H. pylori seroprevalence and risk of diabetes: An ancillary case–control study nested in the diabetes prevention program

Background and Aims.Hepatocellular carcinoma is a major cause of cancer death worldwide, accounting for over half a million deaths per year. Its incidence varies with geographic locations and the type of etiologic factors. In Ethiopia, unidentified causes of liver disease are of sizeable proportion. Recent studies have shown an association of H. pylori infection with different spectrums of chronic liver disease. This study was conducted at St. Paul’s Hospital Millennium Medical College in Ethiopia and assesses liver cancer and the association with H. pylori infection.Method.A prospective case-control study conducted on patients with chronic liver disease presenting with a suspicious liver lesion and diagnosed to have HCC in the Gastrointestinal (GI) Clinic of St. Paul’s Hospital MMC from Dec 30, 2016, to Nov 1, 2017 G.C. Descriptive surveys on clinical history and physical examination and laboratory profiles were obtained, and the clinical course of the patients including the type of treatment was followed prospectively. Control cases were taken from adult patients without evidence of liver disease in the internal medicine clinic coming for routine evaluation. After collection data were analyzed using SPSS version 23 and associations were assessed using chi-square test. Binary logistic regression was used to assess the association of HCC with different variables and H. pylori infection. All variables with p-value <0.05 were considered as statistically significant.Results.One hundred twenty patients were analyzed with equal representation of cases and controls. The majority of patients with HCC were male with a mean age of 36 years. Older age adjusted Odds Ratio (AOR) (95%CI, p-value) 1.07(1.03-1.09, <0.001), viral hepatitis B (AOR) (95%CI, p-value) 6.19 (1.92-19.93, 0.002), and H. pylori infection (AOR) (95%CI, p-value) 5.22 (2.04–13.31, <0.001) were statistically significantly associated with HCC.Conclusion.H. pylori infection is associated with HCC in this case-control study. This study supports the emerging evidence of H. pylori association with other extra-gastric manifestations.

Download Full-text

A Case-Control Study of an Intraoperative Corneal Abrasion Prevention Program: Holding the Gains Made with a Continuous Quality Improvement Effort

The Joint Commission Journal on Quality and Patient Safety ◽

10.1016/s1553-7250(12)38065-3 ◽

2012 ◽

Vol 38 (11) ◽

pp. 490-AP1 ◽

Cited By ~ 5

Author(s):

Thomas R. Vetter ◽

Nabil M.K. Ali ◽

Arthur M. Boudreaux

Keyword(s):

Quality Improvement ◽

Continuous Quality Improvement ◽

Prevention Program ◽

Case Control Study ◽

Case Control ◽

Quality Improvement Effort ◽

Corneal Abrasion ◽

Continuous Quality ◽

Improvement Effort ◽

Control Study

Download Full-text

Peptic ulcer bleeding in the elderly: relative roles ofHelicobacter pylori and non-steroidal anti-inflammatory drugs

Gut ◽

10.1136/gut.41.4.459 ◽

1997 ◽

Vol 41 (4) ◽

pp. 459-462 ◽

Cited By ~ 94

Author(s):

D J E Cullen ◽

G M Hawkey ◽

D C Greenwood ◽

H Humphreys ◽

V Shepherd ◽

...

Keyword(s):

Case Control Study ◽

The Elderly ◽

Case Control ◽

Ulcer Bleeding ◽

Peptic Ulcer Bleeding ◽

Increased Risk ◽

Inflammatory Drugs ◽

Anti Inflammatory ◽

H Pylori ◽

Control Study

Background—Most ulcers are caused, one can deduce, by Helicobcter pylori or by use of non-steroidal anti-inflammatory drugs (NSAIDs). Whether both together are worse than one alone is something that is quite unknown.Aim—To study both factors in order to see whether they interact together positively.Method—A case control study of ulcer bleeding in elderly patients chosen without weeding.Results—NSAID usage increased risk substantially. So did H pylori infection (but relative risk less than three). Neither seemed to interact. Their actions were discretely intact.Conclusion—H pylori effects ulcer bleeding in an adverse manner but does not make the risk of NSAIDs worse.

Download Full-text

The Association between dietary total antioxidant capacity with the risk of helicobacter pylori infection among adult: a case–control study

10.21203/rs.3.rs-26614/v1 ◽

2020 ◽

Author(s):

Mohammadhassan Sohouli ◽

Niloufar Haghshenas ◽

Somaye Fatahi

Keyword(s):

Helicobacter Pylori ◽

Antioxidant Capacity ◽

Total Antioxidant Capacity ◽

Case Control Study ◽

Case Control ◽

Antioxidant Power ◽

Total Antioxidant ◽

H Pylori ◽

Control Study ◽

Dietary Total Antioxidant Capacity

Abstract Background Dietary total antioxidant capacity (DTAC) has been assumed as a useful tool to assess the relationship between the cumulative antioxidant food capacity and several chronic disorders. The aim of this study was to evaluate the association between DTAC and risk of Helicobacter pylori in a case-control study.Methods This case-control study was carried out among 150 patients with Helicobacter pylori and 302 healthy subjects aged 18–55 years. Dietary data were collected using a validated 168- items quantitative food frequency questionnaire. DTAC was calculated based on the ferric reducing-antioxidant power (FRAP) values that reported by US Department of Agriculture. Results The mean age and BMI of the study participants were 38.70 years and 25.86, respectively. Compared with control subjects, participants with H pylori significantly were older and had higher BMI and smoking use. Patients with H pylori compared with control individuals had also lower intake of total fiber, vitamin E, vitamin C, vitamin D, total dairy, whole grain and vegetables. Compared with participants in the lowest tertile of DTAC, those in the highest terrtile had a significantly lower OR for H pylori after further adjustment for potential confounders (Model 2: OR, 0.20; 95% CI, 0.10 – 0.40; P for trend, < 0.001).Conclusions Our findings showed that a high DTAC was associated with a reduced risk of Helicobacter pylori in adult, which reflects the increased intake of natural dietary antioxidants to prevent the progression of Helicobacter pylori. However, further studies are needed to investigate the t relation between DTAC and risk of Helicobacter pylori.

Download Full-text

Helicobacter Pylori Eradication Therapy is Not Associated with the Onset of Inflammatory Bowel Diseases. A Case-Control Study

Journal of Gastrointestinal and Liver Diseases ◽

10.15403/jgld.2014.1121.272.hpy ◽

2018 ◽

Vol 27 (2) ◽

pp. 119-125 ◽

Cited By ~ 3

Author(s):

Rosa Rosania ◽

Ulrike Von Arnim ◽

Alexander Link ◽

Mirjana Rajilic-Stojanovic ◽

Caspar Franck ◽

...

Keyword(s):

Case Control Study ◽

Case Reports ◽

Eradication Therapy ◽

Case Control ◽

Control Group ◽

Serum Samples ◽

Bowel Diseases ◽

Inflammatory Bowel ◽

H Pylori ◽

Control Study

Background & Aims: A negative association between H. pylori and inflammatory bowel disease (IBD) has been previously reported. There were also case reports suggesting a new onset of IBD 6-12 months after H. pylori eradication therapy. In a case-control study we investigated whether previous H. pylori eradication therapy was associated with the risk of developing IBD.Methods: IBD outpatients with both Crohn´s disease (CD) and ulcerative colitis (UC) were enrolled. Age- and sex-matched blood donors served as controls in a 1:2 fashion. Information on demographics, medical history, previous H. pylori infection and eradication therapy was recorded. Serum samples for H. pylori serology testing (anti-H. pylori-IgG and anti-CagA-IgG) were obtained. Controls that received H. pylori eradication therapy during the 12 months previous to enrollment were excluded.Results: Overall, 127 IBD patients (CD N= 90; UC N= 37) and 254 controls were enrolled. The prevalence of H. pylori infection (positive H. pylori serology and/or previous eradication) in IBD patients and controls was 11% and 23%, respectively (OR 0.4, 95% CI 0.21-0.74, p<0.003). Four patients (3%) developed IBD (3 MC and 1 CU) after receiving successful H. pylori eradication (latency 6-12 months). The rate of previous H. pylori eradication therapy in patents who successively developed IBD was lower but not statistically different from that observed in the control group (OR 0.43, 95% CI 0.14-1.29, p=0.16).Conclusions: In our study previous H. pylori eradication therapy was not associated with the onset of IBD.Whether in a subgroup of patients, H. pylori eradication therapy may trigger a latent IBD, cannot be excluded.

Download Full-text

Helicobacter pylori infection among type 2 diabetics: a case control study

International Journal of Research in Medical Sciences ◽

10.18203/2320-6012.ijrms20200779 ◽

2020 ◽

Vol 8 (3) ◽

pp. 1047

Author(s):

Hafiz Qazi Muhammad Amir ◽

Omaila Ikram ◽

Muhammad Tayyab Zia ◽

Fareha Kashan Theba ◽

Naila Ikram ◽

...

Keyword(s):

Helicobacter Pylori ◽

Case Control Study ◽

Case Control ◽

Helicobacter Pylori Infection ◽

P Value ◽

Type 2 Diabetics ◽

Dyspeptic Symptoms ◽

H Pylori ◽

Control Study

Background: Helicobacter pylori infection has been associated with hyperglycemia among type 2 diabetics. The objective of this study was to compare the H. pylori infection frequency in diabetic and non-diabetic patients.Methods: This case-control study was done at Al-Tibri Medical College and Hospital from May 2019 to August 2019. After written and informed consent, patients between 18-75 years with epigastric burning, dyspepsia, regurgitation were included and with history of eradication therapy, antibiotic or NSAID use in the last 6 months or surgery of upper GI tract months were excluded. Type 2 diabetics were placed in one group and non-diabetic individuals in another. Both groups were compared for presence of H. pylori infection. Data was analysed using SPSS. Demographic variables included age, gender and status of H. pylori infection. Quantitative data was expressed as frequency and percentages. Chi-square test was applied to test for significance keeping p-value of <0.05 statistically significant.Results: From 480 patients, 355 patients showed positive H. pylori, among them 282 were diabetic and 73 non-diabetic (p-value <0.001). Amongst the 355 diabetics, 55% were male Among 73 non-diabetics, 64% were male. All the patients in the study had dyspeptic symptoms and complained of dyspepsia, epigastric burning and regurgitation.Conclusions: A substantial relationship between H. pylori infection among type 2 diabetes mellitus patients was observed compared to non-diabetics. As a result, diabetic patients having active dyspeptic symptoms should undergo further confirmatory tests for diagnosing H. pylori infection.

Download Full-text

The Association between dietary total antioxidant capacity with the risk of helicobacter pylori infection among adult: a case–control study

10.21203/rs.3.rs-26732/v1 ◽

2020 ◽

Author(s):

Mohammadhassan Sohouli ◽

Niloufar Haghshenas ◽

Somaye Fatahi

Keyword(s):

Helicobacter Pylori ◽

Antioxidant Capacity ◽

Total Antioxidant Capacity ◽

Case Control Study ◽

Case Control ◽

Antioxidant Power ◽

Total Antioxidant ◽

H Pylori ◽

Control Study ◽

Dietary Total Antioxidant Capacity

Abstract Objective Dietary total antioxidant capacity (TAC) has been assumed as a useful tool to assess the relationship between the cumulative antioxidant food capacity and several chronic disorders. The aim of this study was to evaluate the association between DTAC and risk of Helicobacter pylori in a case-control study. Methods This case-control study was carried out among 150 patients with Helicobacter pylori and 302 healthy subjects aged 18–55 years. Dietary data were collected using a validated 168- items quantitative food frequency questionnaire. DTAC was calculated based on the ferric reducing-antioxidant power (FRAP) values that reported by US Department of Agriculture. Results The mean age and BMI of the study participants were 38.70 years and 25.86, respectively. Compared with control subjects, participants with H pylori significantly were older and had higher BMI and smoking use. Patients with H pylori compared with control individuals had also lower intake of total fiber, vitamin E, vitamin C, vitamin D, total dairy, whole grain and vegetables. Compared with participants in the lowest tertile of DTAC, those in the highest terrtile had a significantly lower OR for H pylori after further adjustment for potential confounders (Model 2: OR, 0.20; 95% CI, 0.10–0.40; P for trend, < 0.001). Conclusions Our findings showed that a high DTAC was associated with a reduced risk of Helicobacter pylori in adult, which reflects the increased intake of natural dietary antioxidants to prevent the progression of Helicobacter pylori. However, further studies are needed to investigate the t relation between DTAC and risk of Helicobacter pylori.

Download Full-text