Detection of a negative correlation between prescription of Chinese herbal products containing coumestrol, genistein or daidzein and risk of subsequent endometrial cancer among tamoxifen-treated female breast cancer survivors in Taiwan between 1998 and 2008: A population-based study

2015 ◽  
Vol 169 ◽  
pp. 356-362 ◽  
Author(s):  
Yi-Cheng Hu ◽  
Chien-Tung Wu ◽  
Jung-Nien Lai ◽  
Yueh-Ting Tsai
2015 ◽  
Vol 2015 ◽  
pp. 1-11 ◽  
Author(s):  
Wei-Lung Hsu ◽  
Yueh-Ting Tsai ◽  
Chien-Tung Wu ◽  
Jung-Nien Lai

Background.The purpose of our study is to analyze the association between prescribed Chinese herbal products (CHPs) containingGinsengand the risk of endometrial cancer among tamoxifen (TMX) users and to identify any possible interactive effects betweenGinsengand TMX with respect to preventing the development of subsequent endometrial cancer in an estrogen-dependent breast cancer population in Taiwan.Methods.All patients newly diagnosed with invasive breast cancer receiving tamoxifen treatment from January 1, 1998, to December 31, 2008, were selected from the National Health Insurance Research Database. The usage, frequency of service, and CHP-Ginsengprescribed across the 30,556 TMX-treated breast cancer (BC) survivors were evaluated. Logistic regression was employed to estimate the odds ratios (ORs) for the utilization of CHP-Ginseng. Cox’s proportional hazard regression was performed to calculate the hazard ratios (HRs) for endometrial cancer associated withGinsenguse among the TMX-treated BC cohort.Results.The HR for the development of endometrial cancer among breast cancer survivors who had ever takenGinsengafter TXM treatment was significantly decreased compared to those who never used CHP.Conclusion.A significant inhibitory relationship betweenGinsengconsumption and subsequent endometrial cancer less than 2 years after TMX treatment was detected among BC survivors.


BMC Cancer ◽  
2014 ◽  
Vol 14 (1) ◽  
Author(s):  
Jian Zhu ◽  
Jian-Guo Chen ◽  
Yong-Sheng Chen ◽  
Yong-Hui Zhang ◽  
Lu-Lu Ding ◽  
...  

2013 ◽  
Vol 24 (9) ◽  
pp. 1705-1715 ◽  
Author(s):  
Stacey L. Tannenbaum ◽  
Tulay Koru-Sengul ◽  
Feng Miao ◽  
Margaret M. Byrne

2014 ◽  
Vol 5 (2) ◽  
pp. 151-155 ◽  
Author(s):  
Ju-Yin Chen ◽  
Shou-Jen Kuo ◽  
Yung-Po Liaw ◽  
Itzhak Avital ◽  
Alexander Stojadinovic ◽  
...  

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