Ru complexes containing Cp, mPTA and natural purine bases (mPTA = methyl-N-1,3,5-triaza-7-phosphaadamantane): Evaluation of their antiproliferative activity, solubility and redox properties

New Ru complexes are described that have the potential to interact with DNA in the three ways shown and this may be the reason why some of these complexes have such high antiproliferative activity.

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Antipsoriatic Anthrones with Modulated Redox Properties. 2. Novel Derivatives of Chrysarobin and Isochrysarobin-Antiproliferative Activity and 5-Lipoxygenase Inhibition

Journal of Medicinal Chemistry ◽

10.1021/jm00037a017 ◽

1994 ◽

Vol 37 (11) ◽

pp. 1660-1669 ◽

Cited By ~ 34

Author(s):

Klaus Mueller ◽

Peter Leukel ◽

Klaus Ziereis ◽

Ingo Gawlik

Keyword(s):

Antiproliferative Activity ◽

Redox Properties ◽

Lipoxygenase Inhibition ◽

Derivatives Of

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Structure−Activity Relationships for NAMI-A-type Complexes (HL)[trans-RuCl4L(S-dmso)ruthenate(III)] (L = Imidazole, Indazole, 1,2,4-Triazole, 4-Amino-1,2,4-triazole, and 1-Methyl-1,2,4-triazole): Aquation, Redox Properties, Protein Binding, and Antiproliferative Activity

Journal of Medicinal Chemistry ◽

10.1021/jm061081y ◽

2007 ◽

Vol 50 (9) ◽

pp. 2185-2193 ◽

Cited By ~ 161

Author(s):

Michael Groessl ◽

Erwin Reisner ◽

Christian G. Hartinger ◽

Rene Eichinger ◽

Olga Semenova ◽

...

Keyword(s):

Protein Binding ◽

Antiproliferative Activity ◽

Redox Properties ◽

Structure Activity Relationships ◽

Structure Activity

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Natural-Antioxidant-Inspired Benzo[b]selenophenes: Synthesis, Redox Properties, and Antiproliferative Activity

Chemistry - An Asian Journal ◽

10.1002/asia.201600472 ◽

2016 ◽

Vol 11 (13) ◽

pp. 1929-1938 ◽

Cited By ~ 13

Author(s):

Edgars Paegle ◽

Ilona Domracheva ◽

Baiba Turovska ◽

Marina Petrova ◽

Iveta Kanepe-Lapsa ◽

...

Keyword(s):

Antiproliferative Activity ◽

Redox Properties ◽

Natural Antioxidant

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High Antiproliferative Activity of Hydroxythiopyridones over Hydroxypyridones and Their Organoruthenium Complexes

Biomedicines ◽

10.3390/biomedicines9020123 ◽

2021 ◽

Vol 9 (2) ◽

pp. 123

Author(s):

Md. Salman Shakil ◽

Shahida Parveen ◽

Zohaib Rana ◽

Fearghal Walsh ◽

Sanam Movassaghi ◽

...

Keyword(s):

Lung Cancer ◽

Cell Cycle ◽

Cancer Cells ◽

Antiproliferative Activity ◽

Molecular Structures ◽

Cell Cycle Distribution ◽

Important Class ◽

X Ray Diffraction ◽

X Ray ◽

Ru Complexes

Hydroxypyr(id)ones are a pharmaceutically important class of compounds that have shown potential in diverse areas of drug discovery. We investigated the 3-hydroxy-4-pyridones 1a–1c and 3-hydroxy-4-thiopyridones 1d–1f as well as their Ru(η6-p-cymene)Cl complexes 2a–2f, and report here the molecular structures of 1b and 1d as determined by X-ray diffraction analysis. Detailed cell biological investigations revealed potent cytotoxic activity, in particular of the 3-hydroxy-4-thiopyridones 1d–1f, while the Ru complexes of both compound types were less potent, despite still showing antiproliferative activity in the low μM range. The compounds did not modulate the cell cycle distribution of cancer cells but were cytostatic in A549 and cytotoxic in NCI-H522 non-small lung cancer cells, among other effects on cancer cells.

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Water soluble palladium(ii) and platinum(ii) acyclic diaminocarbene complexes: solution behavior, DNA binding, and antiproliferative activity

New Journal of Chemistry ◽

10.1039/d0nj00060d ◽

2020 ◽

Vol 44 (15) ◽

pp. 5762-5773 ◽

Cited By ~ 1

Author(s):

Tatiyana V. Serebryanskaya ◽

Mikhail A. Kinzhalov ◽

Vladimir Bakulev ◽

Georgii Alekseev ◽

Anastasiya Andreeva ◽

...

Keyword(s):

Dna Binding ◽

Antiproliferative Activity ◽

Water Soluble ◽

Solution Behavior ◽

Antitumor Potential ◽

Acyclic Diaminocarbene

Water soluble Pd(ii) and Pt(ii)–ADC species synthesized via the metal-mediated coupling of isocyanides and 1,2-diaminobenzene have demonstrated antitumor potential.

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