scholarly journals Non-fatal case of Crimean-Congo haemorrhagic fever imported into the United Kingdom (ex Bulgaria), June 2014

2014 ◽  
Vol 19 (30) ◽  
Author(s):  
S Lumley ◽  
B Atkinson ◽  
S D Dowall ◽  
J K Pitman ◽  
S Staplehurst ◽  
...  
Keyword(s):  
United Kingdom ◽  
Sequence Analysis ◽  
Eastern Europe ◽  
Symptom Onset ◽  
Severe Disease ◽  
Fatal Case ◽  
Haemorrhagic Fever ◽  
The United Kingdom ◽  
Cchf Virus ◽  
Crimean Congo Haemorrhagic Fever

Crimean-Congo haemorrhagic fever (CCHF) was diagnosed in a United Kingdom traveller who returned from Bulgaria in June 2014. The patient developed a moderately severe disease including fever, headaches and petechial rash. CCHF was diagnosed following identification of CCHF virus (CCHFV) RNA in a serum sample taken five days after symptom onset. Sequence analysis of the CCHFV genome showed that the virus clusters within the Europe 1 clade, which includes viruses from eastern Europe.

scholarly journals Molecular epidemiology of Crimean-Congo haemorrhagic fever virus in India

2016 ◽  
Vol 144 (16) ◽  
pp. 3422-3425 ◽  
Author(s):  
P. SINGH ◽  
M. CHHABRA ◽  
P. SHARMA ◽  
R. JAISWAL ◽  
G. SINGH ◽  
...  
Keyword(s):  
Eastern Europe ◽  
N Gene ◽  
Western India ◽  
Haemorrhagic Fever ◽  
Rt Pcr ◽  
Study Region ◽  
Phylogenetic Relatedness ◽  
Cchf Virus ◽  
Crimean Congo Haemorrhagic Fever ◽  
First Time

SUMMARYCrimean-Congo haemorrhagic fever (CCHF) is an emerging zoonotic disease in India which is prevalent in neighbouring countries. CCHF virus (CCHFV) is a widespread tick-borne virus which is endemic in Africa, Asia, Eastern Europe and the Middle East. In the present study, samples of clinically suspected human cases from different areas of northern-western India were tested for the presence of CCHFV by RT–PCR through amplification of nucleocapsid (N) gene of CCHFV. Positive samples were sequenced to reveal the prevailing CCHFV genotype(s) and phylogenetic relatedness. A phylogenetic tree revealed the emergence of diverse strains in the study region showing maximum identity with the Pakistan, Afghanistan and Iran strains, which was different from earlier reported Indian strains. Our findings reveal for the first time the emergence of the Asia 1 group in India; while earlier reported CCHFV strains belong to the Asia 2 group.

scholarly journals Haemophagocytosis in a patient with Crimean–Congo haemorrhagic fever

2007 ◽  
Vol 56 (8) ◽  
pp. 1126-1128 ◽  
Author(s):  
Atahan Cagatay ◽  
Mahir Kapmaz ◽  
Asli Karadeniz ◽  
Seniha Basaran ◽  
Mustafa Yenerel ◽  
...  
Keyword(s):  
Clinical Symptoms ◽  
Severe Disease ◽  
Case Fatality ◽  
Haemorrhagic Fever ◽  
Rt Pcr ◽  
Patient History ◽  
Endemic Region ◽  
Cchf Virus ◽  
History Of ◽  
Crimean Congo Haemorrhagic Fever

Crimean–Congo haemorrhagic fever (CCHF) is a severe disease with a case fatality of 2.8 to 80 %. A patient dwelling in an endemic region for CCHF was admitted with fever preceding bleeding diathesis and pancytopenia. Despite no history of tick exposure, CCHF was highly suspected. With an oral ribavirin therapy, clinical and laboratory improvements were obtained. The diagnosis was confirmed by detection of IgM antibody to CCHF virus and positive RT-PCR. Although the main pathogenesis of CCHF infection is not elucidated yet, haemophagocytosis, a symptom rarely reported in viral haemorrhagic fevers, was observed in this case. Haemophagocytosis is suggested to have a role in the development of pancytopenia in CCHF, the mechanism of which still needs to be investigated, probably with cytokine studies. Together with clinical symptoms and patient history, haemophagocytosis may be an indicator for CCHF.

scholarly journals Crimean-Congo haemorrhagic fever in a Greek worker returning from Bulgaria, June 2018

2018 ◽  
Vol 23 (35) ◽  
Author(s):  
Anna Papa ◽  
Filothei Markatou ◽  
Helena C. Maltezou ◽  
Elpida Papadopoulou ◽  
Eirini Terzi ◽  
...  
Keyword(s):  
Mental Status ◽  
Virus Strain ◽  
Symptom Onset ◽  
Altered Mental Status ◽  
Haemodynamic Instability ◽  
Severe Thrombocytopenia ◽  
Supportive Treatment ◽  
Haemorrhagic Fever ◽  
Cchf Virus ◽  
Crimean Congo Haemorrhagic Fever

We report a tick-borne case of severe Crimean-Congo haemorrhagic fever (CCHF) imported into Greece from Bulgaria. The patient presented severe thrombocytopenia, hemophagocytosis, haemodynamic instability, large haematomas and altered mental status. Supportive treatment and ribavirin were administered. Symptoms started one day after the tick was removed; the patient was discharged from the hospital 26 days after symptom onset. No secondary cases were observed. Phylogenetically the CCHF virus strain belongs to clade Europe 1.

A fatal case of healthcare associated Crimean-Congo haemorrhagic fever with severe disease and multi-organ failure

2016 ◽  
Vol 72 (2) ◽  
pp. 253-255 ◽  
Author(s):  
Mustafa Sunbul ◽  
Saban Esen ◽  
Tom E. Fletcher ◽  
Ahmet Dilek ◽  
Nil Guler ◽  
...  
Keyword(s):  
Organ Failure ◽  
Severe Disease ◽  
Fatal Case ◽  
Haemorrhagic Fever ◽  
Multi Organ Failure ◽  
Crimean Congo Haemorrhagic Fever ◽  
Healthcare Associated

scholarly journals A Fatal Case of Healthcare Associated Crimean-Congo Haemorrhagic Fever With Severe Disease And Multiple Complications

2015 ◽  
Vol 2 (suppl_1) ◽  
Author(s):  
Mustafa Sunbul ◽  
Saban Esen ◽  
Tom Fletcher ◽  
Ahmet Dilek ◽  
Nil Guler ◽  
...  
Keyword(s):  
Severe Disease ◽  
Fatal Case ◽  
Haemorrhagic Fever ◽  
Crimean Congo Haemorrhagic Fever ◽  
Healthcare Associated

scholarly journals Sequencing and phylogenetic characterisation of a fatal Crimean – Congo haemorrhagic fever case imported into the United Kingdom, October 2012

2012 ◽  
Vol 17 (48) ◽  
Author(s):  
B Atkinson ◽  
J Latham ◽  
J Chamberlain ◽  
C Logue ◽  
L O'Donoghue ◽  
...  
Keyword(s):  
United Kingdom ◽  
Haemorrhagic Fever ◽  
Fever Case ◽  
Binary File ◽  
The United Kingdom ◽  
Crimean Congo Haemorrhagic Fever

Binary file ES_Abstracts_Final_ECDC.txt matches

scholarly journals Viraemic transmission of Crimean-Congo haemorrhagic fever virus to ticks

1991 ◽  
Vol 106 (2) ◽  
pp. 373-382 ◽  
Author(s):  
A. J. Shepherd ◽  
R. Swanepoel ◽  
S. P. Shepherd ◽  
P. A. Leman ◽  
O. Mathee
Keyword(s):  
Ixodid Tick ◽  
Transovarial Transmission ◽  
Haemorrhagic Fever ◽  
Transmitted Infection ◽  
Hyalomma Truncatum ◽  
Virus Content ◽  
Cchf Virus ◽  
Rhipicephalus Evertsi Evertsi ◽  
Crimean Congo Haemorrhagic Fever ◽  
Tick Vectors

SUMMARYIn order to determine the way in which vertebrates infected with Crimean-Congo haemorrhagic fever (CCHF) virus and potential ixodid tick vectors interact in nature, immature and adult ticks of several species were fed on viraemic mammals and then assayed for virus content at varying times after feeding. CCHF virus was not isolated from ticks of six species tested after feeding as adults and immature forms on sheep with viraemia of 102·5−3·2LD 50/ml, nor from larval ticks fed on guinea-pigs and white-tailed rats with viraemia of 101·9−2·7LD 50/ml. In contrast, virus was isolated from 10 of 152 pools of engorged adult ticks of 5 species that fed on cattle with viraemia of 101·5−2·7LD 50/ml and from 3 of 137 female ticks after oviposition. Infection was transmitted to larval and nymphalHyalomma truncatumandH. marginatum rufipes, but not toRhipicephalus evertsi evertsi, from a scrub hare with viraemia of 104·250/ml but only nymphalH. truncatumandH. m. rufipesbecame infected from scrub hares with viraemia of 102·6−2·7LD 50/ml. Infection was transmitted trans-stadially inH. m. rufipesandH. truncatuminfected as nymphae, and adultH. m. rufipestransmitted infection to a sheep. No evidence of transovarial transmission was found in larval progeny of ticks exposed to CCHF virus as adults on sheep and cattle or as immatures on scrub hares.

scholarly journals Modelling Ranavirus Transmission in Populations of Common Frogs (Rana temporaria) in the United Kingdom

Viruses ◽  
2019 ◽  
Vol 11 (6) ◽  
pp. 556 ◽  
Author(s):  
Amanda L.J. Duffus ◽  
Trenton W.J. Garner ◽  
Richard A. Nichols ◽  
Joshua P. Standridge ◽  
Julia E. Earl
Keyword(s):  
United Kingdom ◽  
Rana Temporaria ◽  
Severe Disease ◽  
Preliminary Investigation ◽  
Population Decline ◽  
Disease Dynamics ◽  
Amphibian Disease ◽  
The United Kingdom ◽  
Infection Dynamics ◽  
Si Model

Ranaviruses began emerging in common frogs (Rana temporaria) in the United Kingdom in the late 1980s and early 1990s, causing severe disease and declines in the populations of these animals. Herein, we explored the transmission dynamics of the ranavirus(es) present in common frog populations, in the context of a simple susceptible-infected (SI) model, using parameters derived from the literature. We explored the effects of disease-induced population decline on the dynamics of the ranavirus. We then extended the model to consider the infection dynamics in populations exposed to both ulcerative and hemorrhagic forms of the ranaviral disease. The preliminary investigation indicated the important interactions between the forms. When the ulcerative form was present in a population and the hemorrhagic form was later introduced, the hemorrhagic form of the disease needed to be highly contagious, to persist. We highlighted the areas where further research and experimental evidence is needed and hope that these models would act as a guide for further research into the amphibian disease dynamics.

Crimean-Congo haemorrhagic fever outbreak in Middle Anatolia: a multicentre study of clinical features and outcome measures

2005 ◽  
Vol 54 (4) ◽  
pp. 385-389 ◽  
Author(s):  
Mehmet Bakir ◽  
Mehmet Ugurlu ◽  
Basak Dokuzoguz ◽  
Hurrem Bodur ◽  
Mehmet A Tasyaran ◽  
...  
Keyword(s):  
Chart Review ◽  
Tertiary Care ◽  
Fatal Outcome ◽  
Hospital Costs ◽  
Retrospective Chart Review ◽  
Haemorrhagic Fever ◽  
Related Data ◽  
Cchf Virus ◽  
Crimean Congo Haemorrhagic Fever ◽  
Tertiary Care Hospitals

A Crimean-Congo haemorrhagic fever (CCHF) outbreak emerged from 2001 to 2003 in the Middle Anatolia region of Turkey. This study describes the clinical characteristics and outcome features of CCHF patients admitted to four tertiary care hospitals in Turkey. Definitive diagnosis was based on the detection of CCHF virus-specific IgM by ELISA or of genomic segments of the CCHF virus by RT-PCR. Related data were collected by a retrospective chart review. Hospital costs were extracted from the final discharge bills. Univariate and multivariate analyses were conducted to determine the independent predictors of mortality. CCHF virus-specific antibodies or genomic segments were detected in the sera of 99 cases. Seven cases that were treated with ribavirin were excluded from the study. Cases were mostly farmers (83 cases, 90 %), and 60 % had a tick-bite history before the onset of fever. Impaired consciousness and splenomegaly were independent predictors of a fatal outcome.

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