Involvement of nitric oxide and prostacyclin in the antihypertensive effect of low-molecular-weight procyanidin rich grape seed extract in male spontaneously hypertensive rats

2014 ◽  
Vol 6 ◽  
pp. 419-427 ◽  
Author(s):  
M. Quiñones ◽  
L. Guerrero ◽  
S. Fernández-Vallinas ◽  
Z. Pons ◽  
L. Arola ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Molecular Weight ◽  
Spontaneously Hypertensive Rats ◽  
Antihypertensive Effect ◽  
Grape Seed Extract ◽  
Grape Seed ◽  
Seed Extract ◽  
Low Molecular Weight ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive

Anti-hypertensive effect of grape seed extract in male spontaneously hypertensive rats

2015 ◽  
Vol 24 (6) ◽  
pp. 2229-2233 ◽  
Author(s):  
Hyun-Ho Jang ◽  
Seung Kook Park ◽  
Ga-Young Choi ◽  
Ji-Ho Park ◽  
Tae-Hoon Lee ◽  
...  
Keyword(s):  
Spontaneously Hypertensive Rats ◽  
Grape Seed Extract ◽  
Grape Seed ◽  
Seed Extract ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive

scholarly journals Antihypertensive Effects of Virgin Olive Oil (Unfiltered) Low Molecular Weight Peptides with ACE Inhibitory Activity in Spontaneously Hypertensive Rats

Nutrients ◽  
2020 ◽  
Vol 12 (1) ◽  
pp. 271 ◽  
Author(s):  
Juan María Alcaide-Hidalgo ◽  
Miguel Romero ◽  
Juan Duarte ◽  
Eduardo López-Huertas
Keyword(s):  
Molecular Weight ◽  
Inhibitory Activity ◽  
Spontaneously Hypertensive Rats ◽  
Virgin Olive Oil ◽  
Antihypertensive Activity ◽  
Low Molecular Weight ◽  
Hypertensive Rats ◽  
Ace Inhibitory Activity ◽  
Spontaneously Hypertensive ◽  
Ace Inhibitory

The low molecular weight peptide composition of virgin olive oil (VOO) is mostly unknown. We hypothesised that unfiltered VOO could possess low molecular weight peptides with antihypertensive activity. We produced unfiltered VOO and obtained a water-soluble peptide extract from it. The peptides were separated by size-exclusion using fast protein liquid chromatography, and the low molecular weight fraction was analysed by nanoscale liquid chromatography-Orbitrap coupled with tandem mass spectrometry and de novo sequencing. We selected 23 peptide sequences containing between 6 and 9 amino acids and molecular masses ranging 698–1017 Da. Those peptides were chemically synthesised and their angiotensin-converting enzyme (ACE) inhibitory activity was studied in vitro. Seven peptides showed a strong activity, with half maximal inhibitory concentration (IC50) <10 µm. The antihypertensive effects of the four most active synthesised ACE inhibitor peptides were studied in spontaneously hypertensive rats (SHR). Acute oral administration of synthetic peptides RDGGYCC and CCGNAVPQ showed antihypertensive activity in SHR. We conclude that unfiltered VOO naturally contains low molecular weight peptides with specific ACE inhibitory activity and antihypertensive effects in SHR.

Antihypertensive Effect of Propranolol in Conscious Spontaneously Hypertensive Rats

1982 ◽  
Vol 4 (6) ◽  
pp. 903-914 ◽  
Author(s):  
J. F. M. Smits ◽  
T. G. Coleman ◽  
T. L. Smith ◽  
C. M. Kasbergen ◽  
H. van Essen ◽  
...  
Keyword(s):  
Spontaneously Hypertensive Rats ◽  
Antihypertensive Effect ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive

Two different approaches to restore renal nitric oxide and prevent hypertension in young spontaneously hypertensive rats: l-citrulline and nitrate

2014 ◽  
Vol 163 (1) ◽  
pp. 43-52 ◽  
Author(s):  
Shao-Ju Chien ◽  
Kuan-Miao Lin ◽  
Hsuan-Chang Kuo ◽  
Chien-Fu Huang ◽  
Ying-Jui Lin ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Spontaneously Hypertensive Rats ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive

scholarly journals The antihypertensive effect of orally administered nifedipine-loaded nanoparticles in spontaneously hypertensive rats

1997 ◽  
Vol 120 (3) ◽  
pp. 399-404 ◽  
Author(s):  
Young Il Kim ◽  
Laurence Fluckiger ◽  
Maurice Hoffman ◽  
Isabelle Lartaud-Idjouadiene ◽  
Jeffrey Atkinson ◽  
...  
Keyword(s):  
Spontaneously Hypertensive Rats ◽  
Antihypertensive Effect ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive
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