scholarly journals A Study of the Efficacy of Skin Needling and Platelet Rich Plasma in the Treatment of Acne Scars

2017 ◽  
Vol 15 (1) ◽  
pp. 17-23
Author(s):  
Shivani Ranjan ◽  
RS Gupta ◽  
S Gupta
Keyword(s):  
Wound Healing ◽  
Growth Factors ◽  
Platelet Rich Plasma ◽  
Monthly Interval ◽  
P Value ◽  
Collagen Deposition ◽  
Acne Scar ◽  
Plasma Therapy ◽  
Acne Scars ◽  
Combined Use

Introduction: Permanent scars are the major complications of acne. Correction of scars is the priority for acne patients. Platelet-rich plasma (PRP) may be useful in the treatment of atrophic acne scars by promoting collagen deposition. Skin needling also releases growth factors, initiate a cascade of wound healing resulting in collagen production. Hence, skin needling and PRP should act synergistically to improve acne scars.Objective: To assess the effectiveness of the combined use of skin needling and PRP application in acne scar treatment.Material and Methods: The study enrolled 10 patients of acne scars. Platelet rich plasma therapy with needling was given to them at monthly interval for a therapeutic period of 6 months. The effects of therapy were evaluated based on photographic assessment and patient’s satisfaction.Results: Mean age of the patients was 28.10 ± 5.065. Twenty percent of patients showed excellent response, 80% showed good response. The results were found to be significant with p value < 0.014. Pain and edema were major complaints which subsided in 1-2 days.Conclusion: Platelet rich plasma therapy combined with skin needling is a safe and effective treatment for management of acne scars.

scholarly journals Platelet-Rich Plasma with Endothelial Progenitor Cells Accelerates Diabetic Wound Healing in Rats by Upregulating the Notch1 Signaling Pathway

2019 ◽  
Vol 2019 ◽  
pp. 1-12 ◽  
Author(s):  
Cheng Zhang ◽  
Yu Zhu ◽  
Shengdi Lu ◽  
Wanrun Zhong ◽  
Yanmao Wang ◽  
...  
Keyword(s):  
Wound Healing ◽  
Growth Factors ◽  
Signaling Pathway ◽  
Platelet Rich Plasma ◽  
Diabetic Wound ◽  
Endothelial Progenitor ◽  
Notch1 Signaling ◽  
Diabetic Wound Healing ◽  
Notch1 Signaling Pathway ◽  
Diabetic Wounds

Diabetic wounds, as a kind of refractory wound, are very difficult to heal. Both endothelial progenitor cell (EPC) transplantation and platelet-rich plasma (PRP) can improve diabetic wound healing to some extent. However, PRP application cannot provide reparative cells, while EPC transplantation cannot replenish the required growth factors for wound healing. Thus, when applied alone, neither of these factors is sufficient for effective wound healing. Furthermore, the proliferation, differentiation, and fate of the transplanted EPCs are not well known. Therefore, in this study, we examined the efficacy of combined PRP application with EPC transplantation in diabetic wound healing. Our results indicated that PRP application improved EPC proliferation and migration. The Notch signaling pathway plays a key role in the regulation of the proliferation and differentiation of stem cells and angiogenesis in wound healing. The application of PRP upregulated the Notch pathway-related gene and protein expression in EPCs. Furthermore, experiments with shNotch1-transfected EPCs indicated that PRP enhanced the function of EPCs by upregulating the Notch1 signaling pathway. In vivo studies further indicated that the combination of PRP and EPC transplantation increased neovascularization, reduced wound size, and improved healing in rat wound models. Thus, PRP application can provide the necessary growth factors for wound healing, while EPC transplantation offers the required cells, indicating that the combination of both is a potent novel approach for treating diabetic wounds.

scholarly journals The Combination of Platelet Rich Plasma with Skin Needling or Subcision for Postacne Scaring: a Serial Case Study

2020 ◽  
Vol 3 (2) ◽  
Author(s):  
Endra Yustin
Keyword(s):  
Simple Technique ◽  
Platelet Rich Plasma ◽  
Facial Skin ◽  
Combination Therapies ◽  
Acne Scar ◽  
Acne Scars ◽  
Small Needle ◽  
Male Patients ◽  
Methods Of Treatment

Scaring in acne remains a common problem and became therapeutic challenges for the clinician. Several modalities were introduced, and combination therapies are required to achieve satisfactory results. Skin needling and subcision reported as effective methods for treating acne scar. The skin needling technique involves puncturing the skin multiple times with a small needle to induce collagen growth, while subcision worked by tunneling the connective tissue and scattered the fibrosis scar. Platelet-rich plasma (PRP) influences wound-healing by stimulating an intense inflammatory response and growth factors, these increase in the production of extracellular matrix and granulation tissue occurs, with vascular in-growth, fibroblastic proliferation, and collagen production also accelerated. Three male patients enrolled in the study, with grades 2-3 acne scar. There are three different methods of treatment were used to see the effect of the treatment. The first patient used the combination of topical PRP and skin needling, and the second patient received a combination of PRP injection and subcision, while the third patient obtains combination between topical PRP and skin needling continued with PRP injection and subcision. Our study revealed that PRP and skin needling or subcision is a simple technique and has the potential for improvement of acne scars. Three weeks after treatment, all three patient had smoother facial skin and reduction of acne scar severity. The combination of PRP and skin needling or and subcision is a simple, safe and rapid method for acne scars treatment.

STUDY TO EVALUATE THE EFFICACY OF PLATELET-RICH PLASMA INJECTION IN THE MANAGEMENT OF CHRONIC NONHEALING WOUNDS

2021 ◽  
pp. 191-193
Author(s):  
Koteshwar Rao Mattigunta ◽  
S. Muqthiyar Ahamed
Keyword(s):  
Growth Factors ◽  
Platelet Rich Plasma ◽  
Cost Effective ◽  
Complete Healing ◽  
Area Measurement ◽  
P Value ◽  
Wound Area ◽  
Area Reduction ◽  
Plasma Injection ◽  
A Prospective Study

Objective: The aim was to evaluate the efcacy of platelet-rich plasma (PRP) in treating chronic non healing wounds. Non healing ulcers are a signicant health problem with a high costs in Background: terms of human and material resources. The application of autologous PRP has been a signicant breakthrough for treating non healing ulcers ,as it is an easy and cost-effective method and provides the necessary growth factors that enhance wound healing. A prospective study was conducted from September 2018 to March 2020 at Narayana Medi Methodology: cal college. A total of 30 cases with chronic non healing ulcers of various causes (traumatic, diabetic, pressure, venous ulcers),at least six weeks old with wound area measurement between 2 cm2and 10 cm2are injected with autologous platelet-rich plasma injection twice weekly. Wound contraction was measured every 4th day and represented as a percentage of healing wound area and followed up for 6 weeks. The mean age± SD of the patients was 49.36±14.05.According to Results: the etiology, non healing ulcers are again classied as traumatic, diabetic, decubitus ulcers, venous and others (postoperative wounds, Hansen's disease)which constitutes 40%,27%,17%,3%,13% respectively. The healing rates of the various ulcers were monitored in weekly intervals till the sixth week. Among 30 patients,17 patients(57%) showed complete healing ,3 patients (10%) showed 99-90% healing ,5 patients (17%) showed 80-89% healing ,5 patients(17%) showed 80-89% healing ,4 patients (13%) showed 50-79% healing,1 patients (3%) showed <50% healing. Area reduction was statistically signicant (p-value is <0.001) Conclusion: Conventional therapies do not provide good healing for chronic nonhealing ulcers as they are not able to provide the necessary growth factors essential for the healing process.PRP is a safe, affordable, biocompatible, and simple OPD based procedure for treating nonhealing ulcers.

scholarly journals EFFICACY OF FRACTIONAL CO2 LASER WITH TOPICAL PLATELET RICH PLASMA IN TREATMENT OF ACNE SCARS

2020 ◽  
Vol 4 (11) ◽  
Author(s):  
Kiran Puram ◽  
Rachana Laul ◽  
Anand Asia
Keyword(s):  
Co2 Laser ◽  
Platelet Rich Plasma ◽  
Acne Vulgaris ◽  
Tertiary Care ◽  
Acne Scar ◽  
Tertiary Care Centre ◽  
Self Assessment ◽  
Fractional Co2 Laser ◽  
Acne Scars ◽  
Quantitative Score

Background: Acne scars are most distressing sequelae of acne vulgaris having a major impact on psychosocial aspect and quality of life of an individual. In spite of various therapeutic modalities available treatment of acne scars is challenging. Resurfacing techniques such as Fractional Co2 Laser is a well-established treatment option for acne scar. Platelet-Rich Plasma (PRP), an autologous preparation of growth factors helps in wound healing and tissue regeneration. Aim: To study the efficacy of Fractional CO2 Laser with Topical Platelet-Rich Plasma in Acne scars. Materials and Methods: A total of 15 patients with atrophic facial acne scar, aged 18-40 years attending Outpatient Department of Dermatology, Venereology and Leprosy at tertiary care centre during January 2019 to December 2019 were included for this interventional study after written informed consent. The patients underwent six sessions of Fractional CO2 Laser with Topical application of Platelet-Rich Plasma at monthly intervals. Pre and post treatment comparative Goodman and Baron’s quantitative global scarring grading and patients self-assessment score were used for assessment. Results: At the end of study mild reduction in Goodman and Baron’s quantitative score for acne scar was noted in 13 patients (86.6%). Mean Goodman and Baron’s quantitative score att 4 weeks after sixth sitting was 13.13 ± 4.60. On patients self-assessment moderate resolution of acne scar was noted in 8 patients (53.3%). Conclusion: Fractional CO2 Laser with Topical Platelet-Rich Plasma application has mild to moderate improvement of acne scars and shorter down time of Fractional CO2 Laser. Keywords: Acne scar, Fractional Co2 Laser, Topical Platelet-Rich Plasma

scholarly journals EXPERIENCE OF PREMATURE EJACULATION CORRECTION BY COMBINED THERAPY OF PLATELET-RICH PLASMA AND LOW-INTENSITY SHOCK-WAVE THERAPY

2019 ◽  
pp. 33-38
Author(s):  
Юрий Заседа
Keyword(s):  
Growth Factors ◽  
Platelet Rich Plasma ◽  
Combined Therapy ◽  
Health Clinic ◽  
Penile Induration ◽  
Combined Use ◽  
Reduction Of Pain ◽  
Icd 10 ◽  
Therapeutic Model

Relevance. The spectrum of combined mechanisms of action of PRP-therapy, LISWT and LNP therapy suggests the clinical eff ect for patients with fi broplastic penile induration, which currently does not have conservative therapies that have suffi cient effi cacy.The aim of the study was to determine the effi cacy of combined PRP-therapy with intracavernous activation of growth factors by LISWT method + LNP and ICA pharmacotherapy in treatment of fi broplastic penile induction.Design. The study group comprised 23 patients of the Men’s Health Clinic in Kyiv, suff ering from fi broplastic penile inducing (Peyronie’s disease, ICD-10: N48.6) with erectile dysfunction.Results of the study. A 6-month follow-up observation showed a reduction of pain during erection, a signifi cant improvement in erectile function, a total regression of the areas less than 25 mm2 and a signifi cant decrease in the density and area of the induration areas that over 25 mm2.Conclusions. It has been established that the therapeutic model of the combined use of PRP-therapy with intracavernous activation of growth factors by LISWT method + LOD + ICA in the treatment of fi broplastic penile induration, shows a pronounced clinical eff ect, which makes this therapeutic model a promising option for conservative correction of pain and erectile dysfunction in fi broplastic penile induration.

scholarly journals Comparing the role of subcision suction method with and without the injection of platelet-rich plasma in the treatment of depressed scars

2017 ◽  
Vol 2 (2) ◽  
Author(s):  
Nouran Abd El-Aziz Abou Khedr ◽  
Tarek Mahmoud Hussein ◽  
Ayat Mohamed El-Sayed Abd El-Fatah
Keyword(s):  
Wound Healing ◽  
Platelet Rich Plasma ◽  
Slight Improvement ◽  
Moderate Improvement ◽  
Acne Scars ◽  
Significant Difference ◽  
Group A ◽  
Group B ◽  
Short Time

<p class="BodyText1">Among wound-healing modalities, platelet-rich plasma (PRP) has been used for wound healing, through the release of multiple growth factors. The platelets mediate wound healing by initiating the clotting pathway and the subsequent matrix remodelisation. The aim of the work was to study the role of injection of platelet-rich plasma in the treatment of scars. This study was conducted on thirty patients who were divided into two groups (A and B). Each group included fifteen patients. The two groups were randomly distributed by using individual sealed envelopes. Group A was subjected to subcision of their acne scars using Nokor needle, followed by suction. Group B patients were subjected to the same treatment but followed by an injection of platelet-rich plasma once per month over three months. In Group A, 6 patients (40%) showed moderate improvement, 5 patients (33.3%) showed slight improvement and 4 patients (26.7%) showed significant improvement. In Group B, 7 patients (46.7%) showed moderate improvement, 5 patients (33.3%) showed marked improvement and 3 patients (20%) showed significant improvement. There was a statistically significant difference on the independent observer’s after-treatment assessment between the groups (P=0.014). In conclusion, subcision suction leads to a persistent improvement of acne scars in a short time, and the coupling with injection of PRP is the most effective in the treatment of depressed facial scars.</p>

scholarly journals Enhanced Platelet-Rich Plasma (ePRP) Stimulates Wound Healing through Effects on Metabolic Reprogramming in Fibroblasts

2021 ◽  
Vol 22 (23) ◽  
pp. 12623
Author(s):  
Hsin-Pei Weng ◽  
Yuan-Yang Cheng ◽  
Hsin-Lun Lee ◽  
Tai-Yi Hsu ◽  
Yu-Tang Chang ◽  
...  
Keyword(s):  
Wound Healing ◽  
Growth Factors ◽  
Energy Metabolism ◽  
Metabolic Regulation ◽  
Platelet Rich Plasma ◽  
Maxillofacial Surgery ◽  
Dermal Fibroblasts ◽  
Metabolic Reprogramming ◽  
Metabolic Effects ◽  
Oral And Maxillofacial Surgery

As a source of growth factors for expediting wound healing and tissue regeneration, plasma-rich plasma (PRP) has been extensively applied in diverse fields including orthopaedics, ophthalmology, oral and maxillofacial surgery, dentistry, and gynaecology. However, the function of PRP in metabolic regulations remains enigmatic. A standardized method was devised herein to enrich growth factors and to lyophilize it as enhanced PRP (ePRP) powder, which could become ubiquitously available without mechanical centrifugation in clinical practice. To identify metabolic reprogramming in human dermal fibroblasts under ePRP treatment, putative metabolic targets were identified by transcriptome profiling and validated for their metabolic effects and mechanism. ePRP does not only promote wound healing but re-aligns energy metabolism by shifting to glycolysis through stimulation of glycolytic enzyme activity in fibroblasts. On the contrary, oxygen consumption rates and several mitochondrial respiration activities were attenuated in ePRP-treated fibroblasts. Furthermore, ePRP treatment drives the mitochondrial resetting by hindering the mitochondrial biogenesis-related genes and results in a dampened mitochondrial mass. Antioxidant production was further increased by ePRP treatment to prevent reactive oxygen species formation. Besides, ePRP also halts the senescence progression of fibroblasts by activating SIRT1 expression. Importantly, the glycolytic inhibitor 2-DG can completely reverse the ePRP-enhanced wound healing capacity, whereas the mitochondrial inhibitor oligomycin cannot. This is the first study to utilize PRP for comprehensively investigating its effects on the metabolic reprogramming of fibroblasts. These findings indicate that PRP’s primary metabolic regulation is to promote metabolic reprogramming toward glycolytic energy metabolism in fibroblasts, preserving redox equilibrium and allowing anabolic pathways necessary for the healing and anti-ageing process.

Sign in / Sign up

Export Citation Format

Share Document