scholarly journals Immunotherapy and targeted therapies in older patients with advanced melanoma; Young International Society of Geriatric Oncology review paper

2019 ◽  
Vol 10 (3) ◽  
pp. 389-397 ◽  
Author(s):  
Esther Bastiaannet ◽  
Nicolò Battisti ◽  
Kah Poh Loh ◽  
Nienke de Glas ◽  
Enrique Soto-Perez-de-Celis ◽  
...  
2020 ◽  
Vol 11 (1) ◽  
pp. 1-7 ◽  
Author(s):  
Schroder Sattar ◽  
Cindy Kenis ◽  
Kristen Haase ◽  
Peggy Burhenn ◽  
Petra Stolz-Baskett ◽  
...  

2020 ◽  
Vol 22 (10) ◽  
Author(s):  
Nicolò Matteo Luca Battisti ◽  
Gabor Liposits ◽  
Nienke Aafke De Glas ◽  
Fabio Gomes ◽  
Capucine Baldini ◽  
...  

2019 ◽  
Vol 10 (2) ◽  
pp. 337-345 ◽  
Author(s):  
Gabor Liposits ◽  
Kah Poh Loh ◽  
Enrique Soto-Perez-de-Celis ◽  
Lucy Dumas ◽  
Nicolò Matteo Luca Battisti ◽  
...  

2020 ◽  
Vol 11 (2) ◽  
pp. 217-224 ◽  
Author(s):  
Sindhuja Kadambi ◽  
Enrique Soto-Perez-de-Celis ◽  
Tullika Garg ◽  
Kah Poh Loh ◽  
Jessica L. Krok-Schoen ◽  
...  

2020 ◽  
Vol 11 (2) ◽  
pp. 203-211 ◽  
Author(s):  
Clark DuMontier ◽  
Mina S. Sedrak ◽  
Wee Kheng Soo ◽  
Cindy Kenis ◽  
Grant R. Williams ◽  
...  

2018 ◽  
Vol 10 ◽  
pp. 175883591880961 ◽  
Author(s):  
Nicolò Matteo Luca Battisti ◽  
Nienke De Glas ◽  
Mina S. Sedrak ◽  
Kah Poh Loh ◽  
Gabor Liposits ◽  
...  

The current standard of care for the management of estrogen receptor (ER)-positive and human epidermal growth factor receptor 2 (HER2)-negative breast cancer has been redefined by the introduction of cyclin-dependent kinase 4/6 (CDK4/6) inhibitors. Although adults aged 65 years and older account for the majority of patients with breast cancer, limited data are available about the age-specific dosing, tolerability, and benefit of CDK4/6 inhibitors in this growing population. Older adults are under-represented in clinical trials and as a result, clinicians are forced to extrapolate from findings in younger and healthier patients when making treatment decisions for older patients. In this article, we review the limited age-specific evidence on the efficacy, toxicity, and quality of life (QoL) outcomes associated with the use of CDK4/6 inhibitors in older adults. We also describe ongoing trials evaluating CDK4/6 inhibitors in the older population and highlight that only a minority of adjuvant and metastatic trials of CDK4/6 inhibitors in the general breast cancer population includes geriatric assessments. Finally, we propose potential strategies to help guide decision making for fit and unfit older patients based on disease endocrine sensitivity, the need for rapid response and geriatric assessment.


2015 ◽  
Vol 26 (3) ◽  
pp. 463-476 ◽  
Author(s):  
D. Papamichael ◽  
R.A. Audisio ◽  
B. Glimelius ◽  
A. de Gramont ◽  
R. Glynne-Jones ◽  
...  

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