Chemical characterization and bioactive potential of Thymus × citriodorus (Pers.) Schreb. preparations for anti-acne applications: Antimicrobial, anti-biofilm, anti-inflammatory and safety profiles

2021 ◽  
pp. 114935
Author(s):  
Ana S. Oliveira ◽  
Joana Rolo ◽  
Carlos Gaspar ◽  
Carlos Cavaleiro ◽  
Lígia Salgueiro ◽  
...  
Keyword(s):  
Chemical Characterization ◽  
Anti Inflammatory ◽  
Bioactive Potential

Bioactive potential of culturable fungal endophytes isolated from leaf of Catharanthus roseus (L.) G. Don

2021 ◽  
Vol 21 ◽  
Author(s):  
Sucheta Singh ◽  
Surjeet Verma ◽  
Dharmendra Kumar Yadav ◽  
Anant Kumar ◽  
Rekha Tyagi ◽  
...  
Keyword(s):  
Catharanthus Roseus ◽  
Crude Extract ◽  
Inhibitory Concentration ◽  
Efflux Pump ◽  
Fungal Endophytes ◽  
Bacterial Pathogen ◽  
Bioactive Compound ◽  
Major Constituent ◽  
Anti Inflammatory ◽  
Bioactive Potential

Introduction: Endophyte is considered as a source of natural bioactive secondary metabolites that provides an array of bioactive lead compounds. The present study was aimed to determine the antimicrobial and anti-inflammatory potential of fungal endophytes isolated from Catharanthus roseus. Methods: A total of seven fungal endophytes crude extract were screened against bacterial pathogens. Of these, Curvularia geniculata CATDLF7 crude extract exhibited the most potent inhibitory activity against bacterial pathogen. Hence, CATDLF7 crude extract was subjected to the chromatographic separation. This purification leads to the isolation of six pure compounds (1PS - 6PS). Of these, 3PS was found to be a major constituent and most effective against clinical isolates of methicillin resistant Staphylococcus aureus (MRSA) with minimum inhibitory concentration (MIC) values ranging from 100 to 200 μg/ml. Based on the spectroscopic data, 3PS was characterized as α,β-dehydrocurvularin. This compound also showed synergistic interaction with norfloxacin, and reduced its MIC up to 32-folds with fractional inhibitory concentration index (FICI) of 0.09. Results: To understand the possible antibacterial mechanism of action, α,β-dehydrocurvularin alone (100 μg/ml) exhibited efflux pump inhibitory potential by 0.84 fold decreasing in ethidium bromide (EtBr) fluorescence. In addition, α,β-dehydrocurvularin inhibited inflammatory cytokines TNF-α and IL-6 production which is further validated by molecular docking score -4.921 and -5.641 respectively for understanding orientation and binding affinity. Conclusion: Overall the results highlighted to identifying bioactive compound α,β-dehydrocurvularin which could be used as an antimicrobial and anti-inflammatory agents.

Chemical Characterization and Anti-inflammatory Activity of Polysaccharides from Zizyphus jujube cv. Muzao

2017 ◽  
Vol 13 (7) ◽  
Author(s):  
Xiaolong Ji ◽  
Qiang Peng ◽  
Huanyu Li ◽  
Fang Liu ◽  
Min Wang
Keyword(s):  
Chemical Characterization ◽  
Type I ◽  
Dependent Manner ◽  
Necrosis Factor Alpha ◽  
Assisted Extraction ◽  
Ultrasonic Assisted ◽  
Potential Applications ◽  
Anti Inflammatory ◽  
Zizyphus Jujube

AbstractPolysaccharides fromZizyphus jujube cv. Muzao(ZMP) were extracted by ultrasonic-assisted extraction with acidic buffer. The chemical composition and antioxidant and anti-inflammatory activities of ZMP were evaluated. The results revealed that ZMP had a molecular weight of 89.90 kDa and consisted of arabinose, galactose, glucose, rhamnose, and mannose, with molar percentages of 4.52 %, 2.64 %, 1.04 %, 0.49 %, and 0.41 %, respectively. Based on Fourier-transform infrared spectroscopy, ZMP belonged to the type I rhamnogalacturonans family. In vitro antioxidants assays revealed that ZMP had remarkable antioxidant activity in a dose-dependent manner. Proinflammatory cytokines, such as interleukin-6 and tumor necrosis factor alpha, were suppressed by ZMP in lipopolysaccharide-treated RAW264.7 cells. Overall, the results revealed that ZMP has potential applications as a natural anti-inflammatory agent.

Essential oil and its nanoemulsion of Araucaria heterophylla resin: Chemical characterization, anti-inflammatory, and antipyretic activities

2020 ◽  
Vol 148 ◽  
pp. 112272 ◽  
Author(s):  
Abdelsamed I. Elshamy ◽  
Naglaa M. Ammar ◽  
Heba A. Hassan ◽  
Saud L. Al-Rowaily ◽  
Tamer I. Ragab ◽  
...  
Keyword(s):  
Essential Oil ◽  
Chemical Characterization ◽  
Araucaria Heterophylla ◽  
Anti Inflammatory

Chemical characterization and anti-inflammatory activity of luteolin glycosides isolated from lemongrass

2014 ◽  
Vol 10 ◽  
pp. 436-443 ◽  
Author(s):  
Vera Francisco ◽  
Artur Figueirinha ◽  
Gustavo Costa ◽  
Joana Liberal ◽  
Maria Celeste Lopes ◽  
...  
Keyword(s):  
Chemical Characterization ◽  
Inflammatory Activity ◽  
Anti Inflammatory

Sphenodesme involucrata var. paniculata (C.B. Clarke) Munir.: Chemical characterization, anti-nociceptive and anti-inflammatory activities of methanol extract of leaves

2018 ◽  
Vol 225 ◽  
pp. 71-80 ◽  
Author(s):  
Puthanpura Sasidharan Sreeja ◽  
Karuppusamy Arunachalam ◽  
Domingos Tabajara de Oliveira Martins ◽  
Joaquim Corsino da Silva Lima ◽  
Sikiru Olaitan Balogun ◽  
...  
Keyword(s):  
Methanol Extract ◽  
Chemical Characterization ◽  
Anti Inflammatory

scholarly journals Morus alba L. and Morus nigra L. Leaves as a Promising Food Source of Phenolic Compounds with Antioxidant Activity

2021 ◽  
Author(s):  
Milena Polumackanycz ◽  
Marek Wesolowski ◽  
Agnieszka Viapiana
Keyword(s):  
Antioxidant Activity ◽  
Phenolic Compounds ◽  
Chemical Characterization ◽  
Morus Alba ◽  
Mulberry Leaves ◽  
Morus Nigra ◽  
Antioxidant Agents ◽  
White Mulberry ◽  
Bioactive Potential ◽  
Promising Source

AbstractBioactivity of mulberry has been widely described, but mostly related to its fruits, while studies with leaves are scarce. Herein, in this study leaves of two mulberry species (Morus alba L. and Morus nigra L.) were characterized, compared, and evaluated in terms of their phenolic composition and antioxidant activity. Aiming to valorize mulberry leaves extracts which can be included in modern diet four different extracts (infusions, decoctions, tinctures and hydromethanolic) were examined. The chemical characterization was done by quantifying total phenolics (TPC), flavonoids (TFC) and phenolic acids (TPAC) content, L( +)ascorbic acid (ASA) and individual phenolic compounds in the extracts by HPLC technique. Moreover, DPPH and FRAP assays were used to assess the antioxidant activity of white and black mulberry leaves. Findings of these studies revealed that black mulberry leaves were richer in TFC and TPAC, while white mulberry leaves contained higher levels of individual phenolic compounds in water extracts. Gallic acid was found in the highest concentrations in two mulberry leave extracts. Correlation analysis showed strong relationships between antioxidant activity and TPC and TFC. This fact suggests the crucial role of phenolic compounds as antioxidant agents in white and black mulberry leaves. The results obtained in this study demonstrate that leaves of both white and black mulberry can be used as a valuable source of phenolic compounds with bioactive potential, which can be applied in the food sector, as foods and as promising source of natural ingredients.

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