Gallotannin mediated silver colloidal nanoparticles as multifunctional nano platform: Rapid colorimetric and turn-on fluorescent sensor for Hg2+, catalytic and In vitro anticancer activities

2019 ◽  
Vol 206 ◽  
pp. 624-633 ◽  
Author(s):  
Prasad G. Mahajan ◽  
Nilam C. Dige ◽  
Balasaheb D. Vanjare ◽  
Abdul Rehman Phull ◽  
Song Ja Kim ◽  
...  
Keyword(s):  
Fluorescent Sensor ◽  
Colloidal Nanoparticles ◽  
Anticancer Activities ◽  
Turn On ◽  
Silver Colloidal Nanoparticles

scholarly journals Development of a fused imidazo[1,2-a]pyridine based fluorescent probe for Fe3+ and Hg2+ in aqueous media and HeLa cells

RSC Advances ◽  
2019 ◽  
Vol 9 (51) ◽  
pp. 29856-29863 ◽  
Author(s):  
Suman Srivastava ◽  
Neha Thakur ◽  
Ashutosh Singh ◽  
Poonam Shukla ◽  
Vipin Kumar Maikhuri ◽  
...  
Keyword(s):  
Fluorescent Probe ◽  
Hela Cells ◽  
Fluorescent Sensor ◽  
Aqueous Media ◽  
Selective Detection ◽  
Cascade Cyclization ◽  
Turn On ◽  
Highly Sensitive

A new fluorescent sensor 5 having fused imidazopyridine scaffold has been synthesized via cascade cyclization. It exhibits highly sensitive and selective detection of Fe3+ (‘turn-on’) and Hg2+ (‘turn-off’) in vitro and in HeLa cells.

scholarly journals Evaluation of Flexural Strength of Polymethyl Methacrylate modified with Silver Colloidal Nanoparticles subjected to Two Different Curing Cycles: An in vitro Study

2018 ◽  
Vol 19 (3) ◽  
pp. 262-268
Author(s):  
LM Ranganath ◽  
Ajay Gaikwad ◽  
Saket K Jain ◽  
Kapil S Pal
Keyword(s):  
Flexural Strength ◽  
Base Material ◽  
Control Group ◽  
Colloidal Nanoparticles ◽  
Denture Base ◽  
Base Resin ◽  
The Mean ◽  
Silver Colloidal Nanoparticles ◽  
Denture Base Resin

ABSTRACT Aim Silver colloidal nanoparticles have been incorporated into acrylic resins to induce antimicrobial properties. However, as additives, they can influence the mechanical properties of the final product. Mechanical properties are also dependent on different curing cycles. The aim of this study was to evaluate flexural strength of a denture base resin incorporated with different concentrations of silver colloidal nanoparticles subjected to two different curing cycles. Materials and methods Lucitone 199 denture base resin was used into which silver colloidal nanoparticles were incorporated at 0.5 and 5% by polymer mass. Specimens devoid of nanoparticles were used as controls. A total of 60 specimens were fabricated and divided into two groups. Each group was divided into three subgroups consisting of 10 specimens each. The specimens were fabricated according to American Dental Association (ADA) specification No. 12 and tested for flexural strength using universal testing machine. Results Silver colloidal nanoparticle incorporation at 0.5% concentration increased the mean flexural strength in both curing cycles by 7.5 and 4.4%, respectively, when compared with the control group. Conclusion The study suggested that the mean flexural strength value of 0.5% silver colloidal nanoparticles in denture base resin was above the value of the control group both in short and long curing cycles, which makes it clinically suitable as a denture base material. However, at 5% concentration, the statistically significant amount of decrease in flexural strength compared with the value of control group both in short and long curing cycles gives it a questionable prognosis. Clinical significance The specimens incorporated with the antimicrobial agent 0.5% silver colloidal nanoparticles and processed by long curing cycles showed significant increase in its flexural strength compared with the control group, which makes it clinically suitable as a denture base material. How to cite this article Munikamaiah RL, Jain SK, Pal KS, Gaikwad A. Evaluation of Flexural Strength of Polymethyl Methacrylate modified with Silver Colloidal Nanoparticles subjected to Two Different Curing Cycles: An in vitro Study. J Contemp Dent Pract 2018;19(3):262-268.

A NIR Turn-on Fluorescent Sensor For Detection of Chloride Ions in vitro and in vivo

2020 ◽  
Vol 228 ◽  
pp. 117729
Author(s):  
Fengyuan Zhang ◽  
Chen Ma ◽  
Zhijuan Jiao ◽  
Shuai Mu ◽  
Yida Zhang ◽  
...  
Keyword(s):  
Fluorescent Sensor ◽  
Chloride Ions ◽  
Turn On

Nanocurcumin: A Double-Edged Sword for Microcancers

2020 ◽  
Vol 26 (45) ◽  
pp. 5783-5792
Author(s):  
Kholood Abid Janjua ◽  
Adeeb Shehzad ◽  
Raheem Shahzad ◽  
Salman Ul Islam ◽  
Mazhar Ul Islam
Keyword(s):  
Intracellular Signaling ◽  
Dosage Forms ◽  
The Body ◽  
In Vivo Studies ◽  
Mrna Levels ◽  
Anticancer Activities ◽  
Road Map ◽  
Anticancer Effects

There is compelling evidence that drug molecules isolated from natural sources are hindered by low systemic bioavailability, poor absorption, and rapid elimination from the human body. Novel approaches are urgently needed that could enhance the retention time as well as the efficacy of natural products in the body. Among the various adopted approaches to meet this ever-increasing demand, nanoformulations show the most fascinating way of improving the bioavailability of dietary phytochemicals through modifying their pharmacokinetics and pharmacodynamics. Curcumin, a yellowish pigment isolated from dried ground rhizomes of turmeric, exhibits tremendous pharmacological effects, including anticancer activities. Several in vitro and in vivo studies have shown that curcumin mediates anticancer effects through the modulation (upregulation and/or downregulations) of several intracellular signaling pathways both at protein and mRNA levels. Scientists have introduced multiple modern techniques and novel dosage forms for enhancing the delivery, bioavailability, and efficacy of curcumin in the treatment of various malignancies. These novel dosage forms include nanoparticles, liposomes, micelles, phospholipids, and curcumin-encapsulated polymer nanoparticles. Nanocurcumin has shown improved anticancer effects compared to conventional curcumin formulations. This review discusses the underlying molecular mechanism of various nanoformulations of curcumin for the treatment of different cancers. We hope that this study will make a road map for preclinical and clinical investigations of cancer and recommend nano curcumin as a drug of choice for cancer therapy.

Novel physiological properties of ethanol extracts from Eremurus chinensis Fedtsch. roots: in vitro antioxidant and anticancer activities

2012 ◽  
Vol 3 (12) ◽  
pp. 1310 ◽  
Author(s):  
Haifang Xiao ◽  
Yutang Wang ◽  
Qisen Xiang ◽  
Chunxia Xiao ◽  
Li Yuan ◽  
...  
Keyword(s):  
Anticancer Activities ◽  
Physiological Properties ◽  
Ethanol Extracts ◽  
Roots In Vitro

scholarly journals Plant-Derived Nano and Microvesicles for Human Health and Therapeutic Potential in Nanomedicine

Pharmaceutics ◽  
2021 ◽  
Vol 13 (4) ◽  
pp. 498
Author(s):  
Mariaevelina Alfieri ◽  
Antonietta Leone ◽  
Alfredo Ambrosone
Keyword(s):  
Therapeutic Potential ◽  
Biological Activities ◽  
Plant Biotechnology ◽  
Bioactive Metabolites ◽  
Anticancer Activities ◽  
Long Distance ◽  
In Vivo Models ◽  
Therapeutic Tools

Plants produce different types of nano and micro-sized vesicles. Observed for the first time in the 60s, plant nano and microvesicles (PDVs) and their biological role have been inexplicably under investigated for a long time. Proteomic and metabolomic approaches revealed that PDVs carry numerous proteins with antifungal and antimicrobial activity, as well as bioactive metabolites with high pharmaceutical interest. PDVs have also been shown to be also involved in the intercellular transfer of small non-coding RNAs such as microRNAs, suggesting fascinating mechanisms of long-distance gene regulation and horizontal transfer of regulatory RNAs and inter-kingdom communications. High loading capacity, intrinsic biological activities, biocompatibility, and easy permeabilization in cell compartments make plant-derived vesicles excellent natural or bioengineered nanotools for biomedical applications. Growing evidence indicates that PDVs may exert anti-inflammatory, anti-oxidant, and anticancer activities in different in vitro and in vivo models. In addition, clinical trials are currently in progress to test the effectiveness of plant EVs in reducing insulin resistance and in preventing side effects of chemotherapy treatments. In this review, we concisely introduce PDVs, discuss shortly their most important biological and physiological roles in plants and provide clues on the use and the bioengineering of plant nano and microvesicles to develop innovative therapeutic tools in nanomedicine, able to encompass the current drawbacks in the delivery systems in nutraceutical and pharmaceutical technology. Finally, we predict that the advent of intense research efforts on PDVs may disclose new frontiers in plant biotechnology applied to nanomedicine.

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