Increased epicardial fat tissue thickness predicts advanced interatrial block among hypertensive patients

Abstract Aim To study the influence of epicardial fat tissue (EFT) on atrial fibrillation (AF) occurrence in hypertensive patients. Materials and methods The study included 195 patients with hypertension aged from 38 to 72 years (mean age was 61.5±1.8 years). All patients were divided into two groups: group I included 95 hypertensive patients with paroxysmal AF; 100 patients with hypertension in sinus rhythm were enrolled into group II. Echocardiography was performed to evaluate the thickness of EFT in a parasternal long-axis view. The EFT volume was assessed with computed tomography (CT) scan. The plasma concentration of tissue inhibitor of metalloproteinase-1 (TIMP-1) and metalloproteinase-9 (MMP-9) was measured to evaluate the myocardial fibrosis process. Results There was no significant difference between the studied groups of patients in body mass index: 34.43±1.2 kg/m2 in group I vs 31.97±1.67 kg/m2 in the group II. Waist circumference was significantly higher in group I in comparison with the group II patients: 118.9±3.3 cm vs 110.2±1.4 cm, respectively (p=0.038). EFT thickness was significantly higher in patients with paroxysmal AF (11.6±0.8 mm) in comparison with the patients in sinus rhythm (8.6±0.4 mm) (p<0.001). In group I patients a significant increase of EFT volume (4.6±0.4) in comparison with II group (3.5±0.25) (p=0.002) was noted. A significant positive correlation was revealed in hypertensive patients with paroxysmal AF between EFT volume and left atrial (LA) volume (r=0.7, p=0.022). Also, the plasma concentrations of TIMP-1 and MMP-1 were significantly higher in patients with paroxysmal AF and hypertension. There was a strong positive correlation between EFT volume and plasma concentration of TIMP-1 (r=0.72; p=0.01) and between the EFT volume and the LA volume (r=0.7, p=0.022) in group I patients. Multivariate regression analysis revealed the significant influence of increased EFT thickness more than 10 mm (prevalence ratio (PR) 4.1; 95% CI 1.1; 15.6) and EFT volume more than 6 ml (PR 3.7; 95% CI 1.0; 14.2) on AF occurrence. Conclusion Increased EFT thickness (more than 10 mm) and EFT volume (more than 6 ml) are predictors of AF onset in hypertensive patients. Funding Acknowledgement Type of funding source: Public Institution(s). Main funding source(s): The complex subject of the Department

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The relation between epicardial fat tissue thickness and atrial fibrillation ın hemodialysis patients

Seminars in Dialysis ◽

10.1111/sdi.12901 ◽

2020 ◽

Vol 33 (5) ◽

pp. 428-434

Author(s):

Fatma Betül Guzel ◽

Orcun Altunoren ◽

Hakan Gunes ◽

Muhammed Seyithanoglu ◽

Murat Kerkutluoglu ◽

...

Keyword(s):

Atrial Fibrillation ◽

Hemodialysis Patients ◽

Epicardial Fat ◽

Fat Tissue ◽

Tissue Thickness ◽

Epicardial Fat Tissue

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Is there a relationship between serum paraoxonase level and epicardial fat tissue thickness?

Anadolu Kardiyoloji Dergisi/The Anatolian Journal of Cardiology ◽

10.5152/akd.2014.4742 ◽

2014 ◽

Vol 14 (2) ◽

pp. 115-120 ◽

Cited By ~ 1

Author(s):

Ahmet Goktug Ertem ◽

Ali Erayman ◽

Tolga Han Efe ◽

Bilge Duran Karaduman ◽

Halil Ibrahim Aydin ◽

...

Keyword(s):

Epicardial Fat ◽

Fat Tissue ◽

Tissue Thickness ◽

Epicardial Fat Tissue ◽

Serum Paraoxonase

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Evaluation of epicardial fat tissue thickness and aortic stiffness in patients with gestational diabetes mellitus

Perinatal Journal ◽

10.2399/prn.21.0291006 ◽

2021 ◽

Vol 29 (1) ◽

pp. 33-38

Author(s):

Melike Nur Akın ◽

Burcu Kasap ◽

Fatih Akın ◽

Burak Sezgin ◽

İbrahim Altun ◽

...

Keyword(s):

Diabetes Mellitus ◽

Gestational Diabetes ◽

Gestational Diabetes Mellitus ◽

Pregnant Women ◽

Aortic Stiffness ◽

Epicardial Fat ◽

Control Group ◽

Fat Tissue ◽

Tissue Thickness ◽

Epicardial Fat Tissue

Objective We aimed to assess the relationship between gestational diabetes mellitus and coronary artery disease by measuring epicardial fat tissue thickness and aortic stiffness in pregnant women diagnosed with gestational diabetes mellitus. Methods 28 pregnant women diagnosed with gestational diabetes mellitus and 25 pregnant women without gestational diabetes mellitus were included in the research. Body mass index, laboratory values, blood pressure measurements and obstetric history findings of the study population were recorded. All participants of the study population were evaluated with transthoracic echocardiography between 24 and 28 weeks of gestational period. The measurement of epicardial fat tissue thickness was taken and aortic stiffness index was also calculated. Results The age, gravidity, parity and obstetric history of the two groups were similar. Epicardial fat tissue thickness was found significantly higher in gestational diabetes mellitus group than control group (0.416 cm and 0.336 cm, respectively; p<0.001). However, no significant difference was found in aortic stiffness measurements of the two groups (p=0.079). Conclusion According to the results of our study, epicardial fat tissue thickness was found to be statistically significantly higher in pregnant women with gestational diabetes mellitus compared to the control group. The fact that no difference was detected in other cardiovascular parameters suggests that measurement of epicardial fat tissue thickness in gestational period may be a beneficial adjunctive tool in early detection of gestational diabetes mellitus.

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