An integrated strategy based on UPLC–DAD–QTOF-MS for metabolism and pharmacokinetic studies of herbal medicines: Tibetan “Snow Lotus” herb (Saussurea laniceps), a case study

2014 ◽  
Vol 153 (3) ◽  
pp. 701-713 ◽  
Author(s):  
Tao Yi ◽  
Lin Zhu ◽  
Yi-Na Tang ◽  
Jian-Ye Zhang ◽  
Zhi-Tao Liang ◽  
...  
Keyword(s):  
Herbal Medicines ◽  
Pharmacokinetic Studies ◽  
Integrated Strategy ◽  
Saussurea Laniceps ◽  
Snow Lotus

scholarly journals Verticillium wilt of olive: a case study to implement an integrated strategy to control a soil-borne pathogen

2010 ◽  
Vol 344 (1-2) ◽  
pp. 1-50 ◽  
Author(s):  
Francisco Javier López-Escudero ◽  
Jesús Mercado-Blanco
Keyword(s):  
Verticillium Wilt ◽  
Integrated Strategy

scholarly journals Literature based discovery of alternative TCM medicine for adverse reactions to depression drugs

2020 ◽  
Vol 21 (S5) ◽  
Author(s):  
Qing Xie ◽  
Kyoung Min Yang ◽  
Go Eun Heo ◽  
Min Song
Keyword(s):  
Side Effects ◽  
Herbal Medicines ◽  
Interaction Network ◽  
Enrichment Analysis ◽  
New Drugs ◽  
Protein Protein Interaction ◽  
Target Drug ◽  
Target Disease ◽  
Literature Based Discovery

Abstract Background In recent years, Traditional Chinese Medicine (TCM) and alternative medicine have been widely used along with western drugs as a complementary form of treatment. In this study, we first use the scientific literature to identify western drugs with obvious side effects. Then, we find TCM alternatives for these western drugs to ameliorate their side effects. Results We used depression as a case study. To evaluate our method, we showed the relation between herb-ingredients-target-disease for representative alternative herbs of western drugs. Further, a protein-protein interaction network of western drugs and alternative herbs was produced, and we performed enrichment analysis of the targets of the active ingredients of the herbs and examined the enrichment of Gene Ontology terms for Biological Process, Cellular Component, and Molecular Function and KEGG Pathway levels, to show how these targets affect different levels of gene expression. Conclusion Our proposed method is able to select herbs that are highly relevant to the target indication (depression) and are able to treat the side effects caused by the target drug. The compounds from our selected alternative herbal medicines can therefore be complementary to the western drugs and ameliorate their side effects, which may help in the development of new drugs.

Case Study: Integrated Strategy Solves Well Test Issues in Deep-Water and Heavy-Oil Environments

2016 ◽  
Author(s):  
Cheng Zhong ◽  
Zhang Liang ◽  
Liu Zhengli ◽  
Zhang Junbin ◽  
Wang Yuezeng ◽  
...  
Keyword(s):  
Deep Water ◽  
Heavy Oil ◽  
Well Test ◽  
Integrated Strategy

scholarly journals Integrated Strategy to Curtail Illegal Gold Mining: A Case Study in Central Kalimantan, Indonesia

2021 ◽  
Vol 14 (1) ◽  
pp. 1-18
Author(s):  
Ongku Parmonangan Hasibuan ◽  
◽  
Jann Hidajat Tjakraatmadja ◽  
Yos Sunitiyoso
Keyword(s):  
Gold Mining ◽  
Model Building ◽  
Social Issues ◽  
Central Kalimantan ◽  
Illegal Mining ◽  
Integrated Strategy ◽  
Five Factors ◽  
Integrated Team ◽  
Depth Interviews

Abstract. Illegal gold mining has disturbed the operation of a mining company (Indo Muro Kencana) in Central Kalimantan since the early 1990s. Several disputes have happened, including two serious conflicts, causing financial losses, damage to facilities, and fatalities, forcing the company to stop operations in 2002 and 2013. Eventually, the original investors abandoned the site. Various countermeasures were taken, including harsh law enforcement involving police and military forces’ deployment, yet the illegal mining activities continued. Since 2015, the new management has implemented new approaches; within five years, the number of illegal miners has decreased considerably. This study aims to identify the reasons behind the disputes and how the new management reduces illegal mining within its concession without triggering further conflict. This research is a case study using in-depth interviews, complemented by a study of corporate and media documents. Five factors were identified behind the previous conflicts. The new management’s integrated strategy to manage social issues, including illegal mining, started with social mapping, then an integrated team to deal with social issues was established, and finally, an integrated plan was introduced with four agendas: engagement, presence, respect and inclusiveness, and cohesiveness. This study contributes to company-community model building in similar circumstances and, in practice, offers a solution to curtail illegal gold mining, particularly in Indonesia. Keywords: Conflict, illegal gold mining, illegal miners, integrated, Kalimantan.

scholarly journals Heavy metal constituent of medicinal plants: a case study of Moringa oleifera Lam. from selected areas in Accra, Ghana

2021 ◽  
Vol 2 (1) ◽  
pp. 181-188
Author(s):  
Michael Lartey ◽  
Samuel Frimpong-Manso ◽  
Prince Osei Banahene ◽  
Adolphina Addo-Lartey ◽  
Nathaniel N A Okine ◽  
...  
Keyword(s):  
Medicinal Plants ◽  
Moringa Oleifera ◽  
Anthropogenic Activities ◽  
Total Concentration ◽  
Natural Habitat ◽  
Herbal Medicines ◽  
Translocation Factor ◽  
Sample Collection ◽  
Moringa Oleifera Lam

Background: Anthropogenic activities release metals into the environment that could be absorbed by plants and assimilate into herbal medicines. Objective: This study sought to correlate the outcome of anthropogenic activities that release metals into the environment with levels of metals in medicinal plants using the leaves of Moringa oleifera Lam. (M. oleifera)as a case study. Methods: Leaves of M. oleifera and soil around sampled plants were collected from three locations in the Accra Metropolis: a commercial area, an area with dense vehicular traffic, and a quasi-natural habitat. Samples were analyzed with Energy Dispersive X-ray Fluorescence (ED-XRF) spectroscopy for the presence and levels of arsenic (As), cobalt (Co), chromium (Cr), copper (Cu), nickel (Ni), lead (Pb), vanadium (V) and zinc (Zn). Statistical analyses were performed and the correlation between metal concentrations in leaves and soil was assessed using Spearman’s correlation coefficient. Results: Levels of metals in the leaves and soil samples varied with the site of sample collection. Levels of metals in leaves were significantly lower than permissible limits (p< 0.05) in herbal medicines. Translocation factor (TF) estimates indicated that the M. oleifera leaves exclude the metals under investigation irrespective of the site of collection. However, the TF > 1 in the case of Zn from the quasi-natural habitat signifying bioaccumulation in the leaves. Except forCo, the total concentration of each metal in the soil was not correlated with its concentration in the leaves. Conclusion: The concentration of sampled metals in the leaves and soil varied with the site of sampling and potentially with the anthropogenic activities that release metals into that environment.

Integrating Price-Incentive and Trip-Selection Policies to Rebalance Shared Electric Vehicles

2020 ◽  
Vol 12 (4) ◽  
pp. 148-173
Author(s):  
Zihao Jiao ◽  
Lun Ran ◽  
Xin Liu ◽  
Yuli Zhang ◽  
Robin G. Qiu
Keyword(s):  
Electric Vehicle ◽  
Traffic Congestion ◽  
Travel Demand ◽  
Exact Algorithm ◽  
Labor Cost ◽  
Environmental Benefits ◽  
Mixed Integer ◽  
Fleet Size ◽  
Integrated Strategy

Because electric vehicle sharing (EVS) offers the advantages of high flexibility and convenience, it has been receiving increasing attention worldwide as an effective approach to easing traffic congestion and environmental pollution. However, unbalanced electric vehicle distribution is an obstacle in the development of EVS. In this paper, we propose an integrated strategy to mitigate the imbalance issue and enhance customers’ adoption of EVS. We construct an integrated strategy that combines the price-incentive approach with the trip-selection policy and models uncertain travel demand in a continuous trip-adopting process based on our integrated strategy. Aiming to improve EVS operating profits, we apply spatiotemporal nonlinear mixed-integer programming to formulate the travel pricing and rebalancing plan. Additionally, we approximate the model in a tractable form after analyzing the optimal service adoption and develop an efficient exact algorithm to handle the nonlinear items. The computational results of a real-world car2go Amsterdam case study demonstrate several economic and environmental benefits generated by our integrated policy, including (i) higher profits for EVS operators, (ii) improved service satisfaction for consumers, and (iii) a higher level of carbon emissions reduction, from 381 grams per mile to 225 grams per mile, beneficial for the social environment. Moreover, according to the case study, an appropriate initial fleet size, high rebalancing frequency, low labor cost, high potential travel demands, and short charging time also benefit EVS operation.

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