Preparation of the narrow size distribution USPIO in mesoporous silica for magnetic field guided drug delivery and release

2015 ◽  
Vol 374 ◽  
pp. 96-102 ◽  
Author(s):  
B. Zapotoczny ◽  
N. Guskos ◽  
J.J. Kozioł ◽  
M.R. Dudek
Keyword(s):  
Magnetic Field ◽  
Drug Delivery ◽  
Mesoporous Silica ◽  
Size Distribution ◽  
Narrow Size Distribution

Fabrication of mesoporous silica nanospheres with radially oriented mesochannels by microemulsion templating for adsorption and controlled release of aspirin

RSC Advances ◽  
2015 ◽  
Vol 5 (9) ◽  
pp. 6599-6606 ◽  
Author(s):  
Jinli Pang ◽  
Xiuyan Li ◽  
Guowei Zhou ◽  
Bin Sun ◽  
Yingqin Wei
Keyword(s):  
Controlled Release ◽  
Mesoporous Silica ◽  
Size Distribution ◽  
Microemulsion System ◽  
Narrow Size Distribution ◽  
Silica Nanospheres ◽  
Mesoporous Silica Nanospheres

The MSN spheres with narrow size distribution and radially oriented mesoporous channels were prepared using an O/W microemulsion system, consisting of CTAB (or PVP), ethanol, cyclohexane and water as template.

Preparation and Pharmacokinetics of Candesartan Cilexetil with Polymer Materials in Self-Microemulsifying Drug Delivery Systems

2013 ◽  
Vol 661 ◽  
pp. 104-107
Author(s):  
Rong Rong Li ◽  
Zhi Fei Xie ◽  
Ming Xing Liu ◽  
Hong Da Zhu
Keyword(s):  
Drug Delivery ◽  
Size Distribution ◽  
Drug Delivery Systems ◽  
Candesartan Cilexetil ◽  
Delivery Systems ◽  
Polydispersity Index ◽  
Polymer Materials ◽  
Narrow Size Distribution ◽  
Good Agreement

The candesartan cilexetil SMEDDS with PEG-PLA as long-circulating materials were successfully prepared and characterized by appearance, size and size distribution, morphology of emulsion and stability. The emulsion showed a narrow size distribution, well-proportioned in good agreement with polydispersity index of 0.005 and 3.6 nm diameter. The candesartan cilexetil SMEDDS were precipitated for 30 days at 25 °C or 37 °C. Meanwhile, Pharmacokinetics experiments illuminated that the candesartan cilexetil SMEDDS in rats had a larger drug curve concentration (AUC) compared to the tablets in the experiments.

scholarly journals A theranostic nanocomposite system based on radial mesoporous silica hybridized with Fe3O4 nanoparticles for targeted magnetic field responsive chemotherapy of breast cancer

RSC Advances ◽  
2018 ◽  
Vol 8 (8) ◽  
pp. 4321-4328 ◽  
Author(s):  
Qin Gao ◽  
Wensheng Xie ◽  
Yu Wang ◽  
Dan Wang ◽  
Zhenhu Guo ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Magnetic Field ◽  
Drug Delivery ◽  
Mesoporous Silica ◽  
Drug Delivery System ◽  
Delivery System ◽  
Fe3o4 Nanoparticles ◽  
Nanocomposite System

Herein, we report a smart theranostic drug delivery system based on radial mesoporous silica, containing uIO for T2-weighted MRI and lIO for AMF-responsive chemotherapy.

Ultrasmall polymersomes of poly-α,β-(N-2-hydroxyethyl l-aspartamide)-graft-poly(l-lactic acid) copolymers as a potential drug carrier

RSC Advances ◽  
2016 ◽  
Vol 6 (89) ◽  
pp. 86361-86372 ◽  
Author(s):  
Hyun Jin Lee ◽  
Seung-Hae Kwon ◽  
Kwang-Suk Jang
Keyword(s):  
Drug Delivery ◽  
Lactic Acid ◽  
Size Distribution ◽  
Thermodynamic Stability ◽  
Drug Carrier ◽  
Potential Drug ◽  
Narrow Size Distribution ◽  
High Thermodynamic Stability ◽  
Delivery Platform

Ultrasmall polymersomes are suggested as a drug delivery platform based on their suitable size, narrow size distribution, uniform morphology, and high thermodynamic stability.

Preparation of Mesoporous Silica Nanoparticles for Insulin Drug Delivery

2013 ◽  
Vol 829 ◽  
pp. 251-257 ◽  
Author(s):  
Abdollah Zakeri Siavashani ◽  
Masoume Haghbin Nazarpak ◽  
Fateme Fayyaz Bakhsh ◽  
Tayebeh Toliyat ◽  
Mehran Solati-Hashjin
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Size Distribution ◽  
Mesoporous Silica Nanoparticles ◽  
Drug Carrier ◽  
Drug Loading ◽  
Hydrothermal Process ◽  
Analytical Techniques

This study has focused on mesoporous silica nanoparticles as a drug delivery system of insulin, which was synthesized via a hydrothermal process. The morphology and composition of the silica nanoparticles were characterized by different analytical techniques such as Scanning Electron Microscope (SEM), X-Ray Diffraction Analysis (XRD), Fourier Transform Infrared spectroscopy (FTIR) and BrunauerEmmettTeller (BET). The percentage of drug loading and the in vitro drug release properties of the mesoporous silica nanoparticles in gastrointestinal tract were investigated in simulated gastrointestinal conditions by ultraviolet-visible spectroscopy. The results showed the amorphous structure of SBA-15 in mesoporous silica particles has a narrow pore size distribution. Also, particles shape was nearly wheat-like with almost homogeneous size distribution. Furthermore, it was revealed that the mesoporous silica nanoparticles have a high insulin loading and release capacity. These prominent behaviors make mesoporous silica nanoparticles promising material as a drug carrier for insulin delivery.

Macrostructure and microphysics of Saturn's E-ring

1984 ◽  
Vol 75 ◽  
pp. 607-613 ◽  
Author(s):  
Kevin D. Pang ◽  
Charles C. Voge ◽  
Jack W. Rhoads
Keyword(s):  
Size Distribution ◽  
Spherical Shape ◽  
Mie Scattering ◽  
Narrow Size Distribution ◽  
Electrostatic Levitation ◽  
Volcanic Origin ◽  
Micron Diameter

Abstract.All observed optical and infrared properties of Saturn's E-ring can be explained in terms of Mie scattering by a narrow size distribution of ice spheres of 2 - 2.5 micron diameter. The spherical shape of the ring particles and their narrow size distribution imply a molten (possibly volcanic) origin on Enceladus. The E-ring consists of many layers, possibly stratified by electrostatic levitation.

Recent Advances of Mesoporous Silica Based Multifunctional Nano Drug Delivery Systems

2013 ◽  
Vol 40 (10) ◽  
pp. 1014
Author(s):  
Xiao-Hong HAO ◽  
Cui-Miao ZHANG ◽  
Xiao-Long LIU ◽  
Xing-Jie LIANG ◽  
Guang JIA ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Recent Advances ◽  
Nano Drug Delivery

Recent Advances in Application of Azobenzenes Grafted on Mesoporous Silica Nanoparticles in Controlled Drug Delivery Systems Using Light as External Stimulus

2020 ◽  
Vol 20 (11) ◽  
pp. 1001-1016
Author(s):  
Sandra Ramírez-Rave ◽  
María Josefa Bernad-Bernad ◽  
Jesús Gracia-Mora ◽  
Anatoly K. Yatsimirsky
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Drug Delivery Systems ◽  
Mesoporous Silica Nanoparticles ◽  
High Surface ◽  
Delivery Systems ◽  
Surface Reactivity ◽  
External Stimulus ◽  
Recent Advances

Hybrid materials based on Mesoporous Silica Nanoparticles (MSN) have attracted plentiful attention due to the versatility of their chemistry, and the field of Drug Delivery Systems (DDS) is not an exception. MSN present desirable biocompatibility, high surface area values, and a well-studied surface reactivity for tailoring a vast diversity of chemical moieties. Particularly important for DDS applications is the use of external stimuli for drug release. In this context, light is an exceptional alternative due to its high degree of spatiotemporal precision and non-invasive character, and a large number of promising DDS based on photoswitchable properties of azobenzenes have been recently reported. This review covers the recent advances in design of DDS using light as an external stimulus mostly based on literature published within last years with an emphasis on usually overlooked underlying chemistry, photophysical properties, and supramolecular complexation of azobenzenes.

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