Transverse permeability measurements of gas shales under replicated in-situ flow conditions: Mathematical modeling and laboratory testing

2021 ◽  
pp. 104159
Author(s):  
Ruimin Feng ◽  
Jun Liu ◽  
Michelle Bernhardt-Barry ◽  
Shengnan Chen
Keyword(s):  
Mathematical Modeling ◽  
Laboratory Testing ◽  
Flow Conditions ◽  
Transverse Permeability ◽  
Gas Shales

scholarly journals Cutting Resistance Laboratory Testing Methodology for Underwater Coal Mining

Minerals ◽  
2021 ◽  
Vol 11 (6) ◽  
pp. 564
Author(s):  
Vladimir Čebašek ◽  
Veljko Rupar ◽  
Stevan Đenadić ◽  
Filip Miletić
Keyword(s):  
Coal Mining ◽  
Laboratory Testing ◽  
Water Pressure ◽  
Laboratory Data ◽  
Working Environment ◽  
Laboratory Research ◽  
Surrounding Water ◽  
Cutting Resistance ◽  
Testing Methodology

The bucket-wheel dredge “Kovin I” for underwater coal mining with bucket-wheel type UCW-450 has been in operation for over 20 years. Based on analyzing the bucket-wheel dredger performance, productivity, maintenance costs, and reliability, a rational decision was made: to rehabilitate the most essential parts of the dredge, including the bucket wheel and the gearbox. However, the selection and construction of the excavator parts were performed on the ground of available laboratory data for digging resistance. The data itself was determined by the testing methodology that did not include the influence of surrounding water pressure at a certain depth of mining. According to the previous findings, it was necessary to develop a specific research and testing program that would involve appropriate laboratory testing of the geomechanical parameters. These were to represent the influence of hydrostatic water pressure on the working environment—coal. Nevertheless, geomechanical laboratory research tests were initially modified to provide reliable data of cutting resistance, especially in the water under different hydrostatic pressures, fully simulating the “in situ” working conditions of mining, i.e., cutting.

Adherence of platelets to in situ albumin-binding surfaces under flow conditions: role of surface-adsorbed albumin

2012 ◽  
Vol 7 (4) ◽  
pp. 045007 ◽  
Author(s):  
Sanjukta Guha Thakurta ◽  
Robert Miller ◽  
Anuradha Subramanian
Keyword(s):  
Albumin Binding ◽  
Flow Conditions

Laboratory Testing for HER2/neu in Breast Carcinoma: An Evolving Strategy to Predict Response to Targeted Therapy

2001 ◽  
Vol 8 (5) ◽  
pp. 415-418 ◽  
Author(s):  
Nils M. Diaz
Keyword(s):  
Targeted Therapy ◽  
Breast Carcinoma ◽  
Gene Amplification ◽  
Laboratory Testing ◽  
False Positives ◽  
Response To Therapy ◽  
Fish Analysis ◽  
Breast Carcinomas ◽  
Testing Strategies

Background Laboratory testing of HER2/neu in breast carcinoma has become vital to patient care following the approval of trastuzumab as the first therapy to target the HER2/neu oncoprotein. Initial clinical trials used immunohistochemistry (IHC) to test for HER2/neu overexpression in order to select patients for therapy. Fluorescence in situ hybridization (FISH), which tests for gene amplification, is more specific and sensitive than IHC when either assay is compared with HER2/neu overexpression as determined by Northern or Western blot analysis. Many weak overexpressors on IHC testing are not gene amplified on FISH analysis. Such weak overexpressors may be considered false-positives and raise the question of how best to test for HER2/neu. Methods The literature was surveyed regarding testing for HER2/neu overexpression in breast carcinomas and alternative testing strategies. Results False-positive results are a significant problem when IHC is exclusively used to test for HER2/neu overexpression. The false-positives are overwhelmingly confined to the group of 2+ positives and do not respond to targeted therapy. In contrast, concordance between IHC and FISH is high when immunostaining is interpreted as either negative or strongly positive (3+). Whereas some recent studies have suggested that FISH may better predict response to anti-HER2/neu therapy than IHC, others have indicated that IHC is as effective a predictor as FISH. IHC is less technically demanding and costly than FISH. Conclusions IHC analysis of HER2/neu in breast carcinoma is a useful predictor of response to therapy with trastuzumab when strongly positive. Negative immunostaining is highly concordant with a lack of gene amplification by FISH. Most weakly positive overexpressors are false-positives on testing with FISH. Thus, screening of breast carcinomas with IHC and confirmation of weakly positive IHC results by FISH is an effective evolving strategy for testing HER2/neu as a predictor of response to targeted therapy.

Mathematical Modeling of In Situ Vapor Stripping of Contaminated Soils

1990 ◽  
Vol 30 (3) ◽  
pp. 281-293
Author(s):  
David J. Wilson ◽  
Ann N. Clarke ◽  
Robert D. Mutch
Keyword(s):  
Mathematical Modeling ◽  
Contaminated Soils ◽  
Vapor Stripping

Intracellular diffusion gradients of O2 and ATP

1986 ◽  
Vol 250 (5) ◽  
pp. C663-C675 ◽  
Author(s):  
D. P. Jones
Keyword(s):  
Mathematical Modeling ◽  
High Flux ◽  
Concentration Gradients ◽  
Electron Microscopic ◽  
Intracellular Diffusion ◽  
Metabolite Concentrations ◽  
Major Factors ◽  
Atp Supply ◽  
Endogenous Enzymes

Endogenous enzymes with different subcellular localizations provide in situ probes to study O2 and ATP concentration at various sites within cells. Results from this approach indicate that substantial intracellular concentration gradients occur under some O2- and ATP-limited conditions. These studies, along with electron microscopic analyses and mathematical modeling, indicate that clustering and distribution of mitochondria are major factors in determining the magnitude and location of the concentration gradients. The mitochondria appear to be clustered in sites of high ATP demand to maximize ATP supply under conditions of limited production. The size of such clusters is limited by the magnitude of the O2 gradient needed to provide adequate O2 concentrations for mitochondrial function within the clusters. Thus microheterogeneity of metabolite concentrations can occur in cells without membranal compartmentation and may be important in determining the rates of various high-flux processes.

Influence of High Duty Ratio and Frequency in WECM Employing In Situ Fabricated Wire Electrode

2017 ◽  
Vol 5 (4) ◽  
Author(s):  
S. Debnath ◽  
J. Kundu ◽  
B. Bhattacharyya
Keyword(s):  
Mathematical Modeling ◽  
Electrochemical Machining ◽  
Burr Formation ◽  
Duty Ratio ◽  
Minimum Width ◽  
Applied Frequency ◽  
Early Adoption ◽  
Novel Approach ◽  
Microfabrication Techniques

To adapt with today's rapidly changing world, fabrication of intricate microparts is becoming an urgent need. Manufacturing of these microparts with stringent requirements necessitates the early adoption of different microfabrication techniques. Wire electrochemical machining (WECM) is such a process which removes excess metal by dissolving it electrochemically. This process can easily generate features downscaled to micron ranges and offers several advantages like the requirement of very simple setup, fabrication of accurate complex microfeatures without undergoing any thermal stress, burr formation, and tool wear, which make it superior from other existing micromachining processes. However, this process is new, and little is known about its applicability and feasibility. Hence, the present work is directed towards developing suitable WECM setup to fabricate microfeatures by introducing proper means for enhancing the mass transport phenomenon. The tungsten tool wire for machining has been in situ etched to a diameter of 23.43 μm by a novel approach for retaining its regular cylindrical form and has been implemented during machining. Moreover, the influences of high duty ratio and applied frequency have been investigated on the corresponding width of the fabricated microslits and the experimental results have been represented graphically where the minimum width of the microslit is obtained as 44.85 μm. Furthermore, mathematical modeling has been developed to correlate duty ratio and applied frequency with generated slit width. Additionally, the mathematical modeling has been validated with practical results and complex stepped type microfeatures have been generated to establish process suitability.

Piezoelectric energy harvesting from roadway deformation under various traffic flow conditions

2020 ◽  
Vol 31 (15) ◽  
pp. 1751-1762
Author(s):  
Yangyang Zhang ◽  
He Zhang ◽  
Chaofeng Lü ◽  
Yisheng Chen ◽  
Ji Wang
Keyword(s):  
Energy Harvesting ◽  
Traffic Flow ◽  
Laboratory Tests ◽  
Piezoelectric Energy Harvesting ◽  
Flow Conditions ◽  
Energy Harvesters ◽  
Piezoelectric Energy ◽  
Roadway Deformation ◽  
Real Traffic

Many laboratory tests and in situ measurements have been conducted to study piezoelectric energy harvesting from roadway deformation. However, the performance of piezoelectric energy harvesters under real traffic flow conditions is still unknown. In this study, an electromechanical model of piezoelectric energy harvesters with detailed parameters (including the geometric parameters, material parameters, and circuits) is established, and the influences of traffic flow conditions (i.e. traffic speed and traffic density) on the output power of piezoelectric energy harvesters are analyzed by employing a scaling law method and traffic flow theory. The results indicate that remarkable differences exist in the load patterns and the frequencies between the laboratory tests (or in situ measurements) and real traffic flow conditions. Because of these differences, the results (especially the output electric power and optimization design methods) of previous studies may be inapplicable for piezoelectric energy harvesters embedded in roadways. Considering the distinguishing features of the traffic load pattern, the optimization criteria to determine the geometric parameters and the intrinsic system parameter of piezoelectric energy harvesters are obtained, and the corresponding optimal output power densities of the piezoelectric energy harvesters are also quantitatively calibrated. These theoretical results may serve as guidelines for optimizing the design of piezoelectric energy harvesters embedded in roadways under different traffic flow conditions.

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