scholarly journals 432 Patient and device generated variability in platelet-derived growth factors during platelet-rich plasma therapy for hair loss

2019 ◽  
Vol 139 (5) ◽  
pp. S74
Author(s):  
M. Hordinsky ◽  
N. Estharabadi ◽  
R. Farah ◽  
J. Mohammed
Keyword(s):  
Growth Factors ◽  
Hair Loss ◽  
Platelet Rich Plasma ◽  
Plasma Therapy

Using platelet-rich plasma to treat hair loss and thinning

2020 ◽  
Vol 9 (8) ◽  
pp. 326-332
Author(s):  
Daniel Sister
Keyword(s):  
Stem Cells ◽  
Growth Factors ◽  
Hair Loss ◽  
Real Option ◽  
Platelet Rich Plasma ◽  
Men And Women ◽  
Technological Advances ◽  
Long Time ◽  
Chemical Products ◽  
Folk Remedies

Hair loss and thinning have always been a huge concern for men and women across the globe. Numerous treatments have been tried and tested, ranging rom folk remedies to chemical products. Unfortunately, none have proven a regular efficacy, without mentioning the possible side effects. So, for a long time, the only real option was hair graft. Now, with technological advances in both growth factors and stem cells, we have a possible solution that is efficient, safe and reproductible: platelet-rich plasma.

scholarly journals Intraovarian insertion of autologous platelet growth factors as cell-free concentrate: Fertility recovery and first unassisted conception with term delivery at age over 40

2020 ◽  
Author(s):  
E. Scott Sills ◽  
Natalie S. Rickers ◽  
Samuel H. Wood
Keyword(s):  
Growth Factors ◽  
In Vitro Fertilization ◽  
Platelet Rich Plasma ◽  
Male Infant ◽  
Injection Technique ◽  
Plasma Therapy ◽  
Vitro Fertilization ◽  
Plasma Cytokines ◽  
Autologous Platelet

Background: The use of autologous platelet-rich plasma as an ovarian treatment has not been standardized and remains controversial. Case Presentation: A 41½-year old woman with diminished ovarian reserve (serum anti- Müllerian hormone = 0.163 mg/mL) and a history of 10 unsuccessful in vitro fertilization cycles presented for reproductive endocrinology consult. She and her partner declined donor oocyte in vitro fertilization. They were both in good general health and laboratory tests were unremarkable, except for mild thrombocytosis (platelets = 386K; normal range 150-379K) discovered in the female. The patient underwent intraovarian injection of fresh platelet-derived growth factor concentrate administered as an enriched cell-free substrate. Serum anti- Müllerian hormone increased by 115% within 6 wks of treatment. Spontaneous ovulation occurred the month after injection and subsequently the serum human chorionic gonadotropin was noted at 804 mIU/mL. Following an uneventful obstetrical course, a male infant was delivered at term without complication. Conclusion: This is the first description of intraovarian injection of enriched platelet-derived growth factors followed by unassisted pregnancy and live birth. As a refinement of conventional ovarian platelet-rich plasma therapy, this procedure may be particularly valuable for refractory cases where prognosis for pregnancy appears especially bleak. A putative role for thrombocytosis is also viewed in parallel with mechanisms of action as advanced earlier. With continued experience in ovarian application of autologous platelet growth factors, additional research will evaluate laboratory protocol/sample preparation, injection technique, and patient selection. Key words: Ovarian rejuvenation, Platelet-rich plasma, Cytokines, Infertility, IVF.

scholarly journals A Study of the Efficacy of Skin Needling and Platelet Rich Plasma in the Treatment of Acne Scars

2017 ◽  
Vol 15 (1) ◽  
pp. 17-23
Author(s):  
Shivani Ranjan ◽  
RS Gupta ◽  
S Gupta
Keyword(s):  
Wound Healing ◽  
Growth Factors ◽  
Platelet Rich Plasma ◽  
Monthly Interval ◽  
P Value ◽  
Collagen Deposition ◽  
Acne Scar ◽  
Plasma Therapy ◽  
Acne Scars ◽  
Combined Use

Introduction: Permanent scars are the major complications of acne. Correction of scars is the priority for acne patients. Platelet-rich plasma (PRP) may be useful in the treatment of atrophic acne scars by promoting collagen deposition. Skin needling also releases growth factors, initiate a cascade of wound healing resulting in collagen production. Hence, skin needling and PRP should act synergistically to improve acne scars.Objective: To assess the effectiveness of the combined use of skin needling and PRP application in acne scar treatment.Material and Methods: The study enrolled 10 patients of acne scars. Platelet rich plasma therapy with needling was given to them at monthly interval for a therapeutic period of 6 months. The effects of therapy were evaluated based on photographic assessment and patient’s satisfaction.Results: Mean age of the patients was 28.10 ± 5.065. Twenty percent of patients showed excellent response, 80% showed good response. The results were found to be significant with p value < 0.014. Pain and edema were major complaints which subsided in 1-2 days.Conclusion: Platelet rich plasma therapy combined with skin needling is a safe and effective treatment for management of acne scars.

The “biological chamber” method – use of autologous platelet-rich plasma (PRP) in the treatment of poorly healing lower-leg ulcers of venous origin

2015 ◽  
Vol 87 (6) ◽  
Author(s):  
Dariusz Waniczek ◽  
Wojciech Mikusek ◽  
Tomasz Kamiński ◽  
Mariusz Wesecki ◽  
Zbigniew Lorenc ◽  
...  
Keyword(s):  
Growth Factors ◽  
Chronic Wounds ◽  
Platelet Rich Plasma ◽  
Healing Process ◽  
Lower Leg ◽  
Complete Healing ◽  
Leg Ulcers ◽  
Plasma Therapy ◽  
Autologous Platelet Rich Plasma ◽  
Autologous Platelet

AbstractWound healing is a complex pathophysiological process, in which platelets play a crucial role. Platelet alpha-granules release growth factors to the wound bed; the factors are necessary in the healing process. In chronic wounds, such as poorly healing lower-leg ulcers of venous origin, there is decreased activity of multiple growth factors, so the concept of exogenous delivery of such factors seems a logical strategy. Platelet-rich plasma therapy in patients with lower-leg ulcers of venous origin combined with conventional treatment methods (previously ineffective in these patients) seems, based on our observation, an important adjunct leading to recovery.The aim of the study was to present an original method of autologous platelet-rich plasma application through the creation of a sort of “biological chamber” containing a concentrate of growth factors.Material and methods. The described therapy was implemented in 10 patients, who had been ineffectively treated for more than one year in the outpatient setting. Patients with exacerbation of inflammatory process, signs of wound infection and ankle brachial pressure index < 0.8 were excluded from the study. After the application of platelet-rich plasma, further treatment was continued with the use of moist therapy and compression therapy according to a uniform regimen.Results. Complete healing was achieved within 4-10 weeks from the beginning of the product administration in all patients.Conclusion. The presented method seems technically simple, effective and relatively inexpensive

Using platelet-rich plasma to treat hair loss and thinning

2020 ◽  
Vol 9 (10) ◽  
pp. 420-426
Author(s):  
Daniel Sister
Keyword(s):  
Stem Cells ◽  
Growth Factors ◽  
Hair Loss ◽  
Real Option ◽  
Platelet Rich Plasma ◽  
Men And Women ◽  
Technological Advances ◽  
Long Time ◽  
Chemical Products ◽  
Folk Remedies

Hair loss and thinning have always been a huge concern for men and women across the globe. Numerous treatments have been tried and tested, ranging rom folk remedies to chemical products. Unfortunately, none have proven a regular efficacy, without mentioning the possible side effects. So, for a long time, the only real option was hair graft. Now, with technological advances in both growth factors and stem cells, we have a possible solution that is efficient, safe and reproducible: platelet-rich plasma.

scholarly journals Advantages and Clinical Applications of Lyophilized Platelet-Rich Plasma in Various Disease Conditions: A Review

2021 ◽  
Vol 9 (11) ◽  
pp. 1885-1892
Author(s):  
Pradeep Mahajan
Keyword(s):  
Growth Factors ◽  
Platelet Rich Plasma ◽  
Autologous Blood ◽  
Healing Process ◽  
Coagulation Factor ◽  
The Body ◽  
Plasma Therapy ◽  
Plasma Fraction ◽  
Wide Range ◽  
Platelet Concentration

Abstract: Platelet rich plasma (PRP) is a biological product defined as a portion of the plasma fraction of autologous blood with a platelet concentration above the baseline. The plasma occupies 55% of blood, which is rich in immunoglobulins and proteins that have a wide range of applications in various medical fields. Plasma therapy is applied to tackle various disorders or diseases as it induces the body to develop new healthy cells. It contains important components like antibodies, coagulation factor, enzymes, fibrinogen, proteins and albumin. PRP is a unique and advanced treatment which helps to increases the body’s natural healing process. Platelet lysate which is obtained from platelet rich plasma consist of various growth factors such as chemokines, cytokines, and antibacterial molecules and also has anti-inflammatory, immunomodulatory, anti-fibrotic and repairing effects. As PRP is rich in the proteins and several antibodies, it is used for various chronic therapies such as hemophilia and autoimmune disorders as well as in various severe health problems. Lyophilized Platelet-rich plasma (LPRP) therapy is currently used in various fields such as in tissue regeneration, wound healing, scar revision, skin rejuvenating effects, alopecia and for the coronavirus disease (COVID-19). It is also used to heal wounds and illnesses. LPRP therapy is gaining attraction by many health professionals as it is a safe, effective, efficient, and easy approach in procuring, preserving, and therapy. In this review we described the advantages and applications of using lyophilized PRP in various diseases which might found to be effective in different treatment. Keywords: Plasma, Platelet, Growth Factors, Lyophilized platelet rich plasma.

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