The use of combined therapy with CFPE and IVIG in a patient with refractory standard therapy for stiff person syndrome

Aim. To evaluate the dynamics of cytokine status (IL-1ß, IL-4, IL-6, IL-10) and hormonal profile (cortisol, ACTH, β-endorphins) in patients with stable angina II-III functional class in the course of standard treatment and combined use of TES-therapy.Materials and methods. All patients were divided into 2 groups: 1st (n=30) therapy of angina according to the Protocol and 2nd (n=30) combined therapy of angina according to the Protocol and TES-therapy.Results. The results showed that normalization of the studied cytokines level in patients of the 1st group is not improved.In the 2nd group of patients statistically the levels of the studied cytokines was significantly decreasing (p≤0.01) and the levels of ACTH, cortisol and β-endorphin were significantly (p≤0.01) increasing.Conclusion. The obtained results suggest that TES-therapy conducted in the 2nd group of patients, contributes to the correction of cytokine imbalance and hormonal profile, which indicates the necessity of its inclusion in standard therapy of angina.

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Efficacy of Olanzapine Combined Therapy for Patients Receiving Highly Emetogenic Chemotherapy Resistant to Standard Antiemetic Therapy

BioMed Research International ◽

10.1155/2015/956785 ◽

2015 ◽

Vol 2015 ◽

pp. 1-6 ◽

Cited By ~ 6

Author(s):

Masakazu Abe ◽

Yuka Kasamatsu ◽

Nobuhiro Kado ◽

Shiho Kuji ◽

Aki Tanaka ◽

...

Keyword(s):

Standard Therapy ◽

Combined Therapy ◽

Gynecologic Cancer ◽

Emetogenic Chemotherapy ◽

Antiemetic Therapy ◽

Preventive Effect ◽

Highly Emetogenic Chemotherapy ◽

Oral Olanzapine ◽

Phase 0 ◽

Delayed Phase

Objective. Olanzapine is proved to be effective for chemotherapy induced nausea and vomiting (CINV). But its efficacy in combination with standard antiemetic therapy is unknown. The purpose of this study is to prove the preventive effect of olanzapine for the prevention of CINV caused by highly emetogenic chemotherapy when used with standard antiemetic therapy.Method. Gynecologic cancer patients receiving cisplatin-based chemotherapy who had grade 2 or 3 nausea in overall phase (0–120 h after chemotherapy) despite standard therapy were assigned to this study. From the next cycles to cycles in which patients developed grade 2 or 3 nausea, they received olanzapine with standard therapy. 5 mg oral olanzapine was administered for 7 days from the day before chemotherapy. The effectiveness of preventive administration of olanzapine was evaluated retrospectively. The primary endpoint was nausea control rate (grade 0 or 1) with olanzapine.Results. Fifty patients were evaluable. The nausea control rate with olanzapine was improved from 58% to 98% in acute phase (0–24 h after chemotherapy) and 2% to 94% in delayed phase (24–120 h after chemotherapy). In overall phase, the nausea control rate improved from 0% to 92%, and it was statistically significant (P<0.001).Conclusion. Preventive use of olanzapine combined with standard antiemetic therapy showed improvement in control of refractory nausea.

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Efficacy of ambroxol (Lasolvan) in patients with chronic obstructive pulmonary disease

Russian Pulmonology ◽

10.18093/0869-0189-2009-0-1-73-77 ◽

2009 ◽

pp. 73-76

Author(s):

U. R. Farkhutdinov ◽

V. V. Petryakov ◽

Sh. U. Farkhutdinov

Keyword(s):

Chronic Obstructive Pulmonary Disease ◽

Pulmonary Disease ◽

Standard Therapy ◽

Clinical Symptoms ◽

Combined Therapy ◽

Combined Treatment ◽

Chronic Obstructive ◽

Local Immunity ◽

Obstructive Pulmonary Disease ◽

Comparator Group

The aim of this study was to evaluate efficacy of mucolytic drug ambroxol (Lasolvan) as a part of combined treatment of patients with chronic obstructive pulmonary disease (COPD). Fifty-two patients with exacerbation of COPD participated in the study. Bronchoalveolar lavage fluid (BALF) obtained during bronchofiberoscopy was examined for cell differential and immunoglobulin concentration. The latter was found to be reduced. The patients were divided into 2 groups: the main group included 25 patients treated with standard therapy (antibiotics, bronchodilators, glucocorticosteroids) and inhaled ambroxol through a nebulizer; the comparator group included 27 patients with COPD who received standard therapy and placebo (inhaled saline solution). Administration of ambroxol has led to improvement in clinical symptoms and local immunity. In the comparator group, the duration of exacerbation was longer and improvement in the local immunity was insignificant. Therefore, the use of ambroxol as a part of combined therapy of COPD exacerbation could improve the local immunity and contribute to the result of treatment.

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FIBROBLAST GROWTH FACTOR (FGF) 21 AT MULTIMORBID CARDIOVASCULAR PATHOLOGY WITH ANXIETY AND DEPRESSIVE DISORDERS IN YOUNG AND MIDDLE-AGED MEN

HERALD of North-Western State Medical University named after I I Mechnikov ◽

10.17816/mechnikov201572108-113 ◽

2015 ◽

Vol 7 (2) ◽

pp. 108-113

Author(s):

A S Partsernyak ◽

G A Proshyai ◽

S A Partsernyak ◽

M A Aflitonov ◽

A N Mironenko ◽

...

Keyword(s):

Standard Therapy ◽

Depressive Disorders ◽

Combined Therapy ◽

Severe Depression ◽

Fold Increase ◽

Simple Random Sampling ◽

Correction Method ◽

Test Methods ◽

Mild Depression ◽

Cardiovascular Pathology

Evaluate (FGF) 21 at multimorbid cardiovascular pathology (MCVP) (coronary artery disease (CAd), hypertension, metabolic syndrome (MS)) with non-psychotic mental disorders (NPMd) anxiety/ depressive type. Identify the effectiveness of visual-auditory effects in the treatment of these pathologies. design and methods: The study included 70 men (mean age 37,46±6,74) with MCVP divided into 4 groups by simple random sampling, and 20 healthy men (mean age 38,3±6,73 g). Patients in Group 1 (n = 22) received standard therapy CAd, hypertension and NPMd, in group 2 (n = 25) standard therapy CAd, hypertension, NPMd and visual-auditory correction. Patients of group 3 (n =23) received standard therapy CAd, hypertension, NPMd, visual-auditory correction and psychotherapy. used in the study: complex psychological test methods and laboratory-instrumental evaluation of the cardiovascular system. definition of FGF21 performed by ELISA using kits BCM diagnostics SK00145-01 (BCM diagnostics, uSA). Results: Identified a two-fold increase in the concentration of serum FGF 21 after the course of standard therapy in the first group. In the other groups showed a statistically significant decrease FGF21 after psychopharmacological and visual-auditory therapy. In all groups after treatment was observed significantly change the type of NdP «severe depression»,«clinical anxiety» to «mild depression»; «subclinical anxiety» (p <0,001). Conclusions: FGF21 may be important biomarker for early diagnosis of metabolic abnormalities in this pathology. Results indicate benefits of combined therapy MCVP with the use of psychotropic drugs and visual-auditory correction method. Choose the method of complex treatment given the side effects of pharmacological agents.

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Evaluation of effectiveness of thioctic acid use in combined therapy of angiodistonia and polyneuropathy syndrome

Perm Medical Journal ◽

10.17816/pmj37417-25 ◽

2020 ◽

Vol 37 (4) ◽

pp. 17-25

Author(s):

Natal'ja N. Malyutina ◽

Arina F. Bolotova ◽

Roman B. Eremeev ◽

Dmitriy Yu. Sosnin

Keyword(s):

Standard Therapy ◽

Comparison Group ◽

Combined Therapy ◽

Randomized Study ◽

Pain Syndrome ◽

Main Group ◽

Thioctic Acid ◽

Results Of Treatment ◽

Significant Difference ◽

Additional Therapy

Objective. The aim of the study was to investigate the effectiveness of the preparation of thioctic acid combined with standard therapy among patients with angiodistonic syndrome and vegetative-sensory polyneuropathy of the extremities due to the influence of general vibration. Materials and methods. A prospective randomized study of two groups of patients with vibration disease was conducted: the main group (n = 30) and the comparison group (n = 30). All patients received standard therapy, while the main group received additional therapy with octolipen (300 mg per os 2 times a day). Results. The results of questionnaires and objective examination of patients did not establish the occurrence of any side effects when including the drug in the therapy. The survey data proved statistically significant differences in the assessment of pain syndrome at rest and in the occurrence of night pains (p = 0.022). At the same time, when assessing the severity of paresthesia, no statistically significant difference was found between the groups (p = 0.5536). The therapy was accompanied by normalization of the antioxidant status (AOS) in both groups: in the main group, the median AOS increased by 1.342 times and in the comparison group by 1.267 times. In the statistical evaluation, the inclusion of thioctic acid in the treatment was accompanied by a statistically significant increase in the AOS not only with the initial data (p 0.00001), but also in comparison with the results of treatment of patients in the comparison group (p = 0.0387). The data from the reovasographic study also showed that the therapy was more effective with additional inclusion of thioctic acid drug to it. Conclusions. Thus, the data obtained justify the feasibility and effectiveness of using thioctic acid preparation in the treatment of angiodistonia and polyneuropathy syndromes.

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