Preparation and Pharmacokinetics of Candesartan Cilexetil with Polymer Materials in Self-Microemulsifying Drug Delivery Systems

2013 ◽  
Vol 661 ◽  
pp. 104-107
Author(s):  
Rong Rong Li ◽  
Zhi Fei Xie ◽  
Ming Xing Liu ◽  
Hong Da Zhu
Keyword(s):  
Drug Delivery ◽  
Size Distribution ◽  
Drug Delivery Systems ◽  
Candesartan Cilexetil ◽  
Delivery Systems ◽  
Polydispersity Index ◽  
Polymer Materials ◽  
Narrow Size Distribution ◽  
Good Agreement

The candesartan cilexetil SMEDDS with PEG-PLA as long-circulating materials were successfully prepared and characterized by appearance, size and size distribution, morphology of emulsion and stability. The emulsion showed a narrow size distribution, well-proportioned in good agreement with polydispersity index of 0.005 and 3.6 nm diameter. The candesartan cilexetil SMEDDS were precipitated for 30 days at 25 °C or 37 °C. Meanwhile, Pharmacokinetics experiments illuminated that the candesartan cilexetil SMEDDS in rats had a larger drug curve concentration (AUC) compared to the tablets in the experiments.

Microfluidic-mediated nano-drug delivery systems: from fundamentals to fabrication for advanced therapeutic applications

Nanoscale ◽  
2020 ◽  
Vol 12 (29) ◽  
pp. 15512-15527 ◽  
Author(s):  
Qingming Ma ◽  
Jie Cao ◽  
Yang Gao ◽  
Shangcong Han ◽  
Yan Liang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Size Distribution ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Therapeutic Applications ◽  
Nano Drug Delivery

Microfluidics-mediated NDDS show uniform morphology, size and size distribution, reduced batch-to-batch variations and controllable drug delivering capacity.

scholarly journals Nanotechnology and Microtechnology in Drug Delivery Systems

Dose-Response ◽  
2020 ◽  
Vol 18 (2) ◽  
pp. 155932582090781 ◽  
Author(s):  
Jingyao Sun ◽  
Zhaogang Yang ◽  
Lesheng Teng
Keyword(s):  
Drug Delivery ◽  
Time Distribution ◽  
Drug Delivery Systems ◽  
Therapeutic Index ◽  
Controlled Drug Release ◽  
Drug Carriers ◽  
Delivery Systems ◽  
Polymer Materials ◽  
Special Issue ◽  
Targeting Delivery

A special issue of the journal Dose-Response entitled “Nanotechnology and Microtechnology in Drug Delivery Systems” is proposed. In pharmaceutical studies, new and existing drugs continue to be investigated for their poor specificity, solubility, therapeutic index, and immunogenicity. In order to solve these problems, drug delivery systems are essential for controlled drug release. It has been shown that the size and shape (nano- or micro-) of drug carriers can affect a drug’s circulation time, distribution, and cellular uptake. Hence, it is not surprising that nanotechnology and microtechnology have been explored as powerful tools for drug delivery in past decades. The main topics will be related to the technologies including microtechnology for the sustained release of drug, nanotechnology for the targeting delivery of drugs, new polymer materials nanotechnology, nanotechnology in drugs combination application, and so on.

Systematic development of novel cationic self-nanoemulsifying drug delivery systems of candesartan cilexetil with enhanced biopharmaceutical performance

RSC Advances ◽  
2015 ◽  
Vol 5 (87) ◽  
pp. 71500-71513 ◽  
Author(s):  
Gajanand Sharma ◽  
Sarwar Beg ◽  
Kaushik Thanki ◽  
O. P. Katare ◽  
Sanyog Jain ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Oral Bioavailability ◽  
Drug Delivery Systems ◽  
Candesartan Cilexetil ◽  
Delivery Systems ◽  
Systematic Development

The current studies entail systematic development, optimization and evaluation of cationic self-nanoemulsifying drug delivery systems (C-SNEDDS) for enhancing the oral bioavailability of candesartan cilexetil.

scholarly journals The Structural Characteristics of Seaweed Polysaccharides and Their Application in Gel Drug Delivery Systems

Marine Drugs ◽  
2020 ◽  
Vol 18 (12) ◽  
pp. 658
Author(s):  
Haowei Zhong ◽  
Xiaoran Gao ◽  
Cui Cheng ◽  
Chun Liu ◽  
Qiaowen Wang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Recent Literature ◽  
Alginic Acid ◽  
Biological Activities ◽  
Structural Characteristics ◽  
Delivery Systems ◽  
Polymer Materials ◽  
Component Mixture ◽  
Anticancer Drug Delivery

In recent years, researchers across various fields have shown a keen interest in the exploitation of biocompatible natural polymer materials, especially the development and application of seaweed polysaccharides. Seaweed polysaccharides are a multi-component mixture composed of one or more monosaccharides, which have the functions of being anti-virus, anti-tumor, anti-mutation, anti-radiation and enhancing immunity. These biological activities allow them to be applied in various controllable and sustained anti-inflammatory and anticancer drug delivery systems, such as seaweed polysaccharide-based nanoparticles, microspheres and gels, etc. This review summarizes the advantages of alginic acid, carrageenan and other seaweed polysaccharides, and focuses on their application in gel drug delivery systems (such as nanogels, microgels and hydrogels). In addition, recent literature reports and applications of seaweed polysaccharides are also discussed.

Recent research progress on polyphosphazene-based drug delivery systems

2020 ◽  
Vol 8 (8) ◽  
pp. 1555-1575 ◽  
Author(s):  
Zhipeng Ni ◽  
Haojie Yu ◽  
Li Wang ◽  
Di Shen ◽  
Tarig Elshaarani ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Synthetic Polymer ◽  
Polymer Materials ◽  
Research Progress ◽  
Structural Flexibility ◽  
Degradation Properties ◽  
Controllable Degradation ◽  
Recent Research Progress

In recent years, synthetic polymer materials have become a research hotspot in the field of drug delivery. Polyphosphazenes are one of the most promising biomedical materials for the future due to their controllable degradation properties and structural flexibility.

Synthesis and Selfassambling of Amphiphilic Oligoesters Based on Pyromellitic Acid

2016 ◽  
Vol 10 (2) ◽  
pp. 159-172 ◽  
Author(s):  
Ihor Tarnavchyk ◽  
◽  
Andriy Voronov ◽  
Volodymyr Donchak ◽  
Olga Budishevska ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Polyethylene Glycol ◽  
Size Distribution ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Fatty Alcohols ◽  
Polyethylene Glycols ◽  
Pyromellitic Acid ◽  
New Class ◽  
Solubilization Capacity

The method for synthesis of a new class of amphiphilic oligoesters of pyromellitic acid is developed. As hydrophilic fragments polyethylene glycols or polyethylene glycol mono methyl ethers were used, as lipophilic ones – primary fatty alcohols or cholesterol. The structure of the synthesized oligoesters was confirmed by IR- and PMR-spectroscopy. The oligoesters could solubilize water-insoluble substances, for example such effective antitumor lipophilic drug as curcumin. The high solubilization capacity of the OEPA assemblies and their biodegradability, as well as other properties (size distribution, ζ-potential) make the oligoesters considered as promising materials for the design of drug delivery systems.

Techniques For The Preparation of Tissue Samples Containing Injectable Polymer Microcapsules

1985 ◽  
Vol 43 ◽  
pp. 710-711
Author(s):  
G.E. Visscher ◽  
R. L. Robison ◽  
G. J. Argentieri
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Gastrocnemius Muscle ◽  
Degradation Process ◽  
Delivery Systems ◽  
Tissue Reaction ◽  
Electron Microscopic ◽  
Tissue Samples ◽  
Injectable Polymer ◽  
Microscopic Techniques

The use of various bioerodable polymers as drug delivery systems has gained considerable interest in recent years. Among some of the shapes used as delivery systems are films, rods and microcapsules. The work presented here will deal with the techniques we have utilized for the analysis of the tissue reaction to and actual biodegradation of injectable microcapsules. This work has utilized light microscopic (LM), transmission (TEM) and scanning (SEM) electron microscopic techniques. The design of our studies has utilized methodology that would; 1. best characterize the actual degradation process without artifacts introduced by fixation procedures and 2. allow for reproducible results.In our studies, the gastrocnemius muscle of the rat was chosen as the injection site. Prior to the injection of microcapsules the skin above the sites was shaved and tattooed for later recognition and recovery. 1.0 cc syringes were loaded with the desired quantity of microcapsules and the vehicle (0.5% hydroxypropylmethycellulose) drawn up. The syringes were agitated to suspend the microcapsules in the injection vehicle.

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