Ulmus macrocarpa Hance improves benign prostatic hyperplasia by regulating prostatic cell apoptosis

2019 ◽  
Vol 233 ◽  
pp. 115-122 ◽  
Author(s):  
Jinhyung Rho ◽  
Chang-Seob Seo ◽  
Hee-Seon Park ◽  
Charith UB Wijerathne ◽  
Hye-Yun Jeong ◽  
...  
Keyword(s):  
Benign Prostatic Hyperplasia ◽  
Cell Apoptosis ◽  
Prostatic Hyperplasia ◽  
Prostatic Cell

scholarly journals Qianliening capsule treats benign prostatic hyperplasia via induction of prostatic cell apoptosis

2013 ◽  
Vol 7 (3) ◽  
pp. 848-854 ◽  
Author(s):  
HAIYIN ZHENG ◽  
WEI XU ◽  
JIUMAO LIN ◽  
JUN PENG ◽  
ZHENFENG HONG
Keyword(s):  
Benign Prostatic Hyperplasia ◽  
Cell Apoptosis ◽  
Prostatic Hyperplasia ◽  
Prostatic Cell

scholarly journals NELL2 Modulates Cell Proliferation and Apoptosis via ERK Pathway in the Development of Benign Prostatic Hyperplasia

2021 ◽  
Author(s):  
Jianmin Liu ◽  
Daoquan Liu ◽  
Xueneng Zhang ◽  
Yan Li ◽  
Xun Fu ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Benign Prostatic Hyperplasia ◽  
Cell Apoptosis ◽  
Prostatic Hyperplasia ◽  
Human Prostate ◽  
Immunofluorescent Staining ◽  
Erk Pathway ◽  
Prostate Cell ◽  
Mesenchymal Transition ◽  
Dependent Cell

Benign prostatic hyperplasia (BPH) is a quite common illness but its etiology and mechanism remain unclear. Neural epidermal growth factor-like like 2 (NELL2) plays multifunctional roles in neural cell growth and is strongly linked to the urinary tract disease. Current study aims to determine the expression, functional activities and underlying mechanism of NELL2 in BPH. Human prostate cell lines and tissues from normal human and BPH patients were utilized. Immunohistochemical staining, immunofluorescent staining, RT-PCR and Western-blotting were performed. We further generated cell models with NELL2 silenced or overexpressed. Subsequently, proliferation, cycle, and apoptosis of prostate cells were determined by CCK-8 assay and flow cytometry analysis. The epithelial-mesenchymal transition (EMT) and fibrosis process were also analyzed. Our study revealed that NELL2 was upregulated in BPH samples and localized in the stroma and the epithelium compartments of human prostate tissues. NELL2 deficiency induced a mitochondrial-dependent cell apoptosis, and inhibited cell proliferation via phosphorylating ERK1/2 activation. Additionally, suppression of ERK1/2 with U0126 incubation could significantly reverse NELL2 deficiency triggered cell apoptosis. Consistently, overexpression of NELL2 promoted cell proliferation and inhibited cell apoptosis. However, NELL2 interference was observed no effect on EMT and fibrosis process. Our novel data demonstrated that upregulation of NELL2 in the enlarged prostate could contribute to the development of BPH through enhancing cell proliferation and inhibited a mitochondrial-dependent cell apoptosis via the ERK pathway. The NELL2-ERK system might represent an important target to facilitate the development of future therapeutic approaches in BPH.

Stromal/epithelial interactions of murine prostatic cell lines in vivo: A model for benign prostatic hyperplasia and the effect of doxazosin on tissue size

The Prostate ◽  
2002 ◽  
Vol 54 (1) ◽  
pp. 17-24 ◽  
Author(s):  
Tetsuya Takao ◽  
Akira Tsujimura ◽  
Sandra Coetzee ◽  
Sarah N. Salm ◽  
Herbert Lepor ◽  
...  
Keyword(s):  
Benign Prostatic Hyperplasia ◽  
Cell Lines ◽  
Prostatic Hyperplasia ◽  
Tissue Size ◽  
Prostatic Cell

1505: Evaluation of Bother Score for Each Symptom is Necessary for Managemnt of QOL in Patients with Lower Urinary TRCT Symptoms (LUTS) Suggestive of Benign Prostatic Hyperplasia (BPH)

2007 ◽  
Vol 177 (4S) ◽  
pp. 496-497
Author(s):  
Masaki Yoshida ◽  
Akita Inadome ◽  
Koichi Masunaga ◽  
Yoshihiro Maeda ◽  
You Satoji ◽  
...  
Keyword(s):  
Benign Prostatic Hyperplasia ◽  
Prostatic Hyperplasia ◽  
Lower Urinary
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