A fatal case of healthcare associated Crimean-Congo haemorrhagic fever with severe disease and multi-organ failure

2016 ◽  
Vol 72 (2) ◽  
pp. 253-255 ◽  
Author(s):  
Mustafa Sunbul ◽  
Saban Esen ◽  
Tom E. Fletcher ◽  
Ahmet Dilek ◽  
Nil Guler ◽  
...  
Keyword(s):  
Organ Failure ◽  
Severe Disease ◽  
Fatal Case ◽  
Haemorrhagic Fever ◽  
Multi Organ Failure ◽  
Crimean Congo Haemorrhagic Fever ◽  
Healthcare Associated

scholarly journals A Fatal Case of Healthcare Associated Crimean-Congo Haemorrhagic Fever With Severe Disease And Multiple Complications

2015 ◽  
Vol 2 (suppl_1) ◽  
Author(s):  
Mustafa Sunbul ◽  
Saban Esen ◽  
Tom Fletcher ◽  
Ahmet Dilek ◽  
Nil Guler ◽  
...  
Keyword(s):  
Severe Disease ◽  
Fatal Case ◽  
Haemorrhagic Fever ◽  
Crimean Congo Haemorrhagic Fever ◽  
Healthcare Associated

scholarly journals Non-fatal case of Crimean-Congo haemorrhagic fever imported into the United Kingdom (ex Bulgaria), June 2014

2014 ◽  
Vol 19 (30) ◽  
Author(s):  
S Lumley ◽  
B Atkinson ◽  
S D Dowall ◽  
J K Pitman ◽  
S Staplehurst ◽  
...  
Keyword(s):  
United Kingdom ◽  
Sequence Analysis ◽  
Eastern Europe ◽  
Symptom Onset ◽  
Severe Disease ◽  
Fatal Case ◽  
Haemorrhagic Fever ◽  
The United Kingdom ◽  
Cchf Virus ◽  
Crimean Congo Haemorrhagic Fever

Crimean-Congo haemorrhagic fever (CCHF) was diagnosed in a United Kingdom traveller who returned from Bulgaria in June 2014. The patient developed a moderately severe disease including fever, headaches and petechial rash. CCHF was diagnosed following identification of CCHF virus (CCHFV) RNA in a serum sample taken five days after symptom onset. Sequence analysis of the CCHFV genome showed that the virus clusters within the Europe 1 clade, which includes viruses from eastern Europe.

scholarly journals Haemophagocytosis in a patient with Crimean–Congo haemorrhagic fever

2007 ◽  
Vol 56 (8) ◽  
pp. 1126-1128 ◽  
Author(s):  
Atahan Cagatay ◽  
Mahir Kapmaz ◽  
Asli Karadeniz ◽  
Seniha Basaran ◽  
Mustafa Yenerel ◽  
...  
Keyword(s):  
Clinical Symptoms ◽  
Severe Disease ◽  
Case Fatality ◽  
Haemorrhagic Fever ◽  
Rt Pcr ◽  
Patient History ◽  
Endemic Region ◽  
Cchf Virus ◽  
History Of ◽  
Crimean Congo Haemorrhagic Fever

Crimean–Congo haemorrhagic fever (CCHF) is a severe disease with a case fatality of 2.8 to 80 %. A patient dwelling in an endemic region for CCHF was admitted with fever preceding bleeding diathesis and pancytopenia. Despite no history of tick exposure, CCHF was highly suspected. With an oral ribavirin therapy, clinical and laboratory improvements were obtained. The diagnosis was confirmed by detection of IgM antibody to CCHF virus and positive RT-PCR. Although the main pathogenesis of CCHF infection is not elucidated yet, haemophagocytosis, a symptom rarely reported in viral haemorrhagic fevers, was observed in this case. Haemophagocytosis is suggested to have a role in the development of pancytopenia in CCHF, the mechanism of which still needs to be investigated, probably with cytokine studies. Together with clinical symptoms and patient history, haemophagocytosis may be an indicator for CCHF.

Could Australian ticks harbour emerging viral pathogens?

2018 ◽  
Vol 39 (4) ◽  
pp. 185
Author(s):  
Caitlin A O'Brien ◽  
Roy A Hall ◽  
Ala Lew-Tabor
Keyword(s):  
Disease Burden ◽  
Severe Disease ◽  
Haemorrhagic Fever ◽  
Human Pathogens ◽  
Viral Pathogens ◽  
Tick Borne Encephalitis ◽  
The Us ◽  
Crimean Congo Haemorrhagic Fever ◽  
Tick Borne Encephalitis Virus ◽  
Severe Fever

Tick-borne viruses contribute significantly to the disease burden in Europe, Asia and the US. Historically, some of the most well-known viruses from this group include the human pathogens, tick-borne encephalitis virus and Crimean-Congo haemorrhagic fever virus. More recently multiple emerging tick-borne viruses have been associated with severe disease in humans with Bourbon virus and Heartland virus isolated from patients in the US and severe fever with thrombocytopenia syndrome virus reported from China, Japan, and South Korea. Such examples highlight the need for broader approaches to survey arthropod pathogens, to encompass not only known but novel pathogens circulating in Australian tick populations.

scholarly journals A fatal case of multi-organ failure in acute yellow phosphorus poisoning

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Jai Prakash Soni ◽  
Pankaj Suresh Ghormade ◽  
Swapnil Akhade ◽  
Krishnadutt Chavali ◽  
Bedanta Sarma
Keyword(s):  
Organ Failure ◽  
Fatal Case ◽  
Phosphorus Poisoning ◽  
Multi Organ Failure ◽  
Yellow Phosphorus

scholarly journals A fatal case of psittacosis in Slovakia, January 2006

2007 ◽  
Vol 12 (31) ◽  
Author(s):  
E Kovácová ◽  
J Majtán ◽  
R Botek ◽  
T Bokor ◽  
H Blaškovicová ◽  
...  
Keyword(s):  
Organ Failure ◽  
Fatal Case ◽  
Multi Organ Failure ◽  
Exotic Birds

We describe a fatal case of psittacosis in a pet shop worker in Slovakia, who probably contracted the disease from exotic birds. The patient showed first symptoms in December 2005 and died in January 2006 of irreversible shock and multi-organ failure.

scholarly journals The Integration of Human and Veterinary Studies for Better Understanding and Management of Crimean-Congo Haemorrhagic Fever

2021 ◽  
Vol 12 ◽  
Author(s):  
Ciaran Gilbride ◽  
Jack Saunders ◽  
Hannah Sharpe ◽  
Emmanuel Atangana Maze ◽  
Georgina Limon ◽  
...  
Keyword(s):  
Health Outcomes ◽  
Human Disease ◽  
Potential Application ◽  
One Health ◽  
Animal Health ◽  
Severe Disease ◽  
Zoonotic Diseases ◽  
Haemorrhagic Fever ◽  
Animal Reservoir ◽  
Crimean Congo Haemorrhagic Fever

Outbreaks that occur as a result of zoonotic spillover from an animal reservoir continue to highlight the importance of studying the disease interface between species. One Health approaches recognise the interdependence of human and animal health and the environmental interplay. Improving the understanding and prevention of zoonotic diseases may be achieved through greater consideration of these relationships, potentially leading to better health outcomes across species. In this review, special emphasis is given on the emerging and outbreak pathogen Crimean-Congo Haemorrhagic Fever virus (CCHFV) that can cause severe disease in humans. We discuss the efforts undertaken to better understand CCHF and the importance of integrating veterinary and human research for this pathogen. Furthermore, we consider the use of closely related nairoviruses to model human disease caused by CCHFV. We discuss intervention approaches with potential application for managing CCHFV spread, and how this concept may benefit both animal and human health.

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