Maternal folic acid supplementation modulates DNA methylation and gene expression in the rat offspring in a gestation period-dependent and organ-specific manner

2016 ◽  
Vol 33 ◽  
pp. 103-110 ◽  
Author(s):  
Anna Ly ◽  
Lisa Ishiguro ◽  
Denise Kim ◽  
David Im ◽  
Sung-Eun Kim ◽  
...  
Keyword(s):  
Gene Expression ◽  
Dna Methylation ◽  
Folic Acid ◽  
Folic Acid Supplementation ◽  
Gestation Period ◽  
Acid Supplementation ◽  
Rat Offspring ◽  
Specific Manner ◽  
Organ Specific

scholarly journals Maternal and postweaning folic acid supplementation interact to influence body weight, insulin resistance, and food intake regulatory gene expression in rat offspring in a sex-specific manner

2016 ◽  
Vol 41 (4) ◽  
pp. 411-420 ◽  
Author(s):  
Pedro S.P. Huot ◽  
Anna Ly ◽  
Ignatius M.Y. Szeto ◽  
Sandra A. Reza-López ◽  
Daniel Cho ◽  
...  
Keyword(s):  
Gene Expression ◽  
Insulin Resistance ◽  
Body Weight ◽  
Folic Acid ◽  
Acid Content ◽  
Maternal Diet ◽  
Folic Acid Supplementation ◽  
Acid Supplementation ◽  
Rat Offspring ◽  
Specific Manner

Maternal intake of multivitamins or folic acid above the basal dietary requirement alters the growth and metabolic trajectory of rat offspring. We hypothesized that a modest increase in the folic acid content of maternal diets would alter the offspring’s metabolic phenotype, and that these effects could be corrected by matching the folic acid content of the offspring’s diet with that of the maternal diet. Female Sprague–Dawley rats were placed on a control or a 2.5× folic acid-supplemented diet prior to mating and during pregnancy and lactation. At weaning, pups from each maternal diet group were randomized to the control or to the 2.5× folic acid-supplemented diet for 25 weeks. Male pups from dams fed the folic acid-supplemented diet were 3.7% heavier than those from control-fed dams and had lower mRNA expression for leptin receptor Obrb isoform (Lepr) (11%) and Agouti-related protein (Agrp) (14%). In contrast, female pups from folic acid-supplemented dams were 5% lighter than those from control-fed dams and had lower proopiomelanocortin (Pomc) (42%), Lepr (32%), and Agrp (13%), but higher neuropeptide Y (Npy) (18%) mRNA expression. Folic acid supplementation ameliorated the alterations induced by maternal folic acid supplementation in male pups and led to the lowest insulin resistance, but the effects were smaller in female pups and led to the highest insulin resistance. In conclusion, maternal folic acid supplementation at 2.5× the control level was associated with alterations in body weight and hypothalamic gene expression in rat offspring in a sex-specific manner, and some of these effects were attenuated by postweaning folic acid supplementation.

Effect of maternal and postweaning folic acid supplementation on global and gene-specific DNA methylation in the liver of the rat offspring

2013 ◽  
Vol 57 (4) ◽  
pp. 677-685 ◽  
Author(s):  
Karen K. Y. Sie ◽  
Jennifer Li ◽  
Anna Ly ◽  
Kyoung-Jin Sohn ◽  
Ruth Croxford ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Folic Acid ◽  
Folic Acid Supplementation ◽  
Acid Supplementation ◽  
Rat Offspring

scholarly journals Analysis of Locus‐Specific DNA Methylation in Response to Chronic Folic Acid Supplementation and Withdrawal in Chinese Women

2008 ◽  
Vol 22 (S1) ◽  
Author(s):  
Jason O Brant ◽  
Jiang‐Hui Zhu ◽  
Krista Crider ◽  
R J Berry ◽  
Ling Hao ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Folic Acid ◽  
Chinese Women ◽  
Folic Acid Supplementation ◽  
Acid Supplementation

scholarly journals No Effect of Folic Acid Supplementation on Global DNA Methylation in Men and Women with Moderately Elevated Homocysteine

PLoS ONE ◽  
2011 ◽  
Vol 6 (9) ◽  
pp. e24976 ◽  
Author(s):  
Audrey Y. Jung ◽  
Yvo Smulders ◽  
Petra Verhoef ◽  
Frans J. Kok ◽  
Henk Blom ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Folic Acid ◽  
Folic Acid Supplementation ◽  
Global Dna Methylation ◽  
Men And Women ◽  
Acid Supplementation

Maternal Folic Acid Supplementation During Pregnancy Improves Neurobehavioral Development in Rat Offspring

2017 ◽  
Vol 55 (3) ◽  
pp. 2676-2684 ◽  
Author(s):  
Xinyan Wang ◽  
Wen Li ◽  
Shou Li ◽  
Jing Yan ◽  
John X. Wilson ◽  
...  
Keyword(s):  
Folic Acid ◽  
Folic Acid Supplementation ◽  
Acid Supplementation ◽  
Neurobehavioral Development ◽  
Rat Offspring

Folic acid supplementation dysregulates gene expression in lymphoblastoid cells – Implications in nutrition

2011 ◽  
Vol 412 (4) ◽  
pp. 688-692 ◽  
Author(s):  
Mohammed A. Junaid ◽  
Salomon Kuizon ◽  
Juan Cardona ◽  
Tayaba Azher ◽  
Noriko Murakami ◽  
...  
Keyword(s):  
Gene Expression ◽  
Folic Acid ◽  
Folic Acid Supplementation ◽  
Lymphoblastoid Cells ◽  
Acid Supplementation
Sign in / Sign up

Export Citation Format

Share Document