Non-linear associations of risk factors with mild hypoglycemia among Chinese patients with type 2 diabetes

2016 ◽  
Vol 30 (3) ◽  
pp. 462-468 ◽  
Author(s):  
Weijun Gu ◽  
Yanfeng Ren ◽  
Linong Ji ◽  
Tianpei Hong ◽  
Yiming Mu ◽  
...  
Keyword(s):  
Risk Factors ◽  
Type 2 Diabetes ◽  
Chinese Patients ◽  
Non Linear

scholarly journals Prevalence and Risk Factors of Prolonged QTc Interval among Chinese Patients with Type 2 Diabetes

2012 ◽  
Vol 2012 ◽  
pp. 1-6 ◽  
Author(s):  
Xiang Li ◽  
Hui Ren ◽  
Zhang-rong Xu ◽  
Yan-jun Liu ◽  
Xiao-pin Yang ◽  
...  
Keyword(s):  
Risk Factors ◽  
Blood Pressure ◽  
Type 2 Diabetes ◽  
Waist Circumference ◽  
Qt Interval ◽  
Postprandial Glucose ◽  
Chinese Patients ◽  
Qtc Interval ◽  
Fasting Insulin

Objectives. The aim of this study was to evaluate the prevalence and the risk factors of prolonged QTc interval among Chinese patients with type 2 diabetes.Methods. The retrospective study included 3156 outpatients from the Diabetes Centre, the 306th Hospital of PLA, during the period from September 2003 to June 2010. QT interval was measured manually in the 12-lead conventional electrocardiogram. The QT interval corrected for heart rate (QTc) was calculated using Bazett’s formula. Additional demographic and laboratory data were also collected. Potential risk factors of prolonged QTc interval were assessed using multivariable regression.Results.The prevalence of prolonged QTc interval among Chinese patients with type 2 diabetes was 30.1%. Height (OR 0.156, 95% CI 0.032~0.748), waist circumference (OR 1.025, 95% CI 1.010~1.040), diastolic blood pressure (OR 1.016, 95% CI 1.007~1.026), postprandial glucose (OR 1.040, 95% CI 1.022~1.059), fasting insulin (OR 1.014, 95% CI 1.003~1.025), and presence of microalbuminuria (OR 1.266, 95% CI 1.033~1.551) were significant risk factors.Conclusions. The prevalence of prolonged QTc interval among Chinese patients with type 2 diabetes is high. Risk factors for prolongation of QTc interval were low height, high waist circumference, increasing diastolic blood pressure levels, high postprandial glucose levels, high fasting insulin levels, and presence of microalbuminuria.

scholarly journals Cumulative Effects of Hypertension, Dyslipidemia, and Chronic Kidney Disease on Carotid Atherosclerosis in Chinese Patients with Type 2 Diabetes Mellitus

2014 ◽  
Vol 2014 ◽  
pp. 1-7 ◽  
Author(s):  
Chuang Yuan ◽  
Christopher W. K. Lai ◽  
Lawrence W. C. Chan ◽  
Meyrick Chow ◽  
Helen K. W. Law ◽  
...  
Keyword(s):  
Risk Factors ◽  
Type 2 Diabetes ◽  
Odds Ratio ◽  
Carotid Plaque ◽  
Carotid Atherosclerosis ◽  
Chinese Patients ◽  
Plaque Score ◽  
Atherosclerosis Risk ◽  
Atherosclerosis Risk Factors

Aims. The aim of this study is to determine the extent of carotid atherosclerosis in Chinese patients with type 2 diabetes in relation to the cumulative atherosclerosis risk factors using ultrasonography.Methods.The presence of hypertension, dyslipidemia, and chronic kidney disease (CKD) was documented in 106 Chinese subjects with type 2 diabetes. Subjects with 0, 1, and ≥2 additional atherosclerosis risk factors were assigned into groups 1, 2, and 3, respectively (n=17, 49, and 40, resp.). Using ultrasound, the carotid arteries were assessed for the presence of carotid plaque, plaque score, intima-media thickness (IMT), and carotid arterial stiffness.Results.With the adjustment for age and gender, the presence of plaque and plaque score were significantly higher in groups with more atherosclerosis risk factors (P<0.05). In addition, age > 60 years old (odds ratio = 2.75; 95% CI: 1.26–6.0) and the presence of hypertension (odds ratio = 2.48; 95% CI: 1.11–5.58), dyslipidemia (odds ratio = 2.41; 95% CI: 1.05–5.51), and CKD (odds ratio = 7.80; 95% CI: 1.46–41.72) could independently predict higher plaque score (P<0.05).Conclusions.Hypertension, dyslipidemia, and CKD in Chinese patients with type 2 diabetes have cumulative effects on the burden of carotid plaque.

scholarly journals Association of diabetic retinopathy and diabetic macular oedema with renal function in southern Chinese patients with type 2 diabetes mellitus: a single-centre observational study

BMJ Open ◽  
2019 ◽  
Vol 9 (9) ◽  
pp. e031194 ◽  
Author(s):  
Xuenan Zhuang ◽  
Dan Cao ◽  
Dawei Yang ◽  
Yunkao Zeng ◽  
Honghua Yu ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Renal Function ◽  
Diabetic Macular Oedema ◽  
Chinese Patients ◽  
Single Centre ◽  
Southern Chinese

Background and objectivesThe association of diabetic retinopathy (DR) and diabetic macular oedema (DME) with renal function in southern Chinese patients with diabetes is poorly understood. So we aimed to study the correlation between stage of DR and DME with stage of estimated glomerular filtration rate (eGFR) and stage of urine albumin-to-creatinine ratio (UACR), and to explore the systemic risk factors for DR and DME.Design and settingThis single-centre retrospective observational study was conducted from December 2017 to November 2018.Participants413 southern Chinese patients with type 2 diabetes mellitus.Outcome measuresThe correlations between stage of DR and DME with stage of eGFR/UACR were assessed by Spearman’s or χ² analyses and represented with histograms. Risk factors associated with the occurrence of DR and DME were performed by logistic regression and represented with nomograms.ResultsStage of DR had a positive correlation with stage of eGFR (r=0.264, p<0.001) and stage of UACR (r=0.542, p<0.001). With the stage of eGFR/UACR being more severe, the prevalence of DME became higher as well (both p<0.001). The risk factors for DR were DM duration (OR 1.072; 95% CI 1.032 to 1.114; p<0.001), stage of UACR (OR 2.001; 95% CI 1.567 to 2.555; p<0.001) and low-density lipoprotein (LDL) (OR 1.301; 95% CI 1.139 to 1.485; p<0.001), while risk factors for DME were stage of UACR (OR 2.308; 95% CI 1.815 to 2.934; p<0.001) and LDL (OR 1.460; 95% CI 1.123 to 1.875; p=0.008).ConclusionsAmong southern Chinese patients, stage of DR and DME were positively correlated with renal function, while stage of UACR performed a better relevance than stage of eGFR.

scholarly journals Solidified glomerulosclerosis, identified using single glomerular proteomics, predicts end-stage renal disease in Chinese patients with type 2 diabetes

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Lijun Zhao ◽  
Fang Liu ◽  
Lin Li ◽  
Junlin Zhang ◽  
Tingli Wang ◽  
...  
Keyword(s):  
Risk Factors ◽  
Type 2 Diabetes ◽  
Renal Disease ◽  
End Stage Renal Disease ◽  
Chinese Patients ◽  
Prognostic Indicators ◽  
Diabetic Patients ◽  
Stage Renal Disease ◽  
End Stage

AbstractFew histological prognostic indicators for end-stage renal disease (ESRD) have been validated in diabetic patients. This biopsy-based study aimed to identify nephropathological risk factors for ESRD in Chinese patients with type 2 diabetes. Histological features of 322 Chinese type 2 diabetic patients with biopsy-confirmed diabetic nephropathy (DN) were retrospectively analysed. Cox proportional hazards analysis was used to estimate the hazard ratio (HR) for ESRD. Single glomerular proteomics and immunohistochemistry were used to identify differentially expressed proteins and enriched pathways in glomeruli. During the median follow-up period of 24 months, 144 (45%) patients progressed to ESRD. In multivariable models, the Renal Pathology Society classification failed to predict ESRD, although the solidified glomerulosclerosis (score 1: HR 1.65, 95% confidence interval [CI] 1.04–2.60; score 2: HR 2.48, 95% CI 1.40–4.37) and extracapillary hypercellularity (HR 2.68, 95% CI 1.55–4.62) were identified as independent risk factors. Additionally, single glomerular proteomics, combined with immunohistochemistry, revealed that complement C9 and apolipoprotein E were highly expressed in solidified glomerulosclerosis. Therefore, solidified glomerulosclerosis and extracapillary hypercellularity predict diabetic ESRD in Chinese patients. Single glomerular proteomics identified solidified glomerulosclerosis as a unique pathological change that may be associated with complement overactivation and abnormal lipid metabolism.

scholarly journals Patient characteristics of hypoglycemia in type 2 diabetes mellitus in China: a retrospective cohort study and data analysis

2019 ◽  
Author(s):  
yongwen zhang ◽  
Huanhuan Han ◽  
Lanfang Chu
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Cognitive Impairment ◽  
Retrospective Cohort ◽  
Severe Hypoglycemia ◽  
Patient Characteristics ◽  
Chinese Patients

Abstract Background: The goals of the present study were to quantify incidence rate of hypoglycemia, in-vestigate risk factors for hypoglycemia in patients with type 2 diabetes mellitus (T2DM) and suggest preventive measures. Methods: This study was a retrospective cohort, multicenter, non-interventional study of hypogly-cemic events, used previously acquired data from 10,359 patients with T2DM, who were treated between March 2015 and March 2018. Two aspects of our research were investigated: (i) retrospec-tive study to assess the incidence of hypoglycemia during hospitalization; and (ii) to determine the relationship between hypoglycemia and risk factors such as age, HbA1c, complications, duration of DM, insulin and/or SU use, and cognitive impairment. Results: Overall, 9,993 patients were included in the full analysis set, 376 patients were identified hypoglycemia in the database. Demographic characteristics of patients with T2DM were similar between hypoglycemia and non-hypoglycemia groups, significant differences were not observed between the groups, except for cognitive impairment (p =0.037). The most common cause of hypo-glycemia was drug overdose/misuse (34.2%), irregular diet (21.3%), and excessive physical activity (13.8%). Most of the hypoglycemic episodes occurred before and after lunch (39.4% between 10:00 and 13:00). Retrospective rates (events per patient per month [PPPM]) of overall, severe, and noc-turnal hypoglycemia were 3.83 events PPPM (95% CI 1.90–5.80), 1.17 events PPPM (95% CI 0.78-1.56), and 0.07 events PPPM (95% CI 0.05-0.09). Multivariate model analysis showed that the use of SU (OR=3.162, p = 0.040) and insulin (OR= 2.414, p = 0.017) were associated with hypo-glycemic events. Logistic regression analysis of the variables revealed that significant positive as-sociation of the frequency of overall and severe hypoglycemia with age (beta=0.855, p=0.018; be-ta=1.343, p=0.015) and duration of DM (beta=1.248, p=0.025; beta=0.947, p=0.014). Conclusions: The present study shows that advanced age, duration of DM, cognitive dysfunction, and insulin and/or SU use are the main causes of hypoglycemia in Chinese patients with T2DM. Education on hypoglycemia, appropriate use of antidiabetic drugs and avoidance of related risk factors are essential for patients with DM.

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