phosphorylation in DNCB/DFE-induced AD-like lesions. The oral administration of GM2 reduced levels of IgE (DFE-specific and total) and IgG2a in the mice sera, as well as protein levels of IL-4, IL-6, and TSLP in ear tissues. In TNF-α/IFN-γ-stimulated keratinocytes, GM2 significantly inhibited IL-1β, IL-6, CXCL8, and CCL22 through the suppression of STAT1 phosphorylation and the nuclear translocation of NF-κB. Taken together, these results indicate that GM2 is a biologically active compound that exhibits inhibitory effects on skin inflammation and suggests that GM2 might serve as a remedy in inflammatory skin diseases, specifically on AD.

scholarly journals Combination Therapy of Acarbose and Cyclosporine a Ameliorates Imiquimod-Induced Psoriasis-Like Dermatitis in Mice

Molecules ◽  
2020 ◽  
Vol 25 (8) ◽  
pp. 1822 ◽  
Author(s):  
Hsin-Hua Chen ◽  
Chi-Chien Lin ◽  
Yu-Tang Tung ◽  
Ya-Hsuan Chao ◽  
Wen-Ching Huang ◽  
...  
Keyword(s):  
Combination Therapy ◽  
Low Dose ◽  
Skin Lesions ◽  
Treg Cells ◽  
Psoriatic Skin ◽  
Th22 Cells ◽  
Immune Mediated ◽  
Cytokine Tumor Necrosis Factor ◽  
High Doses ◽  
Factor Α

Moderate to severe psoriasis, an immune-mediated inflammatory disease, adversely affects patients’ lives. Cyclosporin A (CsA), an effective immunomodulator, is used to treat psoriasis. CsA is ineffective at low doses and toxic at high doses. Acarbose (Acar), a common antidiabetic drug with anti-inflammatory and immunomodulatory effects, reduces imiquimod (IMQ)-induced psoriasis severity. Combinations of systemic drugs are generally more efficacious and safer than higher doses of single drugs. We observed that mice treated with a combination of Acar (250 mg/kg) and low-dose CsA (10 or 20 mg/kg) exhibited significantly milder IMQ-induced psoriasis-like dermatitis and smoother back skin than those treated with Acar (250 mg/kg), low-dose CsA (10 or 20 mg/kg), or IMQ alone. The combination therapy significantly reduced serum and skin levels of Th17-related cytokines (interleukin (IL)-17A, IL-22, and IL-23) and the Th1-related cytokine tumor necrosis factor-α (TNF-α) compared with Acar, low-dose CsA, and IMQ alone. Additionally, the combination therapy significantly reduced the percentages of IL-17- and IL-22-producing CD4+ T-cells (Th17 and Th22 cells, respectively) and increased that of Treg cells. Our data suggested that Acar and low-dose CsA in combination alleviates psoriatic skin lesions by inhibiting inflammation. The findings provide new insights into the effects of immunomodulatory drugs in psoriasis treatment.

scholarly journals Induction of atopic dermatitis by epicutaneous sensitisation with Dermatophagoides farinae in nongenetically predisposed Beagle dogs

2021 ◽  
Vol 66 (No. 10) ◽  
pp. 413-422
Author(s):  
Y Jeong ◽  
T Yun ◽  
H Kim ◽  
Y Koo ◽  
JH Kang ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Environmental Exposure ◽  
Inflammatory Cells ◽  
Skin Lesions ◽  
Specific Ige ◽  
Dermatophagoides Farinae ◽  
Beagle Dogs ◽  
Serum Samples ◽  
Skin Biopsies ◽  
Dermal Oedema

This study was performed to induce atopic dermatitis (AD) using nongenetically predisposed Beagle dogs. Five healthy Beagle dogs were used. Twice weekly for 12 weeks, the dogs were painted on the axillae and groin with a solution of Dermatophagoides farinae (D. farinae). Each dog was thereafter placed in a cage where a house dust mite (HDM) solution was applied on the bottom of the cage. The dog remained in the cage for 3 h daily for 3 consecutive days for the environmental exposure to HDM. Serum samples were collected at 0 week and 6 weeks after sensitisation, and at 0 h and 72 h after the environmental exposure. During the environmental exposure, skin biopsies were obtained at 0 h, 36 h, and 72 hours. After the first environmental exposure, no dog had any marked clinical sign. An additional sensitisation was subsequently administered for 10–13 weeks. Three of the five dogs developed pruritic dermatitis with skin lesions after the second exposure. The histopathology of the lesions revealed severe infiltration of inflammatory cells and dermal oedema. The levels of D. farinae-specific IgE were also elevated. This study demonstrated that AD could be induced by epicutaneous sensitisation with HDM in nongenetically predisposed dogs.

Sign in / Sign up

Export Citation Format

Share Document