scholarly journals A Fatal Case of Healthcare Associated Crimean-Congo Haemorrhagic Fever With Severe Disease And Multiple Complications

2015 ◽  
Vol 2 (suppl_1) ◽  
Author(s):  
Mustafa Sunbul ◽  
Saban Esen ◽  
Tom Fletcher ◽  
Ahmet Dilek ◽  
Nil Guler ◽  
...  
Keyword(s):  
Severe Disease ◽  
Fatal Case ◽  
Haemorrhagic Fever ◽  
Crimean Congo Haemorrhagic Fever ◽  
Healthcare Associated

A fatal case of healthcare associated Crimean-Congo haemorrhagic fever with severe disease and multi-organ failure

2016 ◽  
Vol 72 (2) ◽  
pp. 253-255 ◽  
Author(s):  
Mustafa Sunbul ◽  
Saban Esen ◽  
Tom E. Fletcher ◽  
Ahmet Dilek ◽  
Nil Guler ◽  
...  
Keyword(s):  
Organ Failure ◽  
Severe Disease ◽  
Fatal Case ◽  
Haemorrhagic Fever ◽  
Multi Organ Failure ◽  
Crimean Congo Haemorrhagic Fever ◽  
Healthcare Associated

scholarly journals Non-fatal case of Crimean-Congo haemorrhagic fever imported into the United Kingdom (ex Bulgaria), June 2014

2014 ◽  
Vol 19 (30) ◽  
Author(s):  
S Lumley ◽  
B Atkinson ◽  
S D Dowall ◽  
J K Pitman ◽  
S Staplehurst ◽  
...  
Keyword(s):  
United Kingdom ◽  
Sequence Analysis ◽  
Eastern Europe ◽  
Symptom Onset ◽  
Severe Disease ◽  
Fatal Case ◽  
Haemorrhagic Fever ◽  
The United Kingdom ◽  
Cchf Virus ◽  
Crimean Congo Haemorrhagic Fever

Crimean-Congo haemorrhagic fever (CCHF) was diagnosed in a United Kingdom traveller who returned from Bulgaria in June 2014. The patient developed a moderately severe disease including fever, headaches and petechial rash. CCHF was diagnosed following identification of CCHF virus (CCHFV) RNA in a serum sample taken five days after symptom onset. Sequence analysis of the CCHFV genome showed that the virus clusters within the Europe 1 clade, which includes viruses from eastern Europe.

scholarly journals Haemophagocytosis in a patient with Crimean–Congo haemorrhagic fever

2007 ◽  
Vol 56 (8) ◽  
pp. 1126-1128 ◽  
Author(s):  
Atahan Cagatay ◽  
Mahir Kapmaz ◽  
Asli Karadeniz ◽  
Seniha Basaran ◽  
Mustafa Yenerel ◽  
...  
Keyword(s):  
Clinical Symptoms ◽  
Severe Disease ◽  
Case Fatality ◽  
Haemorrhagic Fever ◽  
Rt Pcr ◽  
Patient History ◽  
Endemic Region ◽  
Cchf Virus ◽  
History Of ◽  
Crimean Congo Haemorrhagic Fever

Crimean–Congo haemorrhagic fever (CCHF) is a severe disease with a case fatality of 2.8 to 80 %. A patient dwelling in an endemic region for CCHF was admitted with fever preceding bleeding diathesis and pancytopenia. Despite no history of tick exposure, CCHF was highly suspected. With an oral ribavirin therapy, clinical and laboratory improvements were obtained. The diagnosis was confirmed by detection of IgM antibody to CCHF virus and positive RT-PCR. Although the main pathogenesis of CCHF infection is not elucidated yet, haemophagocytosis, a symptom rarely reported in viral haemorrhagic fevers, was observed in this case. Haemophagocytosis is suggested to have a role in the development of pancytopenia in CCHF, the mechanism of which still needs to be investigated, probably with cytokine studies. Together with clinical symptoms and patient history, haemophagocytosis may be an indicator for CCHF.

Could Australian ticks harbour emerging viral pathogens?

2018 ◽  
Vol 39 (4) ◽  
pp. 185
Author(s):  
Caitlin A O'Brien ◽  
Roy A Hall ◽  
Ala Lew-Tabor
Keyword(s):  
Disease Burden ◽  
Severe Disease ◽  
Haemorrhagic Fever ◽  
Human Pathogens ◽  
Viral Pathogens ◽  
Tick Borne Encephalitis ◽  
The Us ◽  
Crimean Congo Haemorrhagic Fever ◽  
Tick Borne Encephalitis Virus ◽  
Severe Fever

Tick-borne viruses contribute significantly to the disease burden in Europe, Asia and the US. Historically, some of the most well-known viruses from this group include the human pathogens, tick-borne encephalitis virus and Crimean-Congo haemorrhagic fever virus. More recently multiple emerging tick-borne viruses have been associated with severe disease in humans with Bourbon virus and Heartland virus isolated from patients in the US and severe fever with thrombocytopenia syndrome virus reported from China, Japan, and South Korea. Such examples highlight the need for broader approaches to survey arthropod pathogens, to encompass not only known but novel pathogens circulating in Australian tick populations.

scholarly journals The Integration of Human and Veterinary Studies for Better Understanding and Management of Crimean-Congo Haemorrhagic Fever

2021 ◽  
Vol 12 ◽  
Author(s):  
Ciaran Gilbride ◽  
Jack Saunders ◽  
Hannah Sharpe ◽  
Emmanuel Atangana Maze ◽  
Georgina Limon ◽  
...  
Keyword(s):  
Health Outcomes ◽  
Human Disease ◽  
Potential Application ◽  
One Health ◽  
Animal Health ◽  
Severe Disease ◽  
Zoonotic Diseases ◽  
Haemorrhagic Fever ◽  
Animal Reservoir ◽  
Crimean Congo Haemorrhagic Fever

Outbreaks that occur as a result of zoonotic spillover from an animal reservoir continue to highlight the importance of studying the disease interface between species. One Health approaches recognise the interdependence of human and animal health and the environmental interplay. Improving the understanding and prevention of zoonotic diseases may be achieved through greater consideration of these relationships, potentially leading to better health outcomes across species. In this review, special emphasis is given on the emerging and outbreak pathogen Crimean-Congo Haemorrhagic Fever virus (CCHFV) that can cause severe disease in humans. We discuss the efforts undertaken to better understand CCHF and the importance of integrating veterinary and human research for this pathogen. Furthermore, we consider the use of closely related nairoviruses to model human disease caused by CCHFV. We discuss intervention approaches with potential application for managing CCHFV spread, and how this concept may benefit both animal and human health.

Crimean-Congo haemorrhagic fever - the emerging vector-borne disease

2008 ◽  
Vol 63 (4) ◽  
pp. 1-7
Author(s):  
Krzysztof Kostro ◽  
Dorota Luft-Deptuła ◽  
Zdzisław Gliński
Keyword(s):  
Haemorrhagic Fever ◽  
Vector Borne Disease ◽  
Crimean Congo Haemorrhagic Fever ◽  
Vector Borne

scholarly journals Knowledge, attitude and perceptions about Crimean Congo Haemorrhagic Fever (CCHF) among occupationally high-risk healthcare professionals of Pakistan

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Ali Ahmed ◽  
Muhammad Saqlain ◽  
Maria Tanveer ◽  
Azhar Hussain Tahir ◽  
Fakhar Ud-Din ◽  
...  
Keyword(s):  
At Risk ◽  
Health Care Professionals ◽  
Work Experience ◽  
Tertiary Care ◽  
Nosocomial Transmission ◽  
Haemorrhagic Fever ◽  
Sources Of Information ◽  
Validated Questionnaire ◽  
Low Middle Income Countries ◽  
Crimean Congo Haemorrhagic Fever

Abstract Background Crimean Congo Haemorrhagic Fever (CCHF), a tropically neglected infectious disease caused by Nairovirus, is endemic in low middle-income countries like Pakistan. Emergency health care professionals (HCPs) are at risk of contracting nosocomial transmission of CCHF. We, therefore, aim to analyze the knowledge, attitudes, and perceptions (KAP) of at-risk physicians, nurses, and pharmacists in Pakistan and the factors associated with good KAP. Method A validated questionnaire (Cronbach’s alpha 0.71) was used to collect data from HCPs in two CCHF endemic metropolitan cities of Pakistan by employing a cross-sectional study design. For data analysis percentages, chi-square test and Spearman correlation were applied by using SPSS version 22. Results Of the 478 participants, 56% (n = 268) were physicians, 37.4% (n = 179) were nurses, and 6.5% (n = 31) were pharmacists. The proportion of HCPs with good knowledge, attitude, and perception scores was 54.3%, 81, and 69%, respectively. Being a physician, having more work experience, having a higher age, working in tertiary care settings, were key factors for higher knowledge (p < 0.001). The correlation coefficient showed significant positive correlation between attitude- perception (r = 0.560, p < 0.001). Conclusion We have observed average knowledge of HCPs. Therefore, we recommend time to time education campaigns and workshops in highly endemic CCHF regions to be launched by health ministries and HCPs, in particular nurses, encouraged to follow authentic academic sources of information to prevent nosocomial transmission.

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