Self-assembly of silica spheres on silk fibroin spheres for synthesis of porous hollow silica spheres and their in vitro biocompatibility and drug delivery property

2019 ◽  
Vol 522 ◽  
pp. 119557 ◽  
Author(s):  
Lulu Shen ◽  
Li Guo ◽  
Song Chen ◽  
Aili Wei ◽  
Akiyoshi Osaka ◽  
...  
Langmuir ◽  
2009 ◽  
Vol 25 (20) ◽  
pp. 12367-12373 ◽  
Author(s):  
Binyang Du ◽  
Zheng Cao ◽  
Zhenbing Li ◽  
Aixiong Mei ◽  
Xinghong Zhang ◽  
...  

Author(s):  
Manohar D Mullassery ◽  
Noeline B Fernandez ◽  
Surya R ◽  
Diana Thomas

Objective: The scope of the present study was the preparation and characterization of a novel composite acrylamide β-cyclodextrin grafted 3-aminopropyltriethoxysilane bentonite (AMCD-g-APSB), for the controlled delivery of curcumin (CUR).Methods: AMCD-g-APSB, was synthesized by solvent-free conditions using microwave irradiation. The structure and surface morphology of the composite was established using Fourier transform infrared spectroscopy, X-ray diffraction, scanning electron microscopy, thermal analysis, etc.Results: The swelling percentage of the composite depends on both time and pH of the medium. The maximum swelling of the composite occurred at a pH of 7.4. The maximum drug encapsulation was occurring at a pH 3. About 96.5% of drug was loaded at pH 3. In vitro biocompatibility study was performed, and the result showed good biocompatibility of the composite in the concentration range 2.5–50 μg/ml.Conclusions: Drug delivery study of the composite proved that CUR could be successfully released in a controlled manner in the colon without much loses of the drug in the stomach.


2019 ◽  
Vol 7 (4) ◽  
pp. 1574-1584 ◽  
Author(s):  
Junmei Fan ◽  
Si Hui ◽  
Trevor P. Bailey ◽  
Alexander Page ◽  
Ctirad Uher ◽  
...  

Graphene aerogels grown on hollow silica spheres through spark plasma sintering lead to ultralow thermal conductivity and high compressive strength.


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